| Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans P Ulrichts, A Guglietta, T Dreier, T van Bragt, V Hanssens, E Hofman, ... The Journal of clinical investigation 128 (10), 4372-4386, 2018 | 285 | 2018 |
| Prevention of oculopharyngeal muscular dystrophy-associated aggregation of nuclear poly (A)-binding protein with a single-domain intracellular antibody P Verheesen, A de Kluijver, S van Koningsbruggen, M de Brij, ... Human molecular genetics 15 (1), 105-111, 2006 | 106 | 2006 |
| Beneficial properties of single-domain antibody fragments for application in immunoaffinity purification and immuno-perfusion chromatography P Verheesen, MR Ten Haaft, N Lindner, CT Verrips, JJW De Haard Biochimica et Biophysica Acta (BBA)-General Subjects 1624 (1-3), 21-28, 2003 | 96 | 2003 |
| Reliable and controllable antibody fragment selections from Camelid non-immune libraries for target validation P Verheesen, A Roussis, HJ de Haard, AJ Groot, JC Stam, ... Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1764 (8), 1307-1319, 2006 | 86 | 2006 |
| Protein studies in dysferlinopathy patients using llama-derived antibody fragments selected by phage display Y Huang, P Verheesen, A Roussis, W Frankhuizen, I Ginjaar, F Haldane, ... European journal of human genetics 13 (6), 721-730, 2005 | 84 | 2005 |
| Method and apparatus for receiving diversity signals for use in OFDM radio communication system K Sato, M Namekata US Patent 7,266,108, 2007 | 80* | 2007 |
| Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction E Regan-Klapisz, I Sorokina, J Voortman, P de Keizer, RC Roovers, ... Journal of cell science 118 (19), 4437-4450, 2005 | 79 | 2005 |
| Treatment of pemphigus vulgaris and foliaceus with efgartigimod, a neonatal Fc receptor inhibitor: a phase II multicentre, open‐label feasibility trial M Goebeler, Z Bata‐Csörgő, C De Simone, B Didona, E Remenyik, ... British Journal of Dermatology 186 (3), 429-439, 2022 | 73 | 2022 |
| Polypeptides that modulate the interaction between cells of the immune system G Hermans, P Verheesen, E Dolk, HRJM Hoogenboom, MJS Saunders, ... US Patent 8,907,065, 2014 | 55* | 2014 |
| Identification by phage display of single-domain antibody fragments specific for the ODD domain in hypoxia-inducible factor 1alpha AJ Groot, P Verheesen, EJ Westerlaken, EH Gort, P Van Der Groep, ... Laboratory investigation 86 (4), 345-356, 2006 | 51 | 2006 |
| Selection and characterization of KDEL-specific VHH antibody fragments and their application in the study of ER resident protein expression R Klooster, MR Eman, Q le Duc, P Verheesen, CT Verrips, RC Roovers, ... Journal of immunological methods 342 (1-2), 1-12, 2009 | 41 | 2009 |
| FcRn antagonism leads to a decrease of desmoglein-specific B cells: secondary analysis of a phase 2 study of efgartigimod in pemphigus vulgaris and pemphigus foliaceus M Maho-Vaillant, M Sips, ML Golinski, G Vidarsson, M Goebeler, ... Frontiers in Immunology 13, 863095, 2022 | 25 | 2022 |
| The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement M Brinkhaus, E Pannecoucke, EJ van der Kooi, AEH Bentlage, ... Nature communications 13 (1), 6073, 2022 | 24 | 2022 |
| Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same HAP Revets, C Boutton, S Staelens, P Verheesen US Patent App. 13/018,047, 2011 | 23 | 2011 |
| Amino acid sequences that modulate the interaction between cells of the immune system G Hermans, P Verheesen, E Dolk, HRJM Hoogenboom, MJS Saunders, ... US Patent App. 14/528,566, 2015 | 18 | 2015 |
| Selection by phage display of single domain antibodies specific to antigens in their native conformation P Verheesen, T Laeremans Single Domain Antibodies: Methods and Protocols, 81-104, 2012 | 18 | 2012 |
| Glycine 236 in the lower hinge region of human IgG1 differentiates FcγR from complement effector function M Brinkhaus, RGJ Douwes, AEH Bentlage, AR Temming, SW de Taeye, ... The Journal of Immunology 205 (12), 3456-3467, 2020 | 17 | 2020 |
| Amino acid sequences that modulate the interaction between cells of the immune system G Hermans, P Verheesen, E Dolk, HRJM Hoogenboom, MJS Saunders, ... US Patent 10,087,251, 2018 | 17 | 2018 |
| Stabilization of keratinocyte monolayer integrity in the presence of anti-desmoglein-3 antibodies through FcRn blockade with efgartigimod: novel treatment paradigm for pemphigus? A Zakrzewicz, C Würth, B Beckert, S Feldhoff, K Vanderheyden, S Foss, ... Cells 11 (6), 942, 2022 | 16 | 2022 |
| Fungal glucosylceramide-specific camelid single domain antibodies are characterized by broad spectrum antifungal activity B De Coninck, P Verheesen, CM Vos, I Van Daele, MF De Bolle, JV Vieira, ... Frontiers in Microbiology 8, 1059, 2017 | 14 | 2017 |
Silvère van der MaarelProfessor of Medical Epigenetics, Head of Department, Human Genetics, Leiden University MedicalZweryfikowany adres z lumc.nl
