Joseph Lehar

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Chris ImpeyProfessor of Astronomy, University of ArizonaE-mail confirmado em as.arizona.edu
Chien PengGiant Magellan Telescope OrganizationE-mail confirmado em gmto.org
Mark DalyDirector, Institute for Molecular Medicine Finland (FIMM) & Chief, ATGU, MGH & Broad InstituteE-mail confirmado em atgu.mgh.harvard.edu
PABLO TAMAYOProfessor, Division of Genomics and Precision Medicine, UC San DiegoE-mail confirmado em ucsd.edu
Todd GolubBroad InstituteE-mail confirmado em broadinstitute.org
Joel HirschhornE-mail confirmado em broadinstitute.org
David AltshulerVertex PharmaceuticalsE-mail confirmado em vrtx.com
Vamsi MoothaMassachusetts General Hospital, Harvard Medical School, HHMIE-mail confirmado em hms.harvard.edu
Nick PattersonStaff scientist, Broad InstituteE-mail confirmado em broadinstitute.org
Pere PuigserverProfessor of Cell and Cancer Biology, Harvard Medical SchoolE-mail confirmado em dfci.harvard.edu
Cecilia LindgrenThe Big Data Institute & The Wellcome Centre for Human GeneticsE-mail confirmado em bdi.ox.ac.uk
Bruce M. SpiegelmanStanley J. Korsmeyer Professor, Harvard Medical School and Dana-Farber Cancer InstituteE-mail confirmado em dfci.harvard.edu
Leif GroopE-mail confirmado em med.lu.se
Adrian HeilbutE-mail confirmado em columbia.edu
Glen LangstonProgram Director, National Science FoundationE-mail confirmado em nsf.gov
Brent R. StockwellProfessor of Biological Sciences and ChemistryE-mail confirmado em columbia.edu
Martin RidderstråleAssociate Professor of EndocrinologyE-mail confirmado em novo.dk
Manway LiuPrognomiQE-mail confirmado em google.com
David H. RobertsProfessor of Astrophysics, Brandeis UniversityE-mail confirmado em brandeis.edu
Alan HuangTango TherapeuticsE-mail confirmado em tangotx.com

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Joseph Lehar

MIT, Owkin, various biotechs and funds

E-mail confirmado em alum.mit.edu - Página inicial

Data Science Biomedical Research Astrophysics


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PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes VK Mootha, CM Lindgren, KF Eriksson, A Subramanian, S Sihag, J Lehar, ... Nature genetics 34 (3), 267-273, 2003	10557	2003
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity J Barretina, G Caponigro, N Stransky, K Venkatesan, AA Margolin, S Kim, ... Nature 483 (7391), 603-607, 2012	8146	2012
Next-generation characterization of the cancer cell line encyclopedia M Ghandi, FW Huang, J Jané-Valbuena, GV Kryukov, CC Lo, ... Nature 569 (7757), 503-508, 2019	2729	2019
High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response H Gao, JM Korn, S Ferretti, JE Monahan, Y Wang, M Singh, C Zhang, ... Nature medicine 21 (11), 1318-1325, 2015	1410	2015
Multi-target therapeutics: when the whole is greater than the sum of the parts GR Zimmermann, J Lehar, CT Keith Drug discovery today 12 (1-2), 34-42, 2007	1302	2007
Time series analysis with clean-part one-derivation of a spectrum DH Roberts, J Lehár, JW Dreher ASTRONOMICAL JOURNAL V. 93, NO. 4/APR, P. 968, 1987 93, 968, 1987	1242	1987
Synergistic drug combinations tend to improve therapeutically relevant selectivity J Lehár, AS Krueger, W Avery, AM Heilbut, LM Johansen, ER Price, ... Nature biotechnology 27 (7), 659-666, 2009	1028	2009
Systematic discovery of multicomponent therapeutics AA Borisy, PJ Elliott, NW Hurst, MS Lee, J Lehár, ER Price, G Serbedzija, ... Proceedings of the National Academy of Sciences 100 (13), 7977-7982, 2003	767	2003
Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials C Fritsch, A Huang, C Chatenay-Rivauday, C Schnell, A Reddy, M Liu, ... Molecular cancer therapeutics 13 (5), 1117-1129, 2014	511	2014
Probing the coevolution of supermassive black holes and galaxies using gravitationally lensed quasar hosts CY Peng, CD Impey, HW Rix, CS Kochanek, CR Keeton, EE Falco, ... The Astrophysical Journal 649 (2), 616, 2006	492	2006
CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors SR Vora, D Juric, N Kim, M Mino-Kenudson, T Huynh, C Costa, ... Cancer cell 26 (1), 136-149, 2014	461	2014
Automated deep-neural-network surveillance of cranial images for acute neurologic events JJ Titano, M Badgeley, J Schefflein, M Pain, A Su, M Cai, N Swinburne, ... Nature medicine 24 (9), 1337-1341, 2018	430	2018
FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection LM Johansen, JM Brannan, SE Delos, CJ Shoemaker, A Stossel, C Lear, ... Science translational medicine 5 (190), 190ra79-190ra79, 2013	391	2013
Chemical combination effects predict connectivity in biological systems J Lehár, GR Zimmermann, AS Krueger, RA Molnar, JT Ledell, AM Heilbut, ... Molecular systems biology 3 (1), 80, 2007	342	2007
Dust and extinction curves in galaxies with z> 0: the interstellar medium of gravitational lens galaxies EE Falco, CD Impey, CS Kochanek, J Lehár, BA McLeod, HW Rix, ... The Astrophysical Journal 523 (2), 617, 1999	330	1999
Pharmacogenomic agreement between two cancer cell line data sets Cancer Cell Line Encyclopedia Consortium, ... Nature 528 (7580), 84-87, 2015	294	2015
A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity LM Johansen, LE DeWald, CJ Shoemaker, BG Hoffstrom, ... Science translational medicine 7 (290), 290ra89-290ra89, 2015	264	2015
Hubble Space Telescope observations of 10 two-image gravitational lenses J Lehár, EE Falco, CS Kochanek, BA McLeod, JA Munoz, CD Impey, ... The Astrophysical Journal 536 (2), 584, 2000	260	2000
The fundamental plane of gravitational lens galaxies and the evolution of early-type galaxies in low-density environments CS Kochanek, EE Falco, CD Impey, J Lehár, BA McLeod, HW Rix, ... The Astrophysical Journal 543 (1), 131, 2000	218	2000
Combination chemical genetics J Lehár, BR Stockwell, G Giaever, C Nislow Nature chemical biology 4 (11), 674-681, 2008	205	2008

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