| Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation AR Choudhury, Z Ju, MW Djojosubroto, A Schienke, A Lechel, ... Nature genetics 39 (1), 99-105, 2007 | 521 | 2007 |
| A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage J Wang, Q Sun, Y Morita, H Jiang, A Groß, A Lechel, K Hildner, ... Cell 148 (5), 1001-1014, 2012 | 392 | 2012 |
| Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors S Schwitalla, PK Ziegler, D Horst, V Becker, I Kerle, Y Begus-Nahrmann, ... Cancer cell 23 (1), 93-106, 2013 | 319 | 2013 |
| p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer DF Tschaharganeh, W Xue, DF Calvisi, M Evert, TV Michurina, LE Dow, ... Cell 158 (3), 579-592, 2014 | 256 | 2014 |
| Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling M Hohwieler, A Illing, PC Hermann, T Mayer, M Stockmann, L Perkhofer, ... Gut 66 (3), 473-486, 2017 | 234 | 2017 |
| Telomerase gene mutations are associated with cirrhosis formation D Hartmann, U Srivastava, M Thaler, KN Kleinhans, G N'kontchou, ... Hepatology 53 (5), 1608-1617, 2011 | 211 | 2011 |
| Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis RR Plentz, YN Park, A Lechel, H Kim, F Nellessen, BHE Langkopf, ... Hepatology 45 (4), 968-976, 2007 | 175 | 2007 |
| Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice S Schaetzlein, NR Kodandaramireddy, Z Ju, A Lechel, A Stepczynska, ... Cell 130 (5), 863-877, 2007 | 171 | 2007 |
| Telomeres shorten while Tert expression increases during ageing of the short-lived fish Nothobranchius furzeri N Hartmann, K Reichwald, A Lechel, M Graf, J Kirschner, A Dorn, ... Mechanisms of ageing and development 130 (5), 290-296, 2009 | 153 | 2009 |
| Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition R Russell, L Perkhofer, S Liebau, Q Lin, A Lechel, FM Feld, E Hessmann, ... Nature communications 6 (1), 7677, 2015 | 152 | 2015 |
| Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals S Schwoerer, F Becker, C Feller, AH Baig, U Koeber, H Henze, JM Kraus, ... Nature 540 (7633), 428-432, 2016 | 136 | 2016 |
| The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo A Lechel, A Satyanarayana, Z Ju, RR Plentz, S Schaetzlein, C Rudolph, ... EMBO reports 6 (3), 275-281, 2005 | 128 | 2005 |
| p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice Y Begus-Nahrmann, A Lechel, AC Obenauf, K Nalapareddy, E Peit, ... Nature genetics 41 (10), 1138-1143, 2009 | 124 | 2009 |
| Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation SF Katz, A Lechel, AC Obenauf, Y Begus–Nahrmann, JM Kraus, ... Gastroenterology 142 (5), 1229-1239. e3, 2012 | 118 | 2012 |
| ATM deficiency generating genomic instability sensitizes pancreatic ductal adenocarcinoma cells to therapy-induced DNA damage L Perkhofer, A Schmitt, MC Romero Carrasco, M Ihle, S Hampp, ... Cancer research 77 (20), 5576-5590, 2017 | 111 | 2017 |
| Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage S Tao, D Tang, Y Morita, T Sperka, O Omrani, A Lechel, V Sakk, J Kraus, ... The EMBO journal 34 (5), 624-640, 2015 | 95 | 2015 |
| Preclinical characterization of novel chordoma cell systems and their targeting by pharmocological inhibitors of the CDK4/6 cell-cycle pathway A von Witzleben, LT Goerttler, R Marienfeld, H Barth, A Lechel, K Mellert, ... Cancer research 75 (18), 3823-3831, 2015 | 92 | 2015 |
| Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease A Lechel, H Holstege, Y Begus, A Schienke, K Kamino, U Lehmann, ... Gastroenterology 132 (4), 1465-1475, 2007 | 89 | 2007 |
| Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis Y Begus-Nahrmann, D Hartmann, J Kraus, P Eshraghi, A Scheffold, ... The Journal of clinical investigation 122 (6), 2283-2288, 2021 | 83 | 2021 |
| Protein kinase D1, reduced in human pancreatic tumors, increases secretion of small extracellular vesicles from cancer cells that promote metastasis to lung in mice M Armacki, S Polaschek, M Waldenmaier, M Morawe, C Ruhland, ... Gastroenterology 159 (3), 1019-1035. e22, 2020 | 73 | 2020 |
