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Paul C. Klauser
Tytuł
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Developing covalent protein drugs via proximity-enabled reactive therapeutics
Q Li, Q Chen, PC Klauser, M Li, F Zheng, N Wang, X Li, Q Zhang, X Fu, ...
Cell 182 (1), 85-97. e16, 2020
1592020
DNA-catalyzed amide hydrolysis
C Zhou, JL Avins, PC Klauser, BM Brandsen, Y Lee, SK Silverman
Journal of the American Chemical Society 138 (7), 2106-2109, 2016
832016
A Genetically Encoded Fluorosulfonyloxybenzoyl-l-lysine for Expansive Covalent Bonding of Proteins via SuFEx Chemistry
J Liu, L Cao, PC Klauser, R Cheng, VY Berdan, W Sun, N Wang, ...
Journal of the American Chemical Society 143 (27), 10341-10351, 2021
772021
Covalent peptides and proteins for therapeutics
VY Berdan, PC Klauser, L Wang
Bioorganic & Medicinal Chemistry 29, 115896, 2021
512021
Genetically encoded quinone methides enabling rapid, site-specific, and photocontrolled protein modification with amine reagents
J Liu, R Cheng, N Van Eps, N Wang, T Morizumi, WL Ou, PC Klauser, ...
Journal of the American Chemical Society 142 (40), 17057-17068, 2020
372020
DNA-catalyzed DNA cleavage by a radical pathway with well-defined products
Y Lee, PC Klauser, BM Brandsen, C Zhou, X Li, SK Silverman
Journal of the American Chemical Society 139 (1), 255-261, 2017
272017
Covalent proteins as targeted radionuclide therapies enhance antitumor effects
PC Klauser, S Chopra, L Cao, KN Bobba, B Yu, Y Seo, E Chan, ...
ACS Central Science 9 (6), 1241-1251, 2023
222023
The proximity-enabled sulfur fluoride exchange reaction in the protein context
B Yu, L Cao, S Li, PC Klauser, L Wang
Chemical Science 14 (29), 7913-7921, 2023
142023
Encoding latent SuFEx reactive meta-fluorosulfate tyrosine to expand covalent bonding of proteins
PC Klauser, VY Berdan, L Cao, L Wang
Chemical Communications 58 (48), 6861-6864, 2022
122022
Arginine accelerates sulfur fluoride exchange and phosphorus fluoride exchange reactions between proteins
L Cao, B Yu, PC Klauser, P Zhang, S Li, L Wang
Angewandte Chemie 136 (47), e202412843, 2024
32024
Bioreactive proteins containing unnatural amino acids
L Wang, W Sun, PC Klauser, L Cao, YU Bingchen, N Wang, S Li, ...
US Patent App. 18/288,679, 2024
2024
Developing Covalent Biologics Through Genetic Code Expansion for Cancer Therapeutics
PC Klauser
University of California, San Francisco, 2023
2023
DNA Enzymes for Amide Bond Cleavage and for DNA Cleavage by a Radical Pathway
PC Klauser
University of Illinois at Urbana-Champaign, 2017
2017
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