| Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer D Öhlund, A Handly-Santana, G Biffi, E Elyada, AS Almeida, ... Journal of Experimental Medicine 214 (3), 579-596, 2017 | 2250 | 2017 |
| Organoid models of human and mouse ductal pancreatic cancer SF Boj, CI Hwang, LA Baker, IIC Chio, DD Engle, V Corbo, M Jager, ... Cell 160 (1), 324-338, 2015 | 2146 | 2015 |
| Transcriptional regulation by Nrf2 C Tonelli, IIC Chio, DA Tuveson Antioxidants & redox signaling 29 (17), 1727-1745, 2018 | 2005 | 2018 |
| Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH J Yun, E Mullarky, C Lu, KN Bosch, A Kavalier, K Rivera, J Roper, IIC Chio, ... Science 350 (6266), 1391-1396, 2015 | 970 | 2015 |
| ROS in cancer: the burning question IIC Chio, DA Tuveson Trends in molecular medicine 23 (5), 411-429, 2017 | 554 | 2017 |
| NRF2 promotes tumor maintenance by modulating mRNA translation in pancreatic cancer IIC Chio, SM Jafarnejad, M Ponz-Sarvise, Y Park, K Rivera, W Palm, ... Cell 166 (4), 963-976, 2016 | 379 | 2016 |
| D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function M Sasaki, CB Knobbe, M Itsumi, AJ Elia, IS Harris, IIC Chio, RA Cairns, ... Genes & development 26 (18), 2038-2049, 2012 | 365 | 2012 |
| Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development T Ueda, M Sasaki, AJ Elia, IIC Chio, K Hamada, R Fukunaga, TW Mak Proceedings of the National Academy of Sciences 107 (32), 13984-13990, 2010 | 239 | 2010 |
| A predictive model for selective targeting of the Warburg effect through GAPDH inhibition with a natural product MV Liberti, Z Dai, SE Wardell, JA Baccile, X Liu, X Gao, R Baldi, ... Cell metabolism 26 (4), 648-659. e8, 2017 | 213 | 2017 |
| Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15 S Inoue, Z Hao, AJ Elia, D Cescon, L Zhou, J Silvester, B Snow, IS Harris, ... Genes & development 27 (10), 1101-1114, 2013 | 157 | 2013 |
| Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors NJ Chen, IIC Chio, WJ Lin, G Duncan, H Chau, D Katz, HL Huang, ... Proceedings of the National Academy of Sciences 105 (34), 12429-12434, 2008 | 140 | 2008 |
| Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP+/NADPH ratio M Itsumi, S Inoue, AJ Elia, K Murakami, M Sasaki, EF Lind, D Brenner, ... Cell Death & Differentiation 22 (11), 1837-1845, 2015 | 119 | 2015 |
| eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma K Chan, F Robert, C Oertlin, D Kapeller-Libermann, D Avizonis, ... Nature communications 10 (1), 5151, 2019 | 108 | 2019 |
| Bioactivation of napabucasin triggers reactive oxygen species–mediated cancer cell death FEM Froeling, MM Swamynathan, A Deschênes, IIC Chio, E Brosnan, ... Clinical Cancer Research 25 (23), 7162-7174, 2019 | 72 | 2019 |
| Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model T Berger, T Ueda, E Arpaia, IIC Chio, EA Shirdel, I Jurisica, K Hamada, ... Oncogene 32 (41), 4989-4994, 2013 | 71 | 2013 |
| p53 mutations change phosphatidylinositol acyl chain composition A Naguib, G Bencze, DD Engle, IIC Chio, T Herzka, K Watrud, S Bencze, ... Cell reports 10 (1), 8-19, 2015 | 65 | 2015 |
| Identification of resistance pathways specific to malignancy using organoid models of pancreatic cancer M Ponz-Sarvise, V Corbo, H Tiriac, DD Engle, KK Frese, TE Oni, ... Clinical Cancer Research 25 (22), 6742-6755, 2019 | 62 | 2019 |
| Metastasis in pancreatic ductal adenocarcinoma: current standing and methodologies M Ayres Pereira, IIC Chio Genes 11 (1), 6, 2019 | 61 | 2019 |
| Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFκB2 signaling that contributes to autoimmunity WJ Lin, YW Su, YC Lu, Z Hao, IIC Chio, NJ Chen, A Brüstle, WY Li, ... Proceedings of the National Academy of Sciences 108 (45), 18354-18359, 2011 | 53 | 2011 |
| Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis D He, H Feng, B Sundberg, J Yang, J Powers, AH Christian, JE Wilkinson, ... Molecular cell 82 (16), 3045-3060. e11, 2022 | 52 | 2022 |