| Is allostery an intrinsic property of all dynamic proteins? K Gunasekaran, B Ma, R Nussinov Proteins: Structure, Function, and Bioinformatics 57 (3), 433-443, 2004 | 1037 | 2004 |
| Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG K Gunasekaran, M Pentony, M Shen, L Garrett, C Forte, A Woodward, ... Journal of Biological Chemistry 285 (25), 19637-19646, 2010 | 422 | 2010 |
| Extended disordered proteins: targeting function with less scaffold K Gunasekaran, CJ Tsai, S Kumar, D Zanuy, R Nussinov Trends in biochemical sciences 28 (2), 81-85, 2003 | 413 | 2003 |
| Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects G Kannan, M Wittekind, W Yan, M Pentony US Patent 8,592,562, 2013 | 333 | 2013 |
| Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys MS Kariolis, RC Wells, JA Getz, W Kwan, CS Mahon, R Tong, DJ Kim, ... Science translational medicine 12 (545), eaay1359, 2020 | 273 | 2020 |
| A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair M Florio, K Gunasekaran, M Stolina, X Li, L Liu, B Tipton, ... Nature communications 7 (1), 11505, 2016 | 255 | 2016 |
| Beta-hairpins in proteins revisited: lessons for de novo design. K Gunasekaran, C Ramakrishnan, P Balaram Protein engineering 10 (10), 1131-1141, 1997 | 214 | 1997 |
| Analysis of ordered and disordered protein complexes reveals structural features discriminating between stable and unstable monomers K Gunasekaran, CJ Tsai, R Nussinov Journal of molecular biology 341 (5), 1327-1341, 2004 | 197 | 2004 |
| Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice JC Ullman, A Arguello, JA Getz, A Bhalla, CS Mahon, J Wang, T Giese, ... Science Translational Medicine 12 (545), eaay1163, 2020 | 176 | 2020 |
| How different are structurally flexible and rigid binding sites? Sequence and structural features discriminating proteins that do and do not undergo conformational change upon … K Gunasekaran, R Nussinov Journal of molecular biology 365 (1), 257-273, 2007 | 175 | 2007 |
| Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic T Logan, MJ Simon, A Rana, GM Cherf, A Srivastava, SS Davis, RLY Low, ... Cell 184 (18), 4651-4668. e25, 2021 | 161 | 2021 |
| Stereochemical punctuation marks in protein structures: glycine and proline containing helix stop signals K Gunasekaran, HA Nagarajaram, C Ramakrishnan, P Balaram Journal of molecular biology 275 (5), 917-932, 1998 | 155 | 1998 |
| Disallowed Ramachandran conformations of amino acid residues in protein structures K Gunasekaran, C Ramakrishnan, P Balaram Journal of molecular biology 264 (1), 191-198, 1996 | 154 | 1996 |
| Protein–protein interactions: organization, cooperativity and mapping in a bottom-up Systems Biology approach O Keskin, B Ma, K Rogale, K Gunasekaran, R Nussinov Physical biology 2 (2), S24, 2005 | 140 | 2005 |
| Keeping it in the family: folding studies of related proteins K Gunasekaran, SJ Eyles, AT Hagler, LM Gierasch Current opinion in structural biology 11 (1), 83-93, 2001 | 135 | 2001 |
| Energy landscape of amyloidogenic peptide oligomerization by parallel-tempering molecular dynamics simulation: significant role of Asn ladder HH Tsai, M Reches, CJ Tsai, K Gunasekaran, E Gazit, R Nussinov Proceedings of the National Academy of Sciences 102 (23), 8174-8179, 2005 | 128 | 2005 |
| Conformational interconversions in peptide β-turns: analysis of turns in proteins and computational estimates of barriers K Gunasekaran, L Gomathi, C Ramakrishnan, J Chandrasekhar, ... Journal of molecular biology 284 (5), 1505-1516, 1998 | 108 | 1998 |
| Heterodimeric immunoglobulins G Kannan, M Florio, Z Liu, W Yan US Patent 10,233,237, 2019 | 101* | 2019 |
| A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism Z Liu, EC Leng, K Gunasekaran, M Pentony, M Shen, M Howard, J Stoops, ... Journal of Biological Chemistry 290 (12), 7535-7562, 2015 | 92 | 2015 |
| Host cell for making antibody fc-heterodimeric molecules using electrostatic steering effects G Kannan, M Wittekind, W Yan, MJ Pentony US Patent App. 14/037,040, 2014 | 84 | 2014 |
