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David W Holden
David W Holden
Regius Professor of Infectious Disease, Imperial College London
Email confirmado em imperial.ac.uk - Página inicial
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Simultaneous identification of bacterial virulence genes by negative selection
M Hensel, JE Shea, C Gleeson, MD Jones, E Dalton, DW Holden
Science 269 (5222), 400-403, 1995
16021995
Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium.
JE Shea, M Hensel, C Gleeson, DW Holden
Proceedings of the National Academy of Sciences 93 (6), 2593-2597, 1996
10581996
Internalization of Salmonella by macrophages induces formation of nonreplicating persisters
S Helaine, AM Cheverton, KG Watson, LM Faure, SA Matthews, ...
Science 343 (6167), 204-208, 2014
8162014
Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation …
M Hensel, JE Shea, SR Waterman, R Mundy, T Nikolaus, G Banks, ...
Molecular microbiology 30 (1), 163-174, 1998
7761998
Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase
A Vazquez-Torres, Y Xu, J Jones-Carson, DW Holden, SM Lucia, ...
Science 287 (5458), 1655-1658, 2000
7342000
Salmonella maintains the integrity of its intracellular vacuole through the action of SifA
CR Beuzón, S Méresse, KE Unsworth, J Ruíz‐Albert, S Garvis, ...
The EMBO journal, 2000
7282000
A pneumococcal pilus influences virulence and host inflammatory responses
MA Barocchi, J Ries, X Zogaj, C Hemsley, B Albiger, A Kanth, S Dahlberg, ...
Proceedings of the National Academy of Sciences 103 (8), 2857-2862, 2006
6212006
Identification of Staphylococcus aureus virulence genes in a murine model of bacteraemia using signature‐tagged mutagenesis
JM Mei, F Nourbakhsh, CW Ford, DW Holden
Molecular microbiology 26 (2), 399-407, 1997
5671997
Functions and effectors of the Salmonella pathogenicity island 2 type III secretion system
SR Waterman, DW Holden
Cellular microbiology 5 (8), 501-511, 2003
5262003
The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice
JS Brown, T Hussell, SM Gilliland, DW Holden, JC Paton, MR Ehrenstein, ...
Proceedings of the National Academy of Sciences 99 (26), 16969-16974, 2002
5072002
Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors
R Figueira, DW Holden
Microbiology 158 (5), 1147-1161, 2012
4702012
Salmonella SPI-2 type III secretion system effectors: molecular mechanisms and physiological consequences
E Jennings, TLM Thurston, DW Holden
Cell host & microbe 22 (2), 217-231, 2017
4122017
Dynamics of intracellular bacterial replication at the single cell level
S Helaine, JA Thompson, KG Watson, M Liu, C Boyle, DW Holden
Proceedings of the National Academy of Sciences 107 (8), 3746-3751, 2010
3592010
A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence
JS Brown, SM Gilliland, DW Holden
Molecular microbiology 40 (3), 572-585, 2001
3582001
A functional genomic analysis of type 3 Streptococcus pneumoniae virulence
GW Lau, S Haataja, M Lonetto, SE Kensit, A Marra, AP Bryant, D McDevitt, ...
Molecular microbiology 40 (3), 555-571, 2001
3422001
Gene transfer system for the phytopathogenic fungus Ustilago maydis.
JUN Wang, DW Holden, SA Leong
Proceedings of the National Academy of Sciences 85 (3), 865-869, 1988
3371988
Complementary activities of SseJ and SifA regulate dynamics of the Salmonella typhimurium vacuolar membrane
J Ruiz‐Albert, XJ Yu, CR Beuzón, AN Blakey, EE Galyov, DW Holden
Molecular microbiology 44 (3), 645-661, 2002
3252002
Intracellular replication of Salmonella typhimurium strains in specific subsets of splenic macrophages in vivo
SP Salcedo, M Noursadeghi, J Cohen, DW Holden
Cellular microbiology 3 (9), 587-597, 2001
3192001
SseL, a Salmonella deubiquitinase required for macrophage killing and virulence
A Rytkönen, J Poh, J Garmendia, C Boyle, A Thompson, M Liu, ...
Proceedings of the National Academy of Sciences 104 (9), 3502-3507, 2007
2872007
In vivo genetic analysis of bacterial virulence
SL Chiang, JJ Mekalanos, DW Holden
Annual Reviews in Microbiology 53 (1), 129-154, 1999
2811999
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Artigos 1–20