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Madhusudhanan sukumar
Madhusudhanan sukumar
Janssen Pharmaceuticals
E-mail confirmado em ITS.JNJ.com - Página inicial
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Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
M Sukumar, J Liu, Y Ji, M Subramanian, JG Crompton, Z Yu, ...
The Journal of clinical investigation 123 (10), 4479-4488, 2013
9602013
Identification of essential genes for cancer immunotherapy
SJ Patel, NE Sanjana, RJ Kishton, A Eidizadeh, SK Vodnala, M Cam, ...
Nature 548 (7669), 537-542, 2017
8592017
Ionic immune suppression within the tumour microenvironment limits T cell effector function
R Eil, SK Vodnala, D Clever, CA Klebanoff, M Sukumar, JH Pan, ...
Nature 537 (7621), 539-543, 2016
5962016
Th17 cells are long lived and retain a stem cell-like molecular signature
P Muranski, ZA Borman, SP Kerkar, CA Klebanoff, Y Ji, L Sanchez-Perez, ...
Immunity 35 (6), 972-985, 2011
5122011
Metabolic regulation of T cell longevity and function in tumor immunotherapy
RJ Kishton, M Sukumar, NP Restifo
Cell metabolism 26 (1), 94-109, 2017
4812017
T cell stemness and dysfunction in tumors are triggered by a common mechanism
SK Vodnala, R Eil, RJ Kishton, M Sukumar, TN Yamamoto, NH Ha, ...
Science 363 (6434), eaau0135, 2019
4602019
Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy
M Sukumar, J Liu, GU Mehta, SJ Patel, R Roychoudhuri, JG Crompton, ...
Cell metabolism 23 (1), 63-76, 2016
3732016
Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics
JG Crompton, M Sukumar, R Roychoudhuri, D Clever, A Gros, RL Eil, ...
Cancer research 75 (2), 296-305, 2015
3652015
BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers
R Roychoudhuri, D Clever, P Li, Y Wakabayashi, KM Quinn, CA Klebanoff, ...
Nature immunology 17 (7), 851-860, 2016
2992016
Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy
CA Klebanoff, CD Scott, AJ Leonardi, TN Yamamoto, AC Cruz, C Ouyang, ...
The Journal of clinical investigation 126 (1), 318-334, 2016
2562016
Oxygen sensing by T cells establishes an immunologically tolerant metastatic niche
D Clever, R Roychoudhuri, MG Constantinides, MH Askenase, ...
Cell 166 (5), 1117-1131. e14, 2016
2492016
Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells
Y Ji, Z Pos, M Rao, CA Klebanoff, Z Yu, M Sukumar, RN Reger, ...
Nature immunology 12 (12), 1230-1237, 2011
2472011
Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy
CA Klebanoff, JG Crompton, AJ Leonardi, TN Yamamoto, SS Chandran, ...
JCI insight 2 (23), 2017
2032017
Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance
DC Palmer, GC Guittard, Z Franco, JG Crompton, RL Eil, SJ Patel, Y Ji, ...
Journal of Experimental Medicine 212 (12), 2095-2113, 2015
2002015
Retinoic acid controls the homeostasis of pre-cDC–derived splenic and intestinal dendritic cells
CA Klebanoff, SP Spencer, P Torabi-Parizi, JR Grainger, R Roychoudhuri, ...
Journal of Experimental Medicine 210 (10), 1961-1976, 2013
1642013
Uncoupling T‐cell expansion from effector differentiation in cell‐based immunotherapy
JG Crompton, M Sukumar, NP Restifo
Immunological reviews 257 (1), 264-276, 2014
1522014
Multi-phenotype CRISPR-Cas9 screen identifies p38 kinase as a target for adoptive immunotherapies
D Gurusamy, AN Henning, TN Yamamoto, Z Yu, N Zacharakis, S Krishna, ...
Cancer cell 37 (6), 818-833. e9, 2020
1382020
Lineage relationship of CD8+ T cell subsets is revealed by progressive changes in the epigenetic landscape
JG Crompton, M Narayanan, S Cuddapah, R Roychoudhuri, Y Ji, W Yang, ...
Cellular & molecular immunology 13 (4), 502-513, 2016
1312016
Nutrient competition: a new axis of tumor immunosuppression
M Sukumar, R Roychoudhuri, NP Restifo
Cell 162 (6), 1206-1208, 2015
1272015
miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines
Y Ji, C Wrzesinski, Z Yu, J Hu, S Gautam, NV Hawk, WG Telford, ...
Proceedings of the National Academy of Sciences 112 (2), 476-481, 2015
1082015
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