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Gerhard Multhaup
Gerhard Multhaup
Professor of Pharmacology
Email confirmado em mcgill.ca
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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
J Kang, HG Lemaire, A Unterbeck, JM Salbaum, CL Masters, ...
Nature 325 (6106), 733-736, 1987
63611987
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
CL Masters, G Simms, NA Weinman, G Multhaup, BL McDonald, ...
Proceedings of the National Academy of Sciences 82 (12), 4245-4249, 1985
59031985
Rapid induction of Alzheimer Aβ amyloid formation by zinc
AI Bush, WH Pettingell, G Multhaup, M d Paradis, JP Vonsattel, JF Gusella, ...
Science 265 (5177), 1464-1467, 1994
19791994
The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
X Huang, CS Atwood, MA Hartshorn, G Multhaup, LE Goldstein, ...
Biochemistry 38 (24), 7609-7616, 1999
14371999
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.
CL Masters, G Multhaup, G Simms, J Pottgiesser, RN Martins, ...
The EMBO journal 4 (11), 2757-2763, 1985
13481985
Cu (II) potentiation of Alzheimer Aβ neurotoxicity: correlation with cell-free hydrogen peroxide production and metal reduction
X Huang, MP Cuajungco, CS Atwood, MA Hartshorn, JDA Tyndall, ...
Journal of Biological Chemistry 274 (52), 37111-37116, 1999
10161999
The amyloid precursor protein of Alzheimer's disease in the reduction of copper (II) to copper (I)
G Multhaup, A Schlicksupp, L Hesse, D Beher, T Ruppert, CL Masters, ...
Science 271 (5254), 1406-1409, 1996
8471996
Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease
B Rumble, R Retallack, C Hilbich, G Simms, G Multhaup, R Martins, ...
New England Journal of Medicine 320 (22), 1446-1452, 1989
8401989
Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
M Sastre, H Steiner, K Fuchs, A Capell, G Multhaup, MM Condron, ...
EMBO reports, 2001
6762001
Copper in disorders with neurological symptoms: Alzheimer’s, Menkes, and Wilson diseases
D Strausak, JFB Mercer, HH Dieter, W Stremmel, G Multhaup
Brain research bulletin 55 (2), 175-185, 2001
6342001
Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.
BD Shivers, C Hilbich, G Multhaup, M Salbaum, K Beyreuther, ...
The EMBO journal 7 (5), 1365-1370, 1988
5411988
A modified β‐amyloid hypothesis: intraneuronal accumulation of the β‐amyloid peptide–the first step of a fatal cascade
O Wirths, G Multhaup, TA Bayer
Journal of neurochemistry 91 (3), 513-520, 2004
5312004
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.
T Dyrks, A Weidemann, G Multhaup, JM Salbaum, HG Lemaire, J Kang, ...
The EMBO journal 7 (4), 949-957, 1988
5201988
A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic …
L Davies, B Wolska, C Hilbich, G Multhaup, R Martins, G Simms, ...
Neurology 38 (11), 1688-1688, 1988
5091988
Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes.
B Boes, H Hengel, T Ruppert, G Multhaup, UH Koszinowski, PM Kloetzel
The Journal of experimental medicine 179 (3), 901-909, 1994
4511994
Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice
O Wirths, G Multhaup, C Czech, V Blanchard, S Moussaoui, G Tremp, ...
Neuroscience letters 306 (1-2), 116-120, 2001
4322001
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice
TA Bayer, S Schäfer, A Simons, A Kemmling, T Kamer, R Tepests, ...
Proceedings of the National Academy of Sciences 100 (24), 14187-14192, 2003
4292003
The LPS receptor (CD14) links innate immunity with Alzheimer's disease
K Fassbender, S Walter, S Kühl, R Landmann, K Ishii, T Bertsch, ...
The FASEB Journal 18 (1), 203-205, 2004
4232004
A novel zinc (II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease
AI Bush, G Multhaup, RD Moir, TG Williamson, DH Small, B Rumble, ...
Journal of Biological Chemistry 268 (22), 16109-16112, 1993
4231993
The major polypeptide of scrapie‐associated fibrils (SAF) has the same size, charge distribution and N‐terminal protein sequence as predicted for the normal brain protein (PrP).
J Hope, LJ Morton, CF Farquhar, G Multhaup, K Beyreuther, RH Kimberlin
The EMBO journal 5 (10), 2591-2597, 1986
4111986
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