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Zachary Sethna
Zachary Sethna
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Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer
LA Rojas, Z Sethna, KC Soares, C Olcese, N Pang, E Patterson, J Lihm, ...
Nature 618 (7963), 144-150, 2023
7022023
ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity
JA Moral, J Leung, LA Rojas, J Ruan, J Zhao, Z Sethna, A Ramnarain, ...
Nature 579 (7797), 130-135, 2020
3202020
Inferring processes underlying B-cell repertoire diversity
Y Elhanati, Z Sethna, Q Marcou, CG Callan Jr, T Mora, AM Walczak
Philosophical Transactions of the Royal Society B: Biological Sciences 370 …, 2015
2272015
OLGA: fast computation of generation probabilities of B-and T-cell receptor amino acid sequences and motifs
Z Sethna, Y Elhanati, CG Callan Jr, AM Walczak, T Mora
Bioinformatics 35 (17), 2974-2981, 2019
2102019
Neoantigen quality predicts immunoediting in survivors of pancreatic cancer
M Łuksza, ZM Sethna, LA Rojas, J Lihm, B Bravi, Y Elhanati, K Soares, ...
Nature 606 (7913), 389-395, 2022
1592022
Predicting the spectrum of TCR repertoire sharing with a data‐driven model of recombination
Y Elhanati, Z Sethna, CG Callan Jr, T Mora, AM Walczak
Immunological reviews 284 (1), 167-179, 2018
1322018
Population variability in the generation and selection of T-cell repertoires
Z Sethna, G Isacchini, T Dupic, T Mora, AM Walczak, Y Elhanati
PLOS Computational Biology 16 (12), e1008394, 2020
602020
Fundamental immune–oncogenicity trade-offs define driver mutation fitness
D Hoyos, R Zappasodi, I Schulze, Z Sethna, KC de Andrade, DF Bajorin, ...
Nature 606 (7912), 172-179, 2022
562022
Insights into immune system development and function from mouse T-cell repertoires
Z Sethna, Y Elhanati, CR Dudgeon, CG Callan Jr, AJ Levine, T Mora, ...
Proceedings of the National Academy of Sciences 114 (9), 2253-2258, 2017
442017
Phase I trial of adjuvant autogene cevumeran, an individualized mRNA neoantigen vaccine, for pancreatic ductal adenocarcinoma.
VP Balachandran, LA Rojas, Z Sethna, K Soares, E Derhovanessian, ...
Journal of Clinical Oncology 40 (16_suppl), 2516-2516, 2022
322022
Accelerating multidimensional NMR and MRI experiments using iterated maps
MA Frey, ZM Sethna, GA Manley, S Sengupta, KW Zilm, JP Loria, ...
Journal of Magnetic Resonance 237, 100-109, 2013
132013
RNA vaccines for cancer: Principles to practice
P Guasp, C Reiche, Z Sethna, VP Balachandran
Cancer Cell, 2024
112024
Generative models of T-cell receptor sequences
G Isacchini, Z Sethna, Y Elhanati, A Nourmohammad, AM Walczak, ...
Physical Review E 101 (6), 062414, 2020
102020
GeneVector: Identification of transcriptional programs using dense vector representations defined by mutual information
N Ceglia, Z Sethna, F Uhlitz, V Bojilova, N Rusk, B Burman, A Chow, ...
bioRxiv, 2022.04. 22.487554, 2022
52022
Identification of transcriptional programs using dense vector representations defined by mutual information with GeneVector
N Ceglia, Z Sethna, SS Freeman, F Uhlitz, V Bojilova, N Rusk, B Burman, ...
Nature Communications 14 (1), 4400, 2023
32023
IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer
M Amisaki, A Zebboudj, H Yano, SL Zhang, G Payne, AK Chandra, R Yu, ...
Nature, 1-9, 2025
22025
Abstract PR-06: Personalized RNA neoantigen vaccines induce long-lived CD8+ T effector cells in pancreatic cancer
P Guasp, Z Sethna, C Reiche, M Milighetti, N Ceglia, E Patterson, N Pang, ...
Cancer Immunology Research 12 (10_Supplement), PR-06-PR-06, 2024
22024
RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer
Z Sethna, P Guasp, C Reiche, M Milighetti, N Ceglia, E Patterson, J Lihm, ...
Nature, 1-10, 2025
12025
TCRi: Information theoretic metrics for single cell RNA and TCR sequencing in cancer
N Ceglia, ZM Sethna, Y Elhanati, B Burman, A Chow, D Zamarin, ...
bioRxiv, 2022.10. 01.510457, 2022
12022
Author Correction: Fundamental immune–oncogenicity trade-offs define driver mutation fitness
D Hoyos, R Zappasodi, I Schulze, Z Sethna, KC de Andrade, DF Bajorin, ...
Nature 606 (7914), E5, 2022
12022
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