| Applications of machine learning in drug discovery and development J Vamathevan, D Clark, P Czodrowski, I Dunham, E Ferran, G Lee, B Li, ... Nature reviews Drug discovery 18 (6), 463-477, 2019 | 2568 | 2019 |
| BoxPlotR: a web tool for generation of box plots M Spitzer, J Wildenhain, J Rappsilber, M Tyers Nature methods 11 (2), 121-122, 2014 | 837 | 2014 |
| Open Targets Platform: new developments and updates two years on D Carvalho-Silva, A Pierleoni, M Pignatelli, CK Ong, L Fumis, ... Nucleic acids research 47 (D1), D1056-D1065, 2019 | 462 | 2019 |
| Open Targets Platform: supporting systematic drug–target identification and prioritisation D Ochoa, A Hercules, M Carmona, D Suveges, A Gonzalez-Uriarte, ... Nucleic acids research 49 (D1), D1302-D1310, 2021 | 377 | 2021 |
| Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P L Peil, AL Starosta, J Lassak, GC Atkinson, K Virumäe, M Spitzer, ... Proceedings of the National Academy of Sciences 110 (38), 15265-15270, 2013 | 220 | 2013 |
| Combinatorial strategies for combating invasive fungal infections M Spitzer, N Robbins, GD Wright Virulence 8 (2), 169-185, 2017 | 214 | 2017 |
| Cross‐species discovery of syncretic drug combinations that potentiate the antifungal fluconazole M Spitzer, E Griffiths, KM Blakely, J Wildenhain, L Ejim, L Rossi, ... Molecular systems biology 7 (1), 499, 2011 | 196 | 2011 |
| Prediction of synergism from chemical-genetic interactions by machine learning J Wildenhain, M Spitzer, S Dolma, N Jarvik, R White, M Roy, E Griffiths, ... Cell Systems 1 (6), 383-395, 2015 | 134 | 2015 |
| An antifungal combination matrix identifies a rich pool of adjuvant molecules that enhance drug activity against diverse fungal pathogens N Robbins, M Spitzer, T Yu, RP Cerone, AK Averette, YS Bahn, J Heitman, ... Cell reports 13 (7), 1481-1492, 2015 | 81 | 2015 |
| ALDH2 mediates 5-nitrofuran activity in multiple species L Zhou, H Ishizaki, M Spitzer, KL Taylor, ND Temperley, SL Johnson, ... Chemistry & biology 19 (7), 883-892, 2012 | 55 | 2012 |
| Combined zebrafish-yeast chemical-genetic screens reveal gene–copper-nutrition interactions that modulate melanocyte pigmentation H Ishizaki, M Spitzer, J Wildenhain, C Anastasaki, Z Zeng, S Dolma, ... Disease models & mechanisms 3 (9-10), 639-651, 2010 | 52 | 2010 |
| Zebrafish MITF-low melanoma subtype models reveal transcriptional subclusters and MITF-independent residual disease J Travnickova, S Wojciechowska, A Khamseh, P Gautier, DV Brown, ... Cancer research 79 (22), 5769-5784, 2019 | 47 | 2019 |
| Discovery of ibomycin, a complex macrolactone that exerts antifungal activity by impeding endocytic trafficking and membrane function N Robbins, M Spitzer, W Wang, N Waglechner, DJ Patel, JS O’Brien, ... Cell chemical biology 23 (11), 1383-1394, 2016 | 47 | 2016 |
| Immune disease variants modulate gene expression in regulatory CD4+ T cells L Bossini-Castillo, DA Glinos, N Kunowska, G Golda, AA Lamikanra, ... Cell genomics 2 (4), 2022 | 34 | 2022 |
| A yeast chemical genetic screen identifies inhibitors of human telomerase LH Wong, A Unciti-Broceta, M Spitzer, R White, M Tyers, L Harrington Chemistry & biology 20 (3), 333-340, 2013 | 33 | 2013 |
| Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism J Wildenhain, M Spitzer, S Dolma, N Jarvik, R White, M Roy, E Griffiths, ... Scientific data 3 (1), 1-9, 2016 | 21 | 2016 |
| Immune disease variants modulate gene expression in regulatory CD4+ T cells and inform drug targets L Bossini-Castillo, DA Glinos, N Kunowska, G Golda, A Lamikanra, ... bioRxiv, 654632, 2019 | 11 | 2019 |
| Identification of RNA-associated peptides, iRAP, defines precise sites of protein-RNA interaction L Peil, S Waghmare, L Fischer, M Spitzer, D Tollervey, J Rappsilber BioRxiv, 456111, 2018 | 8 | 2018 |
| Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing E Castonguay, SA White, A Kagansky, DJ St-Cyr, AG Castillo, C Brugger, ... Molecular and cellular biology 35 (4), 662-674, 2015 | 7 | 2015 |
| An antifungal combination matrix identifies a rich pool of adjuvant molecules that enhance drug activity against diverse fungal pathogens. Cell Rep. 2015; 13 (7): 1481–92 N Robbins, M Spitzer, T Yu, RP Cerone, AK Averette, YS Bahn, J Heitman, ... | 5 | |
Mike TyersThe Hospital for Sick ChildrenEmail confirmado em sickkids.ca