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Armiyaw Sebastian Nasamu
Armiyaw Sebastian Nasamu
Post-doctoral fellow, Seattle Children's Research Institute, CGIDR
Zweryfikowany adres z seattlechildrens.org
Tytuł
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Cytowane przez
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A genome-wide CRISPR screen in Toxoplasma identifies essential apicomplexan genes
SM Sidik, D Huet, SM Ganesan, MH Huynh, T Wang, AS Nasamu, P Thiru, ...
Cell 166 (6), 1423-1435. e12, 2016
8252016
Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites
SM Ganesan, A Falla, SJ Goldfless, AS Nasamu, JC Niles
Nature communications 7 (1), 10727, 2016
2012016
Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion
AS Nasamu, S Glushakova, I Russo, B Vaupel, A Oksman, AS Kim, ...
Science 358 (6362), 518-522, 2017
1912017
Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy
A Chalkiadaki, M Igarashi, AS Nasamu, J Knezevic, L Guarente
PLoS genetics 10 (7), e1004490, 2014
1652014
EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX
M Garten, AS Nasamu, JC Niles, J Zimmerberg, DE Goldberg, JR Beck
Nature microbiology 3 (10), 1090-1098, 2018
1332018
Malaria parasite plasmepsins: More than just plain old degradative pepsins
AS Nasamu, AJ Polino, ES Istvan, DE Goldberg
Journal of Biological Chemistry 295 (25), 8425-8441, 2020
872020
An integrated platform for genome engineering and gene expression perturbation in Plasmodium falciparum
AS Nasamu, A Falla, CFA Pasaje, BA Wall, JC Wagner, SM Ganesan, ...
Scientific reports 11 (1), 342, 2021
482021
Rounding precedes rupture and breakdown of vacuolar membranes minutes before malaria parasite egress from erythrocytes
S Glushakova, JR Beck, M Garten, BL Busse, AS Nasamu, ...
Cellular microbiology 20 (10), e12868, 2018
432018
Complex nutrient channel phenotypes despite Mendelian inheritance in a Plasmodium falciparum genetic cross
A Gupta, AAB Bokhari, AD Pillai, AK Crater, J Gezelle, G Saggu, ...
PLoS pathogens 16 (2), e1008363, 2020
412020
Assessment of Biological Role and Insight into Druggability of the Plasmodium falciparum Protease Plasmepsin V
AJ Polino, AS Nasamu, JC Niles, DE Goldberg
ACS Infectious Diseases 6 (4), 738-746, 2020
372020
Fast-acting small molecules targeting malarial aspartyl proteases, plasmepsins, inhibit malaria infection at multiple life stages
S Singh, V Rajendran, J He, AK Singh, AO Achieng, Vandana, A Pant, ...
ACS Infectious Diseases 5 (2), 184-198, 2018
222018
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation
S Bopp, CFA Pasaje, RL Summers, P Magistrado-Coxen, KA Schindler, ...
Nature Communications 14 (1), 1455, 2023
212023
4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl-N-benzylpyrrolidine-3-carboxamides
MJ Meyers, J Liu, J Xu, F Leng, J Guan, Z Liu, SA McNitt, L Qin, L Dai, ...
Journal of medicinal chemistry 62 (7), 3503-3512, 2019
202019
Activation of the Plasmodium Egress Effector Subtilisin-Like Protease 1 Is Mediated by Plasmepsin X Destruction of the Prodomain
S Mukherjee, AS Nasamu, KC Rubiano, DE Goldberg
Mbio 14 (2), e00673-23, 2023
112023
GeneTargeter: Automated In Silico Design for Genome Editing in the Malaria Parasite, Plasmodium falciparum
P Cárdenas, LY Esherick, G Chambonnier, S Dey, CV Turlo, AS Nasamu, ...
The CRISPR journal 5 (1), 155-164, 2022
72022
Exp2 in the role of the small molecule pore in the parasitophorous vacuole membrane of Plasmodium falciparum
M Garten, JR Beck, S Glushakova, AS Nasamu, JC Niles, DE Goldberg, ...
Biophysical Journal 114 (3), 492a, 2018
22018
Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis
AM Blackwell, Y Jami-Alahmadi, AS Nasamu, S Kudo, A Senoo, C Slam, ...
Elife 13, RP100256, 2024
12024
A NATURAL VARIANT IN PLASMODIUM FALCIPARUM ACYL CO-A SYNTHETASE 10 CONFERS RESISTANCE TO NOVEL ANTIMALARIALS
S Bopp, C Pasaje, P Magistrado-Coxen, R Summers, VC Lopez, S Dey, ...
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 105 (5), 61-62, 2021
2021
The roles of plasmepsins IX and X in malaria parasite biology
AS Nasamu
Washington University in St. Louis, 2021
2021
Fast-acting small molecules targeting malarial aspartyl proteases, plasmepsins, inhibit malaria infection at multiple life stages.
SS Snigdha Singh, VR Vinoth Rajendran, JH Jiang He, AK Singh, ...
2019
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