| Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1–AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the … TM Penning, ME Burczynski, JM Jez, CF Hung, HK Lin, H Ma, M Moore, ... Biochemical journal 351 (1), 67-77, 2000 | 806 | 2000 |
| Dihydrodiol Dehydrogenases and Polycyclic Aromatic Hydrocarbon Activation: Generation of Reactive and Redox Active o-Quinones TM Penning, ME Burczynski, CF Hung, KD McCoull, NT Palackal, ... Chemical research in toxicology 12 (1), 1-18, 1999 | 582 | 1999 |
| Activation of polycyclic aromatic hydrocarbontrans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human … NT Palackal, SH Lee, RG Harvey, IA Blair, TM Penning Journal of Biological Chemistry 277 (27), 24799-24808, 2002 | 272 | 2002 |
| Unusual microbial xylanases from insect guts YL Brennan, WN Callen, L Christoffersen, P Dupree, F Goubet, S Healey, ... Applied and Environmental Microbiology 70 (6), 3609-3617, 2004 | 225 | 2004 |
| The reactive oxygen species-and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the α, β-unsaturated aldehyde 4-hydroxy-2-nonenal to 1, 4-dihydroxy-2-nonene ME Burczynski, GR Sridhar, NT Palackal, TM Penning Journal of Biological Chemistry 276 (4), 2890-2897, 2001 | 218 | 2001 |
| An evolutionary route to xylanase process fitness N Palackal, Y Brennan, WN Callen, P Dupree, G Frey, F Goubet, ... Protein science 13 (2), 494-503, 2004 | 167 | 2004 |
| The Ubiquitous Aldehyde Reductase (AKR1A1) Oxidizes Proximate Carcinogen trans-Dihydrodiols to o-Quinones: Potential Role in Polycyclic Aromatic … NT Palackal, ME Burczynski, RG Harvey, TM Penning Biochemistry 40 (36), 10901-10910, 2001 | 152 | 2001 |
| Structure-function aspects and inhibitor design of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3) TM Penning, ME Burczynski, JM Jez, HK Lin, H Ma, M Moore, K Ratnam, ... Molecular and cellular endocrinology 171 (1-2), 137-149, 2001 | 133 | 2001 |
| A multifunctional hybrid glycosyl hydrolase discovered in an uncultured microbial consortium from ruminant gut N Palackal, CS Lyon, S Zaidi, P Luginbühl, P Dupree, F Goubet, ... Applied microbiology and biotechnology 74, 113-124, 2007 | 117 | 2007 |
| “High‐risk” host cell proteins (HCPs): A multi‐company collaborative view M Jones, N Palackal, F Wang, G Gaza‐Bulseco, K Hurkmans, Y Zhao, ... Biotechnology and bioengineering 118 (8), 2870-2885, 2021 | 116 | 2021 |
| Crystal Structure of Human Type III 3α-Hydroxysteroid Dehydrogenase/Bile Acid Binding Protein Complexed with NADP+ and Ursodeoxycholate, Y Jin, SE Stayrook, RH Albert, NT Palackal, TM Penning, M Lewis Biochemistry 40 (34), 10161-10168, 2001 | 109 | 2001 |
| 2019 white paper on recent issues in bioanalysis: FDA immunogenicity guidance, gene therapy, critical reagents, biomarkers and flow cytometry validation (Part 3–recommendations … S Piccoli, D Mehta, A Vitaliti, J Allinson, S Amur, S Eck, C Green, ... Bioanalysis 11 (24), 2207-2244, 2019 | 89 | 2019 |
| 2018 White Paper on Recent Issues in Bioanalysis: focus on flow cytometry, gene therapy, cut points and key clarifications on BAV (Part 3–LBA/cell-based assays: immunogenicity … L Stevenson, S Richards, R Pillutla, A Torri, J Kamerud, D Mehta, S Keller, ... Bioanalysis 10 (24), 1973-2001, 2018 | 56 | 2018 |
| Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1) NT Palackal, ME Burczynski, RG Harvey, TM Penning Chemico-biological interactions 130, 815-824, 2001 | 49 | 2001 |
| 2015 White Paper on recent issues in bioanalysis: focus on new technologies and biomarkers (Part 1–small molecules by LCMS) J Welink, E Fluhler, N Hughes, M Arnold, F Garofolo, M Bustard, ... Bioanalysis 7 (22), 2913-2925, 2015 | 46 | 2015 |
| 2014 White Paper on recent issues in bioanalysis: a full immersion in bioanalysis (Part 3–LBA and immunogenicity) L Stevenson, L Amaravadi, H Myler, L Salazar-Fontana, B Gorovits, ... Bioanalysis 6 (24), 3355-3368, 2014 | 46 | 2014 |
| 2017 White Paper on Recent Issues in Bioanalysis: Aren’t Bmv Guidance/Guidelines ‘Scientific’? (Part 1 – LCMS: Small Molecules, Peptides and Small Molecule … J Welink, E Yang, N Hughes, B Rago, E Woolf, J Sydor, L Coppola, ... Bioanalysis 9 (22), 1807-1825, 2017 | 41 | 2017 |
| 2020 White Paper on Recent Issues in Bioanalysis: BAV Guidance, CLSI H62, Biotherapeutics Stability, Parallelism Testing, CyTOF and Regulatory Feedback (Part 2A–Recommendations … S Spitz, Y Zhang, S Fischer, K McGuire, U Sommer, L Amaravadi, ... Bioanalysis 13 (5), 295-361, 2021 | 28 | 2021 |
| 2021 White Paper on Recent Issues in Bioanalysis: ISR for Biomarkers, Liquid Biopsies, Spectral Cytometry, Inhalation/Oral & Multispecific Biotherapeutics, Accuracy/LLOQ for … S Hersey, S Keller, J Mathews, L King, A Bandukwala, F Berisha, ... Bioanalysis 14 (10), 627-692, 2022 | 23 | 2022 |
| 2022 White Paper on Recent Issues in Bioanalysis: ICH M10 BMV Guideline & Global Harmonization; Hybrid Assays; Oligonucleotides & ADC; Non-Liquid & Rare Matrices; Regulatory … M Szapacs, W Jian, D Spellman, J Cunliffe, E Verburg, S Kaur, J Kellie, ... Bioanalysis 15 (16), 955-1016, 2023 | 13 | 2023 |
Trevor PenningUniversity of PennsylvaniaEmail confirmado em upenn.edu
