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David R. Liu
David R. Liu
E-mail confirmado em fas.harvard.edu - Página inicial
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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
M Tahiliani, KP Koh, Y Shen, WA Pastor, H Bandukwala, Y Brudno, ...
Science 324 (5929), 930-935, 2009
66042009
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
AC Komor, YB Kim, MS Packer, JA Zuris, DR Liu
Nature 533 (7603), 420-424, 2016
53092016
Programmable base editing of A• T to G• C in genomic DNA without DNA cleavage
NM Gaudelli, AC Komor, HA Rees, MS Packer, AH Badran, DI Bryson, ...
Nature 551 (7681), 464-471, 2017
39562017
Search-and-replace genome editing without double-strand breaks or donor DNA
AV Anzalone, PB Randolph, JR Davis, AA Sousa, LW Koblan, JM Levy, ...
Nature 576 (7785), 149-157, 2019
39512019
Scaling of theory‐of‐mind tasks
HM Wellman, D Liu
Child development 75 (2), 523-541, 2004
29652004
Oncogenic signaling pathways in the cancer genome atlas
F Sanchez-Vega, M Mina, J Armenia, WK Chatila, A Luna, KC La, ...
Cell 173 (2), 321-337. e10, 2018
27272018
DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists
DW Huang, BT Sherman, Q Tan, J Kir, D Liu, D Bryant, Y Guo, ...
Nucleic acids research 35 (suppl_2), W169-W175, 2007
22912007
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
V Pattanayak, S Lin, JP Guilinger, E Ma, JA Doudna, DR Liu
Nature biotechnology 31 (9), 839-843, 2013
19312013
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
AV Anzalone, LW Koblan, DR Liu
Nature biotechnology 38 (7), 824-844, 2020
18332020
Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
JH Hu, SM Miller, MH Geurts, W Tang, L Chen, N Sun, CM Zeina, X Gao, ...
Nature 556 (7699), 57-63, 2018
16552018
Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a …
ED Kwon, CG Drake, HI Scher, K Fizazi, A Bossi, AJM Van den Eertwegh, ...
The lancet oncology 15 (7), 700-712, 2014
16232014
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
JA Zuris, DB Thompson, Y Shu, JP Guilinger, JL Bessen, JH Hu, ...
Nature biotechnology 33 (1), 73-80, 2015
16032015
Base editing: precision chemistry on the genome and transcriptome of living cells
HA Rees, DR Liu
Nature reviews genetics 19 (12), 770-788, 2018
15942018
CRISPR-based technologies for the manipulation of eukaryotic genomes
AC Komor, AH Badran, DR Liu
Cell 168 (1), 20-36, 2017
12962017
Sequence-controlled polymers
JF Lutz, M Ouchi, DR Liu, M Sawamoto
Science 341 (6146), 1238149, 2013
12872013
Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
JP Guilinger, DB Thompson, DR Liu
Nature biotechnology 32 (6), 577-582, 2014
12052014
CRISPResso2 provides accurate and rapid genome editing sequence analysis
K Clement, H Rees, MC Canver, JM Gehrke, R Farouni, JY Hsu, MA Cole, ...
Nature biotechnology 37 (3), 224-226, 2019
11762019
A cancer cell program promotes T cell exclusion and resistance to checkpoint blockade
L Jerby-Arnon, P Shah, MS Cuoco, C Rodman, MJ Su, JC Melms, ...
Cell 175 (4), 984-997. e24, 2018
11352018
Methods for the directed evolution of proteins
MS Packer, DR Liu
Nature Reviews Genetics 16 (7), 379-394, 2015
11082015
A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog
JK Ichida, J Blanchard, K Lam, EY Son, JE Chung, D Egli, KM Loh, ...
Cell stem cell 5 (5), 491-503, 2009
9762009
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