| SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function NL Price, AP Gomes, AJY Ling, FV Duarte, A Martin-Montalvo, BJ North, ... Cell metabolism 15 (5), 675-690, 2012 | 1735 | 2012 |
| Metformin improves healthspan and lifespan in mice A Martin-Montalvo, EM Mercken, SJ Mitchell, HH Palacios, PL Mote, ... Nature communications 4 (1), 2192, 2013 | 1560 | 2013 |
| Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging AP Gomes, NL Price, AJY Ling, JJ Moslehi, MK Montgomery, L Rajman, ... Cell 155 (7), 1624-1638, 2013 | 1559 | 2013 |
| Evidence for a common mechanism of SIRT1 regulation by allosteric activators BP Hubbard, AP Gomes, H Dai, J Li, AW Case, T Considine, TV Riera, ... Science 339 (6124), 1216-1219, 2013 | 677 | 2013 |
| Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy AV Hafner, J Dai, AP Gomes, CY Xiao, CM Palmeira, A Rosenzweig, ... Aging (Albany NY) 2 (12), 914, 2010 | 602 | 2010 |
| Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome C Escande, V Nin, NL Price, V Capellini, AP Gomes, MT Barbosa, ... Diabetes 62 (4), 1084-1093, 2013 | 386 | 2013 |
| SRT1720 improves survival and healthspan of obese mice RK Minor, JA Baur, AP Gomes, TM Ward, A Csiszar, EM Mercken, ... Scientific reports 1 (1), 70, 2011 | 342 | 2011 |
| Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers E Mullarky, NC Lucki, R Beheshti Zavareh, JL Anglin, AP Gomes, ... Proceedings of the National Academy of Sciences 113 (7), 1778-1783, 2016 | 321 | 2016 |
| SRT 2104 extends survival of male mice on a standard diet and preserves bone and muscle mass EM Mercken, SJ Mitchell, A Martin‐Montalvo, RK Minor, M Almeida, ... Aging cell 13 (5), 787-796, 2014 | 262 | 2014 |
| Age-induced accumulation of methylmalonic acid promotes tumour progression AP Gomes, D Ilter, V Low, JE Endress, J Fernández-García, ... Nature 585 (7824), 283-287, 2020 | 196 | 2020 |
| Unique metabolic adaptations dictate distal organ-specific metastatic colonization T Schild, V Low, J Blenis, AP Gomes Cancer cell 33 (3), 347-354, 2018 | 183 | 2018 |
| Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis AP Gomes, FV Duarte, P Nunes, BP Hubbard, JS Teodoro, AT Varela, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1822 (2), 185-195, 2012 | 170 | 2012 |
| Measurement of the production cross section of prompt J/psi mesons in association with a W boson in pp collisions at sqrt {s}= 7 TeV with the ATLAS detector ATLAS collaboration arXiv preprint arXiv:1401.2831, 2014 | 161 | 2014 |
| The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression MX Miranda, LJ Van Tits, C Lohmann, T Arsiwala, S Winnik, A Tailleux, ... European heart journal 36 (1), 51-59, 2015 | 159 | 2015 |
| mTORC1 promotes metabolic reprogramming by the suppression of GSK3-dependent Foxk1 phosphorylation L He, AP Gomes, X Wang, SO Yoon, G Lee, MJ Nagiec, S Cho, A Chavez, ... Molecular cell 70 (5), 949-960. e4, 2018 | 146 | 2018 |
| Beyond the Warburg effect: how do cancer cells regulate one-carbon metabolism? A Rosenzweig, J Blenis, AP Gomes Frontiers in cell and developmental biology 6, 90, 2018 | 134 | 2018 |
| Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: a possible role for SirT3 activation JS Teodoro, FV Duarte, AP Gomes, AT Varela, FM Peixoto, AP Rolo, ... Mitochondrion 13 (6), 637-646, 2013 | 126 | 2013 |
| A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways AP Gomes, J Blenis Current opinion in biotechnology 34, 110-117, 2015 | 105 | 2015 |
| Dynamic incorporation of histone H3 variants into chromatin is essential for acquisition of aggressive traits and metastatic colonization AP Gomes, D Ilter, V Low, A Rosenzweig, ZJ Shen, T Schild, MA Rivas, ... Cancer Cell 36 (4), 402-417. e13, 2019 | 88 | 2019 |
| Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis LE Wu, AP Gomes, DA Sinclair Cancer cell 25 (1), 12-19, 2014 | 82 | 2014 |
David A. SinclairHarvard Medical School (Genetics)E-mail confirmado em hms.harvard.edu