A single-cell transcriptomic atlas characterizes ageing tissues in the mouse Nature 583 (7817), 590-595, 2020 | 889 | 2020 |
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease D Gate, N Saligrama, O Leventhal, AC Yang, MS Unger, J Middeldorp, ... Nature 577 (7790), 399-404, 2020 | 703 | 2020 |
Dysregulation of brain and choroid plexus cell types in severe COVID-19 AC Yang, F Kern, PM Losada, MR Agam, CA Maat, GP Schmartz, ... Nature 595 (7868), 565-571, 2021 | 585 | 2021 |
A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk AC Yang, RT Vest, F Kern, DP Lee, M Agam, CA Maat, PM Losada, ... Nature 603 (7903), 885-892, 2022 | 506 | 2022 |
Ageing hallmarks exhibit organ-specific temporal signatures N Schaum, B Lehallier, O Hahn, R Pálovics, S Hosseinzadeh, SE Lee, ... Nature 583 (7817), 596-602, 2020 | 453 | 2020 |
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains JV Pluvinage, MS Haney, BAH Smith, J Sun, T Iram, L Bonanno, L Li, ... Nature 568 (7751), 187-192, 2019 | 366 | 2019 |
Physiological blood–brain transport is impaired with age by a shift in transcytosis AC Yang, MY Stevens, MB Chen, DP Lee, D Stähli, D Gate, K Contrepois, ... Nature 583 (7816), 425-430, 2020 | 360 | 2020 |
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1 H Yousef, CJ Czupalla, D Lee, MB Chen, AN Burke, KA Zera, J Zandstra, ... Nature medicine 25 (6), 988-1000, 2019 | 336 | 2019 |
Engineering phage host-range and suppressing bacterial resistance through phage tail fiber mutagenesis K Yehl, S Lemire, AC Yang, H Ando, M Mimee, MDT Torres, ... Cell 179 (2), 459-469. e9, 2019 | 312 | 2019 |
Exercise plasma boosts memory and dampens brain inflammation via clusterin Z De Miguel, N Khoury, MJ Betley, B Lehallier, D Willoughby, N Olsson, ... Nature 600 (7889), 494-499, 2021 | 261 | 2021 |
An exercise-inducible metabolite that suppresses feeding and obesity VL Li, Y He, K Contrepois, H Liu, JT Kim, AL Wiggenhorn, JT Tanzo, ... Nature 606 (7915), 785-790, 2022 | 187 | 2022 |
Brain endothelial cells are exquisite sensors of age-related circulatory cues MB Chen, AC Yang, H Yousef, D Lee, W Chen, N Schaum, B Lehallier, ... Cell reports 30 (13), 4418-4432. e4, 2020 | 168 | 2020 |
Organ aging signatures in the plasma proteome track health and disease HSH Oh, J Rutledge, D Nachun, R Pálovics, O Abiose, P Moran-Losada, ... Nature 624 (7990), 164-172, 2023 | 152 | 2023 |
Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17 T Iram, F Kern, A Kaur, S Myneni, AR Morningstar, H Shin, MA Garcia, ... Nature 605 (7910), 509-515, 2022 | 144 | 2022 |
CD4+ T cells contribute to neurodegeneration in Lewy body dementia D Gate, E Tapp, O Leventhal, M Shahid, TJ Nonninger, AC Yang, ... Science 374 (6569), 868-874, 2021 | 134 | 2021 |
Cell type-selective secretome profiling in vivo W Wei, NM Riley, AC Yang, JT Kim, SM Terrell, VL Li, M Garcia-Contreras, ... Nature chemical biology 17 (3), 326-334, 2021 | 91 | 2021 |
Molecular hallmarks of heterochronic parabiosis at single-cell resolution R Pálovics, A Keller, N Schaum, W Tan, T Fehlmann, M Borja, F Kern, ... Nature 603 (7900), 309-314, 2022 | 88 | 2022 |
Synthetic bacteriophages and bacteriophage compositions TKT Lu, S LIMERE | 36 | 2018 |
Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration RT Vest, CC Chou, H Zhang, MS Haney, L Li, NN Laqtom, B Chang, ... Proceedings of the National Academy of Sciences 119 (11), e2121609119, 2022 | 31 | 2022 |
Multiple click-selective tRNA synthetases expand mammalian cell-specific proteomics AC Yang, H Du Bois, N Olsson, D Gate, B Lehallier, D Berdnik, KD Brewer, ... Journal of the American Chemical Society 140 (23), 7046-7051, 2018 | 29 | 2018 |