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Ton N.M. Schumacher
Ton N.M. Schumacher
The Netherlands Cancer Institute, Third Rock Ventures
Email confirmado em nki.nl - Página inicial
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Signatures of mutational processes in human cancer
LB Alexandrov, S Nik-Zainal, DC Wedge, SAJR Aparicio, S Behjati, ...
nature 500 (7463), 415-421, 2013
105882013
Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer
NA Rizvi, MD Hellmann, A Snyder, P Kvistborg, V Makarov, JJ Havel, ...
Science 348 (6230), 124-128, 2015
85442015
Neoantigens in cancer immunotherapy
TN Schumacher, RD Schreiber
Science 348 (6230), 69-74, 2015
51882015
Mutations associated with acquired resistance to PD-1 blockade in melanoma
JM Zaretsky, A Garcia-Diaz, DS Shin, H Escuin-Ordinas, W Hugo, ...
New England Journal of Medicine 375 (9), 819-829, 2016
32002016
The human cell atlas
A Regev, SA Teichmann, ES Lander, I Amit, C Benoist, E Birney, ...
elife 6, e27041, 2017
23212017
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
MM Gubin, X Zhang, H Schuster, E Caron, JP Ward, T Noguchi, Y Ivanova, ...
Nature 515 (7528), 577-581, 2014
22362014
B cells and tertiary lymphoid structures promote immunotherapy response
BA Helmink, SM Reddy, J Gao, S Zhang, R Basar, R Thakur, K Yizhak, ...
Nature 577 (7791), 549-555, 2020
21102020
Regulation and function of the PD-L1 checkpoint
C Sun, R Mezzadra, TN Schumacher
Immunity 48 (3), 434-452, 2018
20872018
Guidelines for the use of flow cytometry and cell sorting in immunological studies
A Cossarizza, HD Chang, A Radbruch, A Acs, D Adam, S Adam‐Klages, ...
European journal of immunology 49 (10), 1457-1973, 2019
19942019
Defining ‘T cell exhaustion’
CU Blank, WN Haining, W Held, PG Hogan, A Kallies, E Lugli, RC Lynn, ...
Nature Reviews Immunology 19 (11), 665-674, 2019
13422019
Synergism of cytotoxic T lymphocyte–associated antigen 4 blockade and depletion of CD25+ regulatory T cells in antitumor therapy reveals alternative pathways for suppression of …
RPM Sutmuller, LM van Duivenvoorde, A van Elsas, TNM Schumacher, ...
Journal of Experimental Medicine 194 (6), 823-832, 2001
13192001
CD8+ T cell states in human cancer: insights from single-cell analysis
AM Van der Leun, DS Thommen, TN Schumacher
Nature Reviews Cancer 20 (4), 218-232, 2020
11922020
Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers
M Chalabi, LF Fanchi, KK Dijkstra, JG Van den Berg, AG Aalbers, ...
Nature medicine 26 (4), 566-576, 2020
11912020
Empty MHC class I molecules come out in the cold
HG Ljunggren, NJ Stam, C Öhlén, JJ Neefjes, P Höglund, MT Heemels, ...
Nature 346 (6283), 476-480, 1990
11471990
T cell dysfunction in cancer
DS Thommen, TN Schumacher
Cancer cell 33 (4), 547-562, 2018
11432018
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade
DS Thommen, VH Koelzer, P Herzig, A Roller, M Trefny, S Dimeloe, ...
Nature medicine 24 (7), 994-1004, 2018
10462018
Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma
N van Rooij, MM van Buuren, D Philips, A Velds, M Toebes, B Heemskerk, ...
Journal of Clinical Oncology 31 (32), e439-e442, 2013
9882013
Dysfunctional CD8 T cells form a proliferative, dynamically regulated compartment within human melanoma
H Li, AM van der Leun, I Yofe, Y Lubling, D Gelbard-Solodkin, ...
Cell 176 (4), 775-789. e18, 2019
9752019
Generation of tumor-reactive T cells by co-culture of peripheral blood lymphocytes and tumor organoids
KK Dijkstra, CM Cattaneo, F Weeber, M Chalabi, J van de Haar, ...
Cell 174 (6), 1586-1598. e12, 2018
9652018
CD27 is required for generation and long-term maintenance of T cell immunity
J Hendriks, LA Gravestein, K Tesselaar, RAW Van Lier, TNM Schumacher, ...
Nature immunology 1 (5), 433-440, 2000
9532000
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Artigos 1–20