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Will McLean, Ph.D.
Will McLean, Ph.D.
Harvard Medical School, MIT, Frequency Therapeutics, Skylark Bio
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Clonal expansion of Lgr5-positive cells from mammalian cochlea and high-purity generation of sensory hair cells
WJ McLean, X Yin, L Lu, DR Lenz, D McLean, R Langer, JM Karp, ...
Cell reports 18 (8), 1917-1929, 2017
2102017
Distribution of the Na, K-ATPase α subunit in the rat spiral ganglion and organ of corti
WJ McLean, KA Smith, E Glowatzki, SJ Pyott
Journal of the Association for Research in Otolaryngology 10, 37-49, 2009
1242009
BK channels mediate cholinergic inhibition of high frequency cochlear hair cells
E Wersinger, WJ McLean, PA Fuchs, SJ Pyott
Plos one 5 (11), e13836, 2010
852010
Distinct capacity for differentiation to inner ear cell types by progenitor cells of the cochlea and vestibular organs
WJ McLean, DT McLean, RA Eatock, ASB Edge
Development 143 (23), 4381-4393, 2016
562016
Improved speech intelligibility in subjects with stable sensorineural hearing loss following intratympanic dosing of FX-322 in a phase 1b study
WJ McLean, AS Hinton, JTJ Herby, AN Salt, JJ Hartsock, S Wilson, ...
Otology & Neurotology 42 (7), e849-e857, 2021
452021
Distribution of Na, K-ATPase α subunits in rat vestibular sensory epithelia
O Schuth, WJ McLean, RA Eatock, SJ Pyott
Journal of the Association for Research in Otolaryngology 15, 739-754, 2014
252014
Approaches to treat sensorineural hearing loss by hair-cell regeneration: The current state of therapeutic developments and their potential impact on audiological clinical practice
AS Hinton, A Yang-Hood, AD Schrader, C Loose, KK Ohlemiller, ...
Journal of the American Academy of Audiology 32 (10), 661-669, 2021
102021
Methods for controlled proliferation of stem cells/generating inner ear hair cells using gsk-3-alpha inhibitors
C Loose, W Mclean, M Harrison
US Patent App. 16/080,813, 2019
72019
Thermoreversible compositions for administration of therapeutic agents
C Loose, W Mclean, M Harrison, MR Jirousek
US Patent 10,213,511, 2019
72019
1, 5-dihydro-2H-pyrrol-2-one compounds and methods of using same
C Loose, B Tait, R Manchanda, W Mclean
US Patent 10,383,881, 2019
62019
Solubilized compositions for controlled proliferation of stem cells/generating inner ear hair cells using GSK3 inhibitors: III
C Loose, W Mclean, M Harrison, MR Jirousek
US Patent 10,016,507, 2018
62018
Automated western blot analysis of ototoxin-induced prestin burst in the blood after cyclodextrin exposure
MS Harrison, BG Driscoll, J Farnsworth, A Hinton, M Peppi, W McLean, ...
Otology & Neurotology 44 (9), e653-e659, 2023
52023
Methods for controlled proliferation of vestibular stem cells/generating inner ear hair cells using wnt and tgfbeta-inhibition
W Mclean
US Patent App. 16/080,820, 2019
52019
Solubilized compositions for controlled proliferation of stem cells/generating inner ear hair cells using GSK3 inhibitors: I
C Loose, W Mclean, M Harrison, MR Jirousek
US Patent 10,201,540, 2019
42019
Solubilized compositions for controlled proliferation of stem cells/generating inner ear hair cells using a GSK3 inhibitor: I
C Loose, W Mclean, M Harrison, MR Jirousek
US Patent 11,033,546, 2021
32021
Methods for controlled proliferation of stem cells/generating inner ear hair cells using 3-(pyridin-2-yl)-1H-indol-2-ol based compounds
C Loose, W Mclean, HD Melissa
US Patent 10,220,041, 2019
32019
Methods for controlled proliferation of stem cells/generating inner ear hair cells using 3-(pyridin-2-yl)-1H-indol-2-ol based compounds
C Loose, W Mclean, HD Melissa
US Patent 9,968,615, 2018
32018
Methods for controlled proliferation of stem cells/generating inner ear hair cells using 1, 2, 3, 4-tetrahydro-[1, 4] diazepino [6, 7, 1-hi] indolyl based compounds
C Loose, W Mclean, HD Melissa
US Patent 9,913,848, 2018
32018
Toward a true cure for hearing impairment
W McLean
Science 359 (6380), 1113-1113, 2018
32018
Solubilized compositions for controlled proliferation of stem cells/generating inner ear hair cells using a GSK3 inhibitor: IV
C Loose, W Mclean, M Harrison, MR Jirousek
US Patent 11,260,130, 2022
22022
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