Artykuły udostępnione publicznie: - Ruth BrenkWięcej informacji
Niedostępne w żadnym miejscu: 2
Probing the dynamic nature of water molecules and their influences on ligand binding in a model binding site
D Cappel, R Wahlström, R Brenk, CA Sotriffer
Journal of chemical information and modeling 51 (10), 2581-2594, 2011
Upoważnienia: German Research Foundation
Ligand design for riboswitches, an emerging target class for novel antibiotics
IH Rekand, R Brenk
Future Medicinal Chemistry 9 (14), 1649-1662, 2017
Upoważnienia: Research Council of Norway
Dostępne w jakimś miejscu: 17
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness
JA Frearson, S Brand, SP McElroy, LAT Cleghorn, O Smid, L Stojanovski, ...
Nature 464 (7289), 728, 2010
Upoważnienia: Canadian Institutes of Health Research, Genome Canada
Novel ligands for a purine riboswitch discovered by RNA-ligand docking
P Daldrop, FE Reyes, DA Robinson, CM Hammond, DM Lilley, RT Batey, ...
Chemistry & biology 18 (3), 324-335, 2011
Upoważnienia: US National Institutes of Health, Cancer Research UK
Riboswitches as Drug Targets for Antibiotics
V Panchal, R Brenk
Antibiotics 10 (1), 45, 2021
Upoważnienia: Research Council of Norway
Crystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation …
B Stengl, EA Meyer, A Heine, R Brenk, F Diederich, G Klebe
Journal of molecular biology 370 (3), 492-511, 2007
Upoważnienia: German Research Foundation
Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma brucei N-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as …
S Brand, NR Norcross, S Thompson, JR Harrison, VC Smith, ...
Journal of medicinal chemistry 57 (23), 9855-9869, 2014
Upoważnienia: UK Medical Research Council, Wellcome Trust
A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors
JR Harrison, S Brand, V Smith, DA Robinson, S Thompson, A Smith, ...
Journal of medicinal chemistry 61 (18), 8374-8389, 2018
Upoważnienia: Wellcome Trust
The small molecule tool (S)-(−)-blebbistatin: novel insights of relevance to myosin inhibitor design
C Lucas-Lopez, JS Allingham, T Lebl, CPAT Lawson, R Brenk, JR Sellers, ...
Organic & biomolecular chemistry 6 (12), 2076-2084, 2008
Upoważnienia: US National Institutes of Health, Canadian Institutes of Health Research
Synthesis, Biological Evaluation, and Crystallographic Studies of Extended Guanine‐Based (lin‐Benzoguanine) Inhibitors for tRNA‐Guanine Transglycosylase (TGT)
EA Meyer, N Donati, M Guillot, WB Schweizer, F Diederich, B Stengl, ...
Helvetica chimica acta 89 (4), 573-597, 2006
Upoważnienia: German Research Foundation
From On‐Target to Off‐Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti‐Trypanosoma brucei Drug …
A Woodland, R Grimaldi, T Luksch, LAT Cleghorn, KK Ojo, ...
ChemMedChem 8 (7), 1127-1137, 2013
Upoważnienia: US National Institutes of Health, Wellcome Trust
The Design and Synthesis of Potent and Selective Inhibitors of Trypanosoma brucei Glycogen Synthase Kinase 3 for the Treatment of Human African Trypanosomiasis
R Urich, R Grimaldi, T Luksch, JA Frearson, R Brenk, PG Wyatt
Journal of medicinal chemistry 57 (18), 7536-7549, 2014
Upoważnienia: Wellcome Trust
Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors
T Bayliss, DA Robinson, VC Smith, S Brand, SP McElroy, LS Torrie, ...
Journal of medicinal chemistry 60 (23), 9790-9806, 2017
Upoważnienia: Wellcome Trust
Development of Small‐Molecule Trypanosoma brucei N‐Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode
D Spinks, V Smith, S Thompson, DA Robinson, T Luksch, A Smith, ...
ChemMedChem 10 (11), 1821-1836, 2015
Upoważnienia: Wellcome Trust
Increasing the Coverage of Medicinal Chemistry-Relevant Space in Commercial Fragments Screening
NY Mok, R Brenk, N Brown
Journal of chemical information and modeling 54 (1), 79-85, 2014
Upoważnienia: Cancer Research UK, Wellcome Trust
How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N-Myristoyltransferases as a Model System
C Kersten, E Fleischer, J Kehrein, C Borek, E Jaenicke, C Sotriffer, ...
Journal of medicinal chemistry 63 (5), 2095-2113, 2019
Upoważnienia: German Research Foundation, Research Council of Norway
Structure-Based Virtual Screening for the Identification of RNA-Binding Ligands
P Daldrop, R Brenk
Therapeutic Applications of Ribozymes and Riboswitches: Methods and …, 2014
Upoważnienia: Wellcome Trust
An experimental toolbox for structure-based hit discovery for P. aeruginosa FabF, a promising target for antibiotics
LO Espeland, C Georgiou, R Klein, H Bhukya, BE Haug, J Underhaug, ...
ChemRxiv, 2021
Upoważnienia: Research Council of Norway
Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a …
B Baum, LSM Lecker, M Zoltner, E Jaenicke, R Schnell, WN Hunter, ...
Acta Crystallographica Section F: Structural Biology Communications 71 (8 …, 2015
Upoważnienia: Wellcome Trust
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