Artykuły udostępnione publicznie: - Nathan BrownWięcej informacji
Niedostępne w żadnym miejscu: 6
Bioisosteric replacement and scaffold hopping in lead generation and optimization
SR Langdon, P Ertl, N Brown
Molecular Informatics 29 (5), 366-385, 2010
Upoważnienia: Cancer Research UK
Structure-based design of imidazo [1, 2-a] pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells
N Bouloc, JM Large, M Kosmopoulou, C Sun, A Faisal, M Matteucci, ...
Bioorganic & medicinal chemistry letters 20 (20), 5988-5993, 2010
Upoważnienia: Cancer Research UK
Algorithms for chemoinformatics
N Brown
Wiley Interdisciplinary Reviews: Computational Molecular Science, 2011
Upoważnienia: Cancer Research UK
Feature Trees
N Brown
Scaffold Hopping in Medicinal Chemistry, 149-154, 2013
Upoważnienia: Cancer Research UK
Three‐Dimensional Scaffold Replacement Methods
N Brown
Scaffold Hopping in Medicinal Chemistry, 175-182, 2013
Upoważnienia: Cancer Research UK
Bioisosteres in De Novo Design
NC Firth, J Blagg, N Brown
De novo Molecular Design, 417-435, 2013
Upoważnienia: Cancer Research UK
Dostępne w jakimś miejscu: 28
Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites
LR Vidler, N Brown, S Knapp, S Hoelder
Journal of medicinal chemistry 55 (17), 7346-7359, 2012
Upoważnienia: Canadian Institutes of Health Research, Genome Canada, Cancer Research UK
Multi-objective optimization methods in drug design
CA Nicolaou, N Brown
Drug Discovery Today: Technologies 10 (3), e427-e435, 2013
Upoważnienia: Cancer Research UK
Fragment-based hit identification: thinking in 3D
AD Morley, A Pugliese, K Birchall, J Bower, P Brennan, N Brown, ...
Drug Discovery Today 18 (23-24), 1221-1227, 2013
Upoważnienia: UK Biotechnology and Biological Sciences Research Council, Cancer Research …
A critical overview of computational approaches employed for COVID-19 drug discovery
EN Muratov, R Amaro, CH Andrade, N Brown, S Ekins, D Fourches, ...
Chemical Society Reviews 50 (16), 9121-9151, 2021
Upoważnienia: US National Science Foundation, Swiss National Science Foundation, US …
Scaffold Diversity of Exemplified Medicinal Chemistry Space
SR Langdon, N Brown, J Blagg
Journal of chemical information and modeling, 2011
Upoważnienia: Cancer Research UK
Discovery of novel small-molecule inhibitors of BRD4 using structure-based virtual screening
LR Vidler, P Filippakopoulos, O Fedorov, S Picaud, S Martin, M Tomsett, ...
Journal of medicinal chemistry 56 (20), 8073-8088, 2013
Upoważnienia: Canadian Institutes of Health Research, Genome Canada, Cancer Research UK …
Plane of best fit: a novel method to characterize the three-dimensionality of molecules
NC Firth, N Brown, J Blagg
Journal of chemical information and modeling 52 (10), 2516-2525, 2012
Upoważnienia: Cancer Research UK
On the origins of three-dimensionality in drug-like molecules
J Meyers, M Carter, NY Mok, N Brown
Future medicinal chemistry 8 (14), 1753-1767, 2016
Upoważnienia: Cancer Research UK, Wellcome Trust
Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript
Z Kote-Jarai, A Amin Al Olama, D Leongamornlert, M Tymrakiewicz, ...
Human genetics, 1-8, 2011
Upoważnienia: Cancer Research UK
Structural basis of poly (ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR)
J Oberoi, MW Richards, S Crumpler, N Brown, J Blagg, R Bayliss
Journal of Biological Chemistry 285 (50), 39348-39358, 2010
Upoważnienia: Cancer Research UK
Bioisosteres and scaffold hopping in medicinal chemistry
N Brown
Molecular informatics 33 (6‐7), 458-462, 2014
Upoważnienia: Cancer Research UK
Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-b]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells
V Bavetsias, A Faisal, S Crumpler, N Brown, M Kosmopoulou, A Joshi, ...
Journal of Medicinal Chemistry 56 (22), 9122-9135, 2013
Upoważnienia: Cancer Research UK
Optimization of Imidazo[4,5-b]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical …
V Bavetsias, S Crumpler, C Sun, S Avery, B Atrash, A Faisal, AS Moore, ...
Journal of medicinal chemistry 55 (20), 8721-8734, 2012
Upoważnienia: Cancer Research UK
MOARF, an integrated workflow for multiobjective optimization: implementation, synthesis, and biological evaluation
NC Firth, B Atrash, N Brown, J Blagg
Journal of chemical information and modeling 55 (6), 1169-1180, 2015
Upoważnienia: Cancer Research UK
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