Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach KS Bankiewicz, JL Eberling, M Kohutnicka, W Jagust, P Pivirotto, ... Experimental neurology 164 (1), 2-14, 2000 | 501 | 2000 |
A review of brain retraction and recommendations for minimizing intraoperative brain injury RJ Andrews, JR Bringas Neurosurgery 33 (6), 1052-1064, 1993 | 381 | 1993 |
Adeno-associated virus serotype 9 transduction in the central nervous system of nonhuman primates L Samaranch, EA Salegio, W San Sebastian, AP Kells, KD Foust, ... Human gene therapy 23 (4), 382-389, 2012 | 357 | 2012 |
Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging R Saito, JR Bringas, TR McKnight, MF Wendland, C Mamot, ... Cancer research 64 (7), 2572-2579, 2004 | 348 | 2004 |
Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC KS Bankiewicz, J Forsayeth, JL Eberling, R Sanchez-Pernaute, P Pivirotto, ... Molecular Therapy 14 (4), 564-570, 2006 | 326 | 2006 |
Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents MT Krauze, R Saito, C Noble, M Tamas, J Bringas, JW Park, MS Berger, ... Journal of neurosurgery 103 (5), 923-929, 2005 | 277 | 2005 |
Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC P Hadaczek, JL Eberling, P Pivirotto, J Bringas, J Forsayeth, ... Molecular Therapy 18 (8), 1458-1461, 2010 | 196 | 2010 |
Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery C Mamot, JB Nguyen, M Pourdehnad, P Hadaczek, R Saito, JR Bringas, ... Journal of neuro-oncology 68, 1-9, 2004 | 190 | 2004 |
Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primates L Samaranch, EA Salegio, W San Sebastian, AP Kells, JR Bringas, ... Human gene therapy 24 (5), 526-532, 2013 | 182 | 2013 |
Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain R Saito, MT Krauze, JR Bringas, C Noble, TR McKnight, P Jackson, ... Experimental neurology 196 (2), 381-389, 2005 | 180 | 2005 |
AAV9-mediated expression of a non-self protein in nonhuman primate central nervous system triggers widespread neuroinflammation driven by antigen-presenting cell transduction L Samaranch, W San Sebastian, AP Kells, EA Salegio, G Heller, ... Molecular Therapy 22 (2), 329-337, 2014 | 167 | 2014 |
Efficient gene therapy-based method for the delivery of therapeutics to primate cortex AP Kells, P Hadaczek, D Yin, J Bringas, V Varenika, J Forsayeth, ... Proceedings of the National Academy of Sciences 106 (7), 2407-2411, 2009 | 165 | 2009 |
Convection-enhanced delivery of tumor necrosis factor-related apoptosis-inducing ligand with systemic administration of temozolomide prolongs survival in an intracranial … R Saito, JR Bringas, A Panner, M Tamas, RO Pieper, MS Berger, ... Cancer research 64 (19), 6858-6862, 2004 | 151 | 2004 |
Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF AP Kells, J Eberling, X Su, P Pivirotto, J Bringas, P Hadaczek, WC Narrow, ... Journal of Neuroscience 30 (28), 9567-9577, 2010 | 148 | 2010 |
Convection-enhanced delivery of adeno-associated virus type 2 (AAV2) into the striatum and transport of AAV2 within monkey brain P Hadaczek, M Kohutnicka, MT Krauze, J Bringas, P Pivirotto, ... Human gene therapy 17 (3), 291-302, 2006 | 142 | 2006 |
Canine spontaneous glioma: a translational model system for convection-enhanced delivery PJ Dickinson, RA LeCouteur, RJ Higgins, JR Bringas, RF Larson, ... Neuro-oncology 12 (9), 928-940, 2010 | 140 | 2010 |
Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys X Su, AP Kells, EJ Huang, HS Lee, P Hadaczek, J Beyer, J Bringas, ... Human gene therapy 20 (12), 1627-1640, 2009 | 124 | 2009 |
Real-time MR imaging of adeno-associated viral vector delivery to the primate brain MS Fiandaca, V Varenika, J Eberling, T McKnight, J Bringas, P Pivirotto, ... Neuroimage 47, T27-T35, 2009 | 122 | 2009 |
A dose-ranging study of AAV-hAADC therapy in Parkinsonian monkeys JR Forsayeth, JL Eberling, LM Sanftner, Z Zhen, P Pivirotto, J Bringas, ... Molecular Therapy 14 (4), 571-577, 2006 | 122 | 2006 |
MR-guided parenchymal delivery of adeno-associated viral vector serotype 5 in non-human primate brain L Samaranch, B Blits, W San Sebastian, P Hadaczek, J Bringas, ... Gene therapy 24 (4), 253-261, 2017 | 120 | 2017 |