Artigos com autorizações de acesso público - Joseph LeharSaiba mais
13 artigos disponíveis publicamente
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
J Barretina, G Caponigro, N Stransky, K Venkatesan, AA Margolin, S Kim, ...
Nature 483 (7391), 603-607, 2012
Autorizações: US National Institutes of Health
Next-generation characterization of the cancer cell line encyclopedia
M Ghandi, FW Huang, J Jané-Valbuena, GV Kryukov, CC Lo, ...
Nature 569 (7757), 503-508, 2019
Autorizações: US National Institutes of Health
Synergistic drug combinations tend to improve therapeutically relevant selectivity
J Lehár, AS Krueger, W Avery, AM Heilbut, LM Johansen, ER Price, ...
Nature biotechnology 27 (7), 659-666, 2009
Autorizações: US National Institutes of Health
CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors
SR Vora, D Juric, N Kim, M Mino-Kenudson, T Huynh, C Costa, ...
Cancer cell 26 (1), 136-149, 2014
Autorizações: US National Institutes of Health
FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection
LM Johansen, JM Brannan, SE Delos, CJ Shoemaker, A Stossel, C Lear, ...
Science translational medicine 5 (190), 190ra79-190ra79, 2013
Autorizações: US National Institutes of Health
A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity
LM Johansen, LE DeWald, CJ Shoemaker, BG Hoffstrom, ...
Science translational medicine 7 (290), 290ra89-290ra89, 2015
Autorizações: US National Institutes of Health
Combination chemical genetics
J Lehár, BR Stockwell, G Giaever, C Nislow
Nature chemical biology 4 (11), 674-681, 2008
Autorizações: US National Institutes of Health, Canadian Institutes of Health Research
Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection
Y Suzuki, RPS Onge, R Mani, OD King, A Heilbut, VM Labunskyy, ...
Nature methods 8 (2), 159-164, 2011
Autorizações: US National Institutes of Health
Recurrent, robust and scalable patterns underlie human approach and avoidance
BW Kim, DN Kennedy, J Lehar, MJ Lee, AJ Blood, S Lee, RH Perlis, ...
PLoS One 5 (5), e10613, 2010
Autorizações: US National Institutes of Health
Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf−/− mouse model
EA Chapeau, A Gembarska, EY Durand, E Mandon, C Estadieu, ...
Proceedings of the National Academy of Sciences 114 (12), 3151-3156, 2017
Autorizações: German Research Foundation
CANDI: an R package and Shiny app for annotating radiographs and evaluating computer-aided diagnosis
MA Badgeley, M Liu, BS Glicksberg, M Shervey, J Zech, K Shameer, ...
Bioinformatics 35 (9), 1610-1612, 2019
Autorizações: US National Institutes of Health
Consistency of drug profiles and predictors in large-scale cancer cell line data
TCCL Encyclopedia, N Stransky, M Ghandi, GV Kryukov, LA Garraway, ...
Nature 528 (7580), 84, 2015
Autorizações: US National Institutes of Health, Wellcome Trust
Dual Inhibitors Targeting DNA and Histone Deacetylases
C Chen, X Yang, X Hou, H Fang
Pharmaceutical Fronts 2 (02), e88-e93, 2020
Autorizações: National Natural Science Foundation of China
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