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Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase M Tewari, LT Quan, K O'Rourke, S Desnoyers, Z Zeng, DR Beidler, ... Cell 81 (5), 801-809, 1995 | 3045 | 1995 |
Specific proteolytic cleavage of poly (ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis SH Kaufmann, S Desnoyers, Y Ottaviano, NE Davidson, GG Poirier Cancer research 53 (17), 3976-3985, 1993 | 2626 | 1993 |
Poly (ADP-ribosyl) ation reactions in the regulation of nuclear functions D d'AMOURS, S Desnoyers, I d'SILVA, GG Poirier Biochemical journal 342 (2), 249-268, 1999 | 2478 | 1999 |
Mediation of poly (ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor SW Yu, H Wang, MF Poitras, C Coombs, WJ Bowers, HJ Federoff, ... Science 297 (5579), 259-263, 2002 | 2318 | 2002 |
PARP inhibition: PARP1 and beyond M Rouleau, A Patel, MJ Hendzel, SH Kaufmann, GG Poirier Nature reviews cancer 10 (4), 293-301, 2010 | 1626 | 2010 |
Apoptosis-inducing factor mediates poly (ADP-ribose)(PAR) polymer-induced cell death SW Yu, SA Andrabi, H Wang, NS Kim, GG Poirier, TM Dawson, ... Proceedings of the National Academy of Sciences 103 (48), 18314-18319, 2006 | 905 | 2006 |
Post-translational modification of poly (ADP-ribose) polymerase induced by DNA strand breaks T Lindahl, MS Satoh, GG Poirier, A Klungland Trends in biochemical sciences 20 (10), 405-411, 1995 | 852 | 1995 |
Poly (ADP-ribose)(PAR) polymer is a death signal SA Andrabi, NS Kim, SW Yu, H Wang, DW Koh, M Sasaki, JA Klaus, ... Proceedings of the National Academy of Sciences 103 (48), 18308-18313, 2006 | 776 | 2006 |
Molecular Ordering of the Cell Death Pathway: Bcl-2 AND Bcl-xL Function upstream of the CED-3-like apoptotic proteases (∗) AM Chinnaiyan, K Orth, K O'Rourke, H Duan, GG Poirier, VM Dixit Journal of Biological Chemistry 271 (9), 4573-4576, 1996 | 766 | 1996 |
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites JF Haince, D McDonald, A Rodrigue, U Déry, JY Masson, MJ Hendzel, ... Journal of Biological Chemistry 283 (2), 1197-1208, 2008 | 756 | 2008 |
Poly (ADP-ribosyl) ation of polynucleosomes causes relaxation of chromatin structure. GG Poirier, G De Murcia, J Jongstra-Bilen, C Niedergang, P Mandel Proceedings of the National Academy of Sciences 79 (11), 3423-3427, 1982 | 731 | 1982 |
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in … A Takahashi, ES Alnemri, YA Lazebnik, T Fernandes-Alnemri, G Litwack, ... Proceedings of the National Academy of Sciences 93 (16), 8395-8400, 1996 | 710 | 1996 |
Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. YA Lazebnik, A Takahashi, RD Moir, RD Goldman, GG Poirier, ... Proceedings of the National Academy of Sciences 92 (20), 9042-9046, 1995 | 691 | 1995 |
Zinc is a potent inhibitor of the apoptotic protease, caspase-3: a novel target for zinc in the inhibition of apoptosis DK Perry, MJ Smyth, HR Stennicke, GS Salvesen, P Duriez, GG Poirier, ... Journal of Biological Chemistry 272 (30), 18530-18533, 1997 | 641 | 1997 |
Cleavage of automodified poly (ADP-ribose) polymerase during apoptosis: evidence for involvement of caspase-7 M Germain, EB Affar, D D'Amours, VM Dixit, GS Salvesen, GG Poirier Journal of Biological Chemistry 274 (40), 28379-28384, 1999 | 574 | 1999 |
PARP-1, a determinant of cell survival in response to DNA damage VJ Bouchard, M Rouleau, GG Poirier Experimental hematology 31 (6), 446-454, 2003 | 530 | 2003 |
Poly (ADP-ribose)(PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1–dependent cell death (parthanatos) Y Wang, NS Kim, JF Haince, HC Kang, KK David, SA Andrabi, GG Poirier, ... Science signaling 4 (167), ra20-ra20, 2011 | 521 | 2011 |
ATM‐dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post‐translational activation of p53 protein involving poly (ADP‐ribose) polymerase H Vaziri, MD West, RC Allsopp, TS Davison, YS Wu, CH Arrowsmith, ... The EMBO journal, 1997 | 520 | 1997 |
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme C Jeronimo, D Forget, A Bouchard, Q Li, G Chua, C Poitras, C Thérien, ... Molecular cell 27 (2), 262-274, 2007 | 509 | 2007 |