Artigos com autorizações de acesso público - William A McEwanSaiba mais
3 artigos não disponíveis publicamente
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TRIM21-dependent intracellular antibody neutralization of virus infection
WA McEwan, LC James
Progress in molecular biology and translational science 129, 167-187, 2015
Autorizações: UK Medical Research Council, European Commission
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Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases
Y Aman, B Ryan, SB Torsetnes, AB Knapskog, LO Watne, WA McEwan, ...
International Review of Neurobiology 155, 169-202, 2020
Autorizações: National Natural Science Foundation of China, UK Medical Research Council …
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Targeted protein degradation using intracellular antibodies and its application to neurodegenerative disease
JA Benn, AS Mukadam, WA McEwan
Seminars in Cell & Developmental Biology 126, 138-149, 2022
Autorizações: Alzheimers's UK, UK Medical Research Council, Wellcome Trust, Royal Society UK
47 artigos disponíveis publicamente
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A method for the acute and rapid degradation of endogenous proteins
D Clift, WA McEwan, LI Labzin, V Konieczny, B Mogessie, LC James, ...
Cell 171 (7), 1692-1706. e18, 2017
Autorizações: UK Medical Research Council, Wellcome Trust, European Commission
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Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21
WA McEwan, JCH Tam, RE Watkinson, SR Bidgood, DL Mallery, ...
Nature immunology 14 (4), 327-336, 2013
Autorizações: UK Medical Research Council
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Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly
AJ Price, DA Jacques, WA McEwan, AJ Fletcher, S Essig, JW Chin, ...
PLoS pathogens 10 (10), e1004459, 2014
Autorizações: US National Institutes of Health, National Health and Medical Research …
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HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis
DA Jacques, WA McEwan, L Hilditch, AJ Price, GJ Towers, LC James
Nature 536 (7616), 349-353, 2016
Autorizações: National Health and Medical Research Council, Australia, UK Medical Research …
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Intracellular sensing of complement C3 activates cell autonomous immunity
JCH Tam, SR Bidgood, WA McEwan, LC James
Science 345 (6201), 1256070, 2014
Autorizações: UK Medical Research Council, European Commission
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Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation
WA McEwan, B Falcon, M Vaysburd, D Clift, AL Oblak, B Ghetti, ...
Proceedings of the National Academy of Sciences 114 (3), 574-579, 2017
Autorizações: US National Institutes of Health, UK Medical Research Council, Wellcome Trust
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IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis
DL Mallery, CL Marquez, WA McEwan, CF Dickson, DA Jacques, ...
Elife 7, e35335, 2018
Autorizações: National Health and Medical Research Council, Australia, UK Medical Research …
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Acute and rapid degradation of endogenous proteins by Trim-Away
D Clift, C So, WA McEwan, LC James, M Schuh
Nature Protocols 13 (10), 2149-2175, 2018
Autorizações: UK Medical Research Council, Wellcome Trust, European Commission
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Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species
E Nachman, AS Wentink, K Madiona, L Bousset, T Katsinelos, K Allinson, ...
Journal of Biological Chemistry 295 (28), 9676-9690, 2020
Autorizações: Helmholtz Association, Netherlands Organisation for Scientific Research …
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Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates
JH Brelstaff, M Mason, T Katsinelos, WA McEwan, B Ghetti, AM Tolkovsky, ...
Science Advances 7 (43), eabg4980, 2021
Autorizações: US National Institutes of Health, Alzheimers's UK, UK Biotechnology and …
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TRIM21 promotes cGAS and RIG-I sensing of viral genomes during infection by antibody-opsonized virus
RE Watkinson, WA McEwan, JCH Tam, M Vaysburd, LC James
PLoS pathogens 11 (10), e1005253, 2015
Autorizações: UK Medical Research Council, European Commission
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Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells
SR Bidgood, JCH Tam, WA McEwan, DL Mallery, LC James
Proceedings of the National Academy of Sciences 111 (37), 13463-13468, 2014
Autorizações: UK Medical Research Council, European Commission
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Measurement of tau filament fragmentation provides insights into prion-like spreading
F Kundel, L Hong, B Falcon, WA McEwan, TCT Michaels, G Meisl, ...
ACS chemical neuroscience 9 (6), 1276-1282, 2018
Autorizações: Swiss National Science Foundation, UK Medical Research Council, Wellcome …
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Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat
WA McEwan, T Schaller, LM Ylinen, MJ Hosie, GJ Towers, BJ Willett
Journal of virology 83 (16), 8270-8275, 2009
Autorizações: US National Institutes of Health
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Target-induced clustering activates Trim-Away of pathogens and proteins
J Zeng, AF Santos, AS Mukadam, M Osswald, DA Jacques, CF Dickson, ...
Nature structural & molecular biology 28 (3), 278-289, 2021
Autorizações: National Health and Medical Research Council, Australia, Fundação para a …
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The role of antibodies and their receptors in protection against ordered protein assembly in neurodegeneration
T Katsinelos, BJ Tuck, AS Mukadam, WA McEwan
Frontiers in Immunology 10, 1139, 2019
Autorizações: Wellcome Trust, European Commission, Royal Society UK
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Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models
AS Mukadam, LVC Miller, AE Smith, M Vaysburd, SA Sakya, S Sanford, ...
Science 379 (6639), 1336-1341, 2023
Autorizações: Alzheimers's UK, UK Medical Research Council, National Institute for Health …
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