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Wynand Smythe
Wynand Smythe
Associate Director - Pharmacometrics (Certara, Cape Town)
Email confirmado em certara.com - Página inicial
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PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking
A Vaid, R Ranjan, WA Smythe, HC Hoppe, P Sharma
Blood, The Journal of the American Society of Hematology 115 (12), 2500-2507, 2010
1702010
Comparison of dual therapies for lowering blood pressure in black Africans
DB Ojji, B Mayosi, V Francis, M Badri, V Cornelius, W Smythe, N Kramer, ...
New England Journal of Medicine 380 (25), 2429-2439, 2019
1512019
A semimechanistic pharmacokinetic-enzyme turnover model for rifampin autoinduction in adult tuberculosis patients
W Smythe, A Khandelwal, C Merle, R Rustomjee, M Gninafon, M Bocar Lo, ...
Antimicrobial agents and chemotherapy 56 (4), 2091-2098, 2012
1172012
Actin is required for endocytic trafficking in the malaria parasite Plasmodium falciparum
WA Smythe, KA Joiner, HC Hoppe
Cellular microbiology 10 (2), 452-464, 2008
852008
Bioavailability of two licensed paediatric rifampicin suspensions: implications for quality control programmes
H McIlleron, H Hundt, W Smythe, A Bekker, J Winckler, L Van der Laan, ...
The International Journal of Tuberculosis and Lung Disease 20 (7), 915-919, 2016
292016
Gatifloxacin pharmacokinetics/pharmacodynamics–based optimal dosing for pulmonary and meningeal multidrug-resistant tuberculosis
D Deshpande, JG Pasipanodya, S Srivastava, P Bendet, T Koeuth, ...
Clinical Infectious Diseases 67 (suppl_3), S274-S283, 2018
262018
Evaluation of initial and steady-state gatifloxacin pharmacokinetics and dose in pulmonary tuberculosis patients by using Monte Carlo simulations
W Smythe, CS Merle, R Rustomjee, M Gninafon, MB Lo, O Bah-Sow, ...
Antimicrobial agents and chemotherapy 57 (9), 4164-4171, 2013
232013
Bocar Lo M, Sow OB, Olliaro PL, Lienhardt C, Horton J, Smith P, McIlleron H, Simonsson USH. 2012. A semimechanistic pharmacokinetic-enzyme turnover model for rifampin …
W Smythe, A Khandelwal, C Merle, R Rustomjee, M Gninafon
Antimicrob Agents Chemother 56 (4), 2091-2098, 0
22
Pharmacokinetic profile and safety of adjusted doses of darunavir/ritonavir with rifampicin in people living with HIV
I Ebrahim, G Maartens, L Wiesner, C Orrell, W Smythe, H McIlleron
Journal of Antimicrobial Chemotherapy 75 (4), 1019-1025, 2020
202020
Quality assurance of rifampicin-containing fixed-drug combinations in South Africa: dosing implications
MT Chirehwa, L Wiesner, B Wright, W Smythe, N Kramer, H McIlleron
The International Journal of Tuberculosis and Lung Disease 22 (5), 537-543, 2018
182018
Artificial intelligence–derived 3-way concentration-dependent antagonism of gatifloxacin, pyrazinamide, and rifampicin during treatment of pulmonary tuberculosis
JG Pasipanodya, W Smythe, CS Merle, PL Olliaro, D Deshpande, ...
Clinical Infectious Diseases 67 (suppl_3), S284-S292, 2018
142018
A population pharmacokinetic model for rifampicin auto-induction
P Denti, W Smythe, USH Simonsson, R Rustomjee, P Onyebujoh, P Smith, ...
3rd International Workshop on Clinical Pharmacology of TB Drugs, 2010
132010
Rationale and design of the comparison of 3 combination therapies in lowering blood pressure in black Africans (CREOLE study): 2× 3 factorial randomized single-blind …
DB Ojji, N Poulter, A Damasceno, K Sliwa, W Smythe, N Kramer, M Badri, ...
American Heart Journal 202, 5-12, 2018
122018
A differential response to antihypertensive therapy in African men and women: insights from the CREOLE trial
DB Ojji, GL Shedul, M Sani, OS Ogah, A Dzudie, F Barasa, C Mondo, ...
American Journal of Hypertension 35 (6), 551-560, 2022
62022
Characterizing population pharmacokinetic/pharmacodynamic relationships in pulmonary tuberculosis infected adults using nonlinear mixed effects modelling
WA Smythe
52016
Effect of 3, 2-drug combinations of antihypertensive therapies on blood pressure variability in black African patients: secondary analyses of the CREOLE Trial
DB Ojji, V Cornelius, G Partington, V Francis, S Pandie, W Smythe, ...
Hypertension 79 (11), 2593-2600, 2022
42022
Investigational Medicinal Product (IMP) Management
W Smythe, N Kramer
A Comprehensive and Practical Guide to Clinical Trials, 103-117, 2017
12017
Gatifloxacin pharmacokinetics/pharmacodynamics-based optimal dosing for pulmonary and meningeal multidrug-resistant tuberculosis.
DD Devyani Deshpande, JG Pasipanodya, SS Shashikant Srivastava, ...
2018
Bioavailability of two licensed paediatric rifampicin suspensions: implications for quality control programmes
AC Hesseling, HJ Zar, H Hundt, H McIlleron, A van Rie, L Wiesner, ...
International Union Against Tuberculosis and Lung Disease, 2016
2016
PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking.
AV Ankush Vaid, RR Ravikant Ranjan, WA Smythe, HC Hoppe, ...
2010
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