| The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases JM Whitelock, AD Murdoch, RV Iozzo, PA Underwood Journal of Biological Chemistry 271 (17), 10079-10086, 1996 | 805 | 1996 |
| Heparan sulfate: a complex polymer charged with biological activity JM Whitelock, RV Iozzo Chemical reviews 105 (7), 2745-2764, 2005 | 536 | 2005 |
| Diverse cell signaling events modulated by perlecan JM Whitelock, J Melrose, RV Iozzo Biochemistry 47 (43), 11174-11183, 2008 | 330 | 2008 |
| Oxidative damage to extracellular matrix and its role in human pathologies MD Rees, EC Kennett, JM Whitelock, MJ Davies Free Radical Biology and Medicine 44 (12), 1973-2001, 2008 | 289 | 2008 |
| Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo. B Sharma, M Handler, I Eichstetter, JM Whitelock, MA Nugent, RV Iozzo The Journal of clinical investigation 102 (8), 1599-1608, 1998 | 251 | 1998 |
| CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan C Vennin, P Mélénec, R Rouet, M Nobis, AS Cazet, KJ Murphy, ... Nature communications 10 (1), 3637, 2019 | 244 | 2019 |
| Perlecan: how does one molecule do so many things? SM Knox, JM Whitelock Cellular and Molecular Life Sciences CMLS 63, 2435-2445, 2006 | 209 | 2006 |
| Not all perlecans are created equal: interactions with fibroblast growth factor (FGF) 2 and FGF receptors S Knox, C Merry, S Stringer, J Melrose, J Whitelock Journal of Biological Chemistry 277 (17), 14657-14665, 2002 | 202 | 2002 |
| Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis VN Patel, SM Knox, KM Likar, CA Lathrop, R Hossain, S Eftekhari, ... Oxford University Press for The Company of Biologists Limited 134 (23), 4177 …, 2007 | 192 | 2007 |
| The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7 M Mongiat, K Taylor, J Otto, S Aho, J Uitto, JM Whitelock, RV Iozzo Journal of Biological Chemistry 275 (10), 7095-7100, 2000 | 188 | 2000 |
| Cancer metastasis: the role of the extracellular matrix and the heparan sulfate proteoglycan perlecan Z Elgundi, M Papanicolaou, G Major, TR Cox, J Melrose, JM Whitelock, ... Frontiers in oncology 9, 1482, 2020 | 177 | 2020 |
| The modulation of platelet adhesion and activation by chitosan through plasma and extracellular matrix proteins MS Lord, B Cheng, SJ McCarthy, MS Jung, JM Whitelock Biomaterials 32 (28), 6655-6662, 2011 | 169 | 2011 |
| Comparative spatial and temporal localisation of perlecan, aggrecan and type I, II and IV collagen in the ovine meniscus: an ageing study J Melrose, S Smith, M Cake, R Read, J Whitelock Histochemistry and cell biology 124, 225-235, 2005 | 165 | 2005 |
| Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells JM Whitelock, LD Graham, J Melrose, AD Murdoch, RV Iozzo, ... Matrix biology 18 (2), 163-178, 1999 | 163 | 1999 |
| Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis JJ Zoeller, JM Whitelock, RV Iozzo Matrix Biology 28 (5), 284-291, 2009 | 153 | 2009 |
| The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling MS Lord, CY Chuang, J Melrose, MJ Davies, RV Iozzo, JM Whitelock Matrix Biology 35, 112-122, 2014 | 149 | 2014 |
| Structural and functional characterisation of poly (vinyl alcohol) and heparin hydrogels A Nilasaroya, LA Poole-Warren, JM Whitelock, PJ Martens Biomaterials 29 (35), 4658-4664, 2008 | 148 | 2008 |
| A central function for perlecan in skeletal muscle and cardiovascular development JJ Zoeller, A McQuillan, J Whitelock, SY Ho, RV Iozzo Journal of Cell Biology 181 (2), 381-394, 2008 | 142 | 2008 |
| Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan CY Chuang, MS Lord, J Melrose, MD Rees, SM Knox, C Freeman, ... Biochemistry 49 (26), 5524-5532, 2010 | 140 | 2010 |
| The effect of silica nanoparticulate coatings on serum protein adsorption and cellular response MS Lord, BG Cousins, PJ Doherty, JM Whitelock, A Simmons, RL Williams, ... Biomaterials 27 (28), 4856-4862, 2006 | 140 | 2006 |