Obserwuj
ashraf brik
ashraf brik
Professor of Chemistry
Zweryfikowany adres z technion.ac.il - Strona główna
Tytuł
Cytowane przez
Cytowane przez
Rok
HIV-1 protease: mechanism and drug discovery
A Brik, CH Wong
Organic & biomolecular chemistry 1 (1), 5-14, 2003
6822003
Small molecules targeting severe acute respiratory syndrome human coronavirus
CY Wu, JT Jan, SH Ma, CJ Kuo, HF Juan, YSE Cheng, HH Hsu, ...
Proceedings of the National Academy of Sciences 101 (27), 10012-10017, 2004
6462004
1, 2, 3-Triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors
A Brik, J Alexandratos, YC Lin, JH Elder, AJ Olson, A Wlodawer, ...
ChemBioChem 6 (7), 1167-1168, 2005
3862005
Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins
S Bondalapati, M Jbara, A Brik
Nature chemistry 8 (5), 407-418, 2016
3432016
A copper (I)-catalyzed 1, 2, 3-triazole azide− alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant
MJ Giffin, H Heaslet, A Brik, YC Lin, G Cauvi, CH Wong, DE McRee, ...
Journal of medicinal chemistry 51 (20), 6263-6270, 2008
2952008
Highly efficient and chemoselective peptide ubiquitylation
KS Ajish Kumar, M Haj-Yahya, D Olschewski, HA Lashuel, A Brik
Angewandte Chemie (International ed. in English) 48 (43), 8090-4, 2009
2792009
Structural basis for histone H2B deubiquitination by the SAGA DUB module
MT Morgan, M Haj-Yahya, AE Ringel, P Bandi, A Brik, C Wolberger
Science 351 (6274), 725-728, 2016
2672016
Total chemical synthesis of a 304 amino acid K48-linked tetraubiquitin protein
KSA Kumar, SN Bavikar, L Spasser, T Moyal, S Ohayon, A Brik
Angewandte Chemie-International Edition 50 (27), 6137-6141, 2011
2462011
RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation
G Fuchs, E Shema, R Vesterman, E Kotler, Z Wolchinsky, S Wilder, ...
Molecular cell 46 (5), 662-673, 2012
2232012
Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors
A Brik, J Muldoon, YC Lin, JH Elder, DS Goodsell, AJ Olson, VV Fokin, ...
ChemBioChem 4 (11), 1246-1248, 2003
2212003
The size of the proteasomal substrate determines whether its degradation will be mediated by mono-or polyubiquitylation
N Shabek, Y Herman-Bachinsky, S Buchsbaum, O Lewinson, ...
Molecular cell 48 (1), 87-97, 2012
2022012
Total chemical synthesis of di-ubiquitin chains
KSA Kumar, L Spasser, LA Erlich, SN Bavikar, A Brik
Angewandte Chemie-International Edition 49 (48), 9126-9131, 2010
1892010
Protein synthesis assisted by native chemical ligation at leucine
Z Harpaz, P Siman, KSA Kumar, A Brik
ChemBioChem 11 (9), 1232-1235, 2010
1692010
Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology
M Haj-Yahya, B Fauvet, Y Herman-Bachinsky, M Hejjaoui, SN Bavikar, ...
Proceedings of the National Academy of Sciences 110 (44), 17726-17731, 2013
1612013
Efficient palladium‐assisted one‐pot deprotection of (acetamidomethyl) cysteine following native chemical ligation and/or desulfurization to expedite chemical protein synthesis
SK Maity, M Jbara, S Laps, A Brik
Angewandte Chemie 128 (28), 8240-8244, 2016
1562016
Sugar-assisted glycopeptide ligation
A Brik, YY Yang, S Ficht, CH Wong
Journal of the American Chemical Society 128 (17), 5626-5627, 2006
1562006
Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34.
P Siman, SV Karthikeyan, M Nikolov, W Fischle, A Brik
Angewandte Chemie-International Edition 52 (31), 8059-8063, 2013
1462013
Palladium in the chemical synthesis and modification of proteins
M Jbara, SK Maity, A Brik
Angewandte Chemie International Edition 56 (36), 10644-10655, 2017
1452017
Chemistry and biology of the ubiquitin signal
L Spasser, A Brik
Angewandte Chemie International Edition 51 (28), 6840-6862, 2012
1442012
Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein
M Hejjaoui, M Haj-Yahya, K KS, A Brik, HA Lashuel
1442011
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