| Cyclic peptide drugs approved in the last two decades (2001–2021) H Zhang, S Chen RSC Chemical Biology 3 (1), 18-31, 2022 | 225 | 2022 |
| Bicyclic peptide inhibitor reveals large contact interface with a protease target A Angelini, L Cendron, S Chen, J Touati, G Winter, G Zanotti, C Heinis ACS chemical biology 7 (5), 817-821, 2012 | 212 | 2012 |
| Peptide ligands stabilized by small molecules S Chen, D Bertoldo, A Angelini, F Pojer, C Heinis Angewandte Chemie International Edition 53 (6), 1602-1606, 2014 | 155 | 2014 |
| Structurally diverse cyclisation linkers impose different backbone conformations in bicyclic peptides S Chen, J Morales‐Sanfrutos, A Angelini, B Cutting, C Heinis ChemBioChem 13 (7), 1032-1038, 2012 | 129 | 2012 |
| Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides S Chen, R Gopalakrishnan, T Schaer, F Marger, R Hovius, D Bertrand, ... Nature chemistry 6 (11), 1009-1016, 2014 | 113 | 2014 |
| Bicyclic peptide ligands pulled out of cysteine-rich peptide libraries S Chen, I Rentero Rebollo, SA Buth, J Morales-Sanfrutos, J Touati, ... Journal of the American Chemical Society 135 (17), 6562-6569, 2013 | 111 | 2013 |
| Phage selection of photoswitchable peptide ligands S Bellotto, S Chen, I Rentero Rebollo, HA Wegner, C Heinis Journal of the American Chemical Society 136 (16), 5880-5883, 2014 | 95 | 2014 |
| Identification of highly selective covalent inhibitors by phage display S Chen, S Lovell, S Lee, M Fellner, PD Mace, M Bogyo Nature biotechnology 39 (4), 490-498, 2021 | 92 | 2021 |
| A synthetic factor XIIa inhibitor blocks selectively intrinsic coagulation initiation V Baeriswyl, S Calzavarini, S Chen, A Zorzi, L Bologna, ... ACS chemical biology 10 (8), 1861-1870, 2015 | 90 | 2015 |
| Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases V Baeriswyl, H Rapley, L Pollaro, C Stace, D Teufel, E Walker, S Chen, ... ChemMedChem 7 (7), 1173-1176, 2012 | 87 | 2012 |
| Improving Binding Affinity and Stability of Peptide Ligands by Substituting Glycines with D‐Amino Acids S Chen, D Gfeller, SA Buth, O Michielin, PG Leiman, C Heinis Chembiochem 14 (11), 1316-1322, 2013 | 77 | 2013 |
| Bicyclization and tethering to albumin yields long-acting peptide antagonists A Angelini, J Morales-Sanfrutos, P Diderich, S Chen, C Heinis Journal of medicinal chemistry 55 (22), 10187-10197, 2012 | 64 | 2012 |
| Microwave-assisted efficient copper-promoted N-arylation of amines with arylboronic acids S Chen, H Huang, X Liu, J Shen, H Jiang, H Liu Journal of Combinatorial Chemistry 10 (3), 358-360, 2008 | 53 | 2008 |
| Pattern-based sensing of peptides and aminoglycosides with a single molecular probe B Lee, S Chen, C Heinis, R Scopelliti, K Severin Organic letters 15 (13), 3456-3459, 2013 | 25 | 2013 |
| Synthetic and biological approaches to map substrate specificities of proteases S Chen, JJ Yim, M Bogyo Biological chemistry 401 (1), 165-182, 2019 | 20 | 2019 |
| Phage selection of bicyclic peptides based on two disulfide bridges S Chen, C Heinis Peptide Libraries: Methods and Protocols, 119-137, 2014 | 20 | 2014 |
| Tracking chemical reactions on the surface of filamentous phage using mass spectrometry S Chen, J Touati, C Heinis Chemical Communications 50 (40), 5267-5269, 2014 | 16 | 2014 |
| Phage selection of mono-and bicyclic peptide ligands S Chen, C Heinis | 5 | 2013 |
| Screening macrocyclic peptide libraries by yeast display allows control of selection process and affinity ranking S Linciano, Y Mazzocato, Z Romanyuk, F Vascon, LF Soler, E Will, Y Xing, ... bioRxiv, 2024.08. 24.609237, 2024 | 1 | 2024 |
| DNA encoded peptide library for SARS-CoV-2 3CL protease covalent inhibitor discovery and profiling Y Xing, H Zhang, Y Wang, Z Zong, M Bogyo, S Chen RSC Chemical Biology 5 (7), 691-702, 2024 | 1 | 2024 |
Christian HeinisProfessor, EPFLVerifisert e-postadresse på epfl.ch
