Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine A Sparreboom, J Van Asperen, U Mayer, AH Schinkel, JW Smit, ... Proceedings of the National Academy of Sciences 94 (5), 2031-2035, 1997 | 1138 | 1997 |
Antiviral activities of lactoferrin BWA Van der Strate, L Beljaars, G Molema, MC Harmsen, DKF Meijer Antiviral research 52 (3), 225-239, 2001 | 672 | 2001 |
Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport RPJO Elferink, DKF Meijer, F Kuipers, PLM Jansen, AK Groen, ... Biochimica et Biophysica Acta (BBA)-Reviews on Biomembranes 1241 (2), 215-268, 1995 | 503 | 1995 |
Antiviral effects of plasma and milk proteins: lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro MC Harmsen, PJ Swart, MP Béthune, R Pauwels, ED Clercq, TB The, ... Journal of Infectious Diseases 172 (2), 380-388, 1995 | 498 | 1995 |
Up–Regulation of the Multidrug Resistance Genes, Mrp1AndMdr1b, and Down–Regulation of the Organic Anion Transporter, Mrp2, and the Bile Salt Transporter, Spgp, in Endotoxemic … TA Vos, GJ Hooiveld, H Koning, S Childs, DK Meijer, H Moshage, ... Hepatology 28 (6), 1637-1644, 1998 | 457 | 1998 |
MW/Pharm, an integrated software package for drug dosage regimen calculation and therapeutic drug monitoring JH Proost, DKF Meijer Computers in biology and medicine 22 (3), 155-163, 1992 | 385 | 1992 |
Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein U Mayer, E Wagenaar, JH Beijnen, JW Smit, DK Meijer, J van Asperen, ... British Journal of Pharmacology 119 (5), 1038, 1996 | 372 | 1996 |
Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1 JE van Montfoort, B Stieger, DKF Meijer, HJ Weinmann, PJ Meier, ... The Journal of pharmacology and experimental therapeutics 290 (1), 153-157, 1999 | 287 | 1999 |
Dephosphorylation of endotoxin by alkaline phosphatase in vivo K Poelstra, WW Bakker, PA Klok, JA Kamps, MJ Hardonk, DK Meijer The American journal of pathology 151 (4), 1163, 1997 | 285 | 1997 |
Removal of phosphate from lipid A as a strategy to detoxify lipopolysaccharide H Bentala, WR Verweij, A Huizinga-Van der Vlag, ... Shock 18 (6), 561-566, 2002 | 276 | 2002 |
Drug uptake systems in liver and kidney JE van Montfoort, B Hagenbuch, GMM Groothuis, H Koepsell, PJ Meier, ... Current drug metabolism 4 (3), 185-211, 2003 | 249 | 2003 |
A physiologic function for alkaline phosphatase: endotoxin detoxification. K Poelstra, WW Bakker, PA Klok, MJ Hardonk, DK Meijer Laboratory investigation; a journal of technical methods and pathology 76 (3 …, 1997 | 244 | 1997 |
LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process MGL Elferink, P Olinga, AL Draaisma, MT Merema, KN Faber, MJH Slooff, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 287 (5 …, 2004 | 230 | 2004 |
Albumin modified with mannose 6–phosphate: a potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells L Beljaars, G Molema, B Weert, H Bonnema, P Olinga, GM Groothuis, ... Hepatology 29 (5), 1486-1493, 1999 | 226 | 1999 |
Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3 V Cattori, JE Montfoort, B Stieger, L Landmann, DK Meijer, ... Pflügers Archiv 443, 188-195, 2001 | 221 | 2001 |
Preparation and Functional Evaluation of RGD-Modified Proteins as αvβ3 Integrin Directed Therapeutics RJ Kok, AJ Schraa, EJ Bos, HE Moorlag, SA Ásgeirsdóttir, M Everts, ... Bioconjugate chemistry 13 (1), 128-135, 2002 | 220 | 2002 |
The effect of parenterally administered cyclodextrins on cholesterol levels in the rat HW Frijlink, AC Eissens, NR Hefting, K Poelstra, CF Lerk, DKF Meijer Pharmaceutical research 8, 9-16, 1991 | 204 | 1991 |
Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor L Beljaars, G Molema, D Schuppan, A Geerts, PJ De Bleser, B Weert, ... Journal of Biological Chemistry 275 (17), 12743-12751, 2000 | 203 | 2000 |
Antiviral Effects of Milk Proteins: Acylation Results in Polyanionic Compounds with Potent Activity against Human Immunodeficiency Virus Types 1 and 2 in Vitro PJ Swart, ME Kuipers, C Smit, R Pauwels, MP De Bethune, E De Clercq, ... AIDS research and human retroviruses 12 (9), 769-775, 1996 | 182 | 1996 |
Specific delivery of captopril to the kidney with the prodrug captopril-lysozyme RJ Kok, F Grijpstra, RB Walthuis, F Moolenaar, D De Zeeuw, DKF Meijer The Journal of pharmacology and experimental therapeutics 288 (1), 281-285, 1999 | 180 | 1999 |