William A McEwan

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Leo JamesMRC Laboratory of Molecular BiologyE-mail confirmado em mrc-lmb.cam.ac.uk
Donna MalleryE-mail confirmado em mrc-lmb.cam.ac.uk
Dean CliftMRC Laboratory of Molecular BiologyE-mail confirmado em mrc-lmb.cam.ac.uk
Greg Towersuniversity college londonE-mail confirmado em ucl.ac.uk
David JacquesSchool of Biomedical Sciences, University of New South Wales, AustraliaE-mail confirmado em unsw.edu.au
Benjamin TuckResearch AssociateE-mail confirmado em mrc-lmb.cam.ac.uk
Jerry C H TamPostdoctoral Researcher at King’s College LondonE-mail confirmado em kcl.ac.uk
Ruth E WatkinsonResearch Fellow, University of ManchesterE-mail confirmado em manchester.ac.uk
Lauren V. C. MillerUniversity of CambridgeE-mail confirmado em cam.ac.uk
Michel GoedertMRC Laboratory of Molecular Biology, Cambridge, UKE-mail confirmado em mrc-lmb.cam.ac.uk
Claire F DicksonUNSWE-mail confirmado em unsw.edu.au
Margaret J HosieProfessor of Comparative Virology, University of GlasgowE-mail confirmado em glasgow.ac.uk
Georg MeislUniversity of CambridgeE-mail confirmado em cam.ac.uk
Benjamin Ryskeldi-FalconGroup Leader, MRC Laboratory of Molecular Biology (LMB)E-mail confirmado em mrc-lmb.cam.ac.uk
Binyam MogessieAssistant Professor of Molecular, Cellular, and Developmental Biology, and of OBGYN, Yale UniversityE-mail confirmado em yale.edu
Larisa LabzinInstitute for Molecular Bioscience, University of Queensland.E-mail confirmado em uq.edu.au
Maria Grazia SpillantiniUniversity of CambridgeE-mail confirmado em cam.ac.uk
H.H. KampingaProfessor in Cell BiologyE-mail confirmado em rug.nl
Carmen Nussbaum-KrammerLudwig-Maximilians-UniversityE-mail confirmado em med.uni-muenchen.de
Adam J. FletcherMRC University of Glasgow Centre for Virus ResearchE-mail confirmado em glasgow.ac.uk

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William A McEwan

UK Dementia Research Institute, University of Cambridge

E-mail confirmado em cam.ac.uk - Página inicial

Protein misfolding Neurodegeneration Virology Microbiology Immunology


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Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21) DL Mallery, WA McEwan, SR Bidgood, GJ Towers, CM Johnson, ... Proceedings of the National Academy of Sciences 107 (46), 19985-19990, 2010	570	2010
A method for the acute and rapid degradation of endogenous proteins D Clift, WA McEwan, LI Labzin, V Konieczny, B Mogessie, LC James, ... Cell 171 (7), 1692-1706. e18, 2017	489	2017
Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21 WA McEwan, JCH Tam, RE Watkinson, SR Bidgood, DL Mallery, ... Nature immunology 14 (4), 327-336, 2013	417	2013
Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly AJ Price, DA Jacques, WA McEwan, AJ Fletcher, S Essig, JW Chin, ... PLoS pathogens 10 (10), e1004459, 2014	299	2014
HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis DA Jacques, WA McEwan, L Hilditch, AJ Price, GJ Towers, LC James Nature 536 (7616), 349-353, 2016	259	2016
Intracellular sensing of complement C3 activates cell autonomous immunity JCH Tam, SR Bidgood, WA McEwan, LC James Science 345 (6201), 1256070, 2014	198	2014
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation WA McEwan, B Falcon, M Vaysburd, D Clift, AL Oblak, B Ghetti, ... Proceedings of the National Academy of Sciences 114 (3), 574-579, 2017	182	2017
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis DL Mallery, CL Marquez, WA McEwan, CF Dickson, DA Jacques, ... Elife 7, e35335, 2018	179	2018
Acute and rapid degradation of endogenous proteins by Trim-Away D Clift, C So, WA McEwan, LC James, M Schuh Nature Protocols 13 (10), 2149-2175, 2018	153	2018
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species E Nachman, AS Wentink, K Madiona, L Bousset, T Katsinelos, K Allinson, ... Journal of Biological Chemistry 295 (28), 9676-9690, 2020	142	2020
AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization F Hauler, DL Mallery, WA McEwan, SR Bidgood, LC James Proceedings of the National Academy of Sciences 109 (48), 19733-19738, 2012	110	2012
Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates JH Brelstaff, M Mason, T Katsinelos, WA McEwan, B Ghetti, AM Tolkovsky, ... Science Advances 7 (43), eabg4980, 2021	107	2021
TRIM21 promotes cGAS and RIG-I sensing of viral genomes during infection by antibody-opsonized virus RE Watkinson, WA McEwan, JCH Tam, M Vaysburd, LC James PLoS pathogens 11 (10), e1005253, 2015	105	2015
Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells SR Bidgood, JCH Tam, WA McEwan, DL Mallery, LC James Proceedings of the National Academy of Sciences 111 (37), 13463-13468, 2014	97	2014
Regulation of virus neutralization and the persistent fraction by TRIM21 WA McEwan, F Hauler, CR Williams, SR Bidgood, DL Mallery, ... Journal of virology 86 (16), 8482-8491, 2012	97	2012
Measurement of tau filament fragmentation provides insights into prion-like spreading F Kundel, L Hong, B Falcon, WA McEwan, TCT Michaels, G Meisl, ... ACS chemical neuroscience 9 (6), 1276-1282, 2018	92	2018
Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat WA McEwan, T Schaller, LM Ylinen, MJ Hosie, GJ Towers, BJ Willett Journal of virology 83 (16), 8270-8275, 2009	77	2009
Intracellular antibody‐mediated immunity and the role of TRIM21 WA McEwan, DL Mallery, DA Rhodes, J Trowsdale, LC James BioEssays, 2011	70	2011
Target-induced clustering activates Trim-Away of pathogens and proteins J Zeng, AF Santos, AS Mukadam, M Osswald, DA Jacques, CF Dickson, ... Nature structural & molecular biology 28 (3), 278-289, 2021	68	2021
The role of antibodies and their receptors in protection against ordered protein assembly in neurodegeneration T Katsinelos, BJ Tuck, AS Mukadam, WA McEwan Frontiers in Immunology 10, 1139, 2019	51	2019

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