Alejandro Chavez

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George ChurchHarvard Medical SchoolVerifisert e-postadresse på harvard.edu
James J CollinsMIT; Wyss Institute, Harvard; Broad Institute of MIT & HarvardVerifisert e-postadresse på mit.edu
Benjamin W Pruitt10x GenomicsVerifisert e-postadresse på 10xgenomics.com
Xiaoge GuoNabla Bio / Wyss Institute at Harvard / Harvard Medical SchoolVerifisert e-postadresse på wyss.harvard.edu
Samira KianiSchool of Biological and Health Systems Engineering-Arizona State UniversityVerifisert e-postadresse på asu.edu
Rebecca S ShapiroAssociate Professor, University of GuelphVerifisert e-postadresse på uoguelph.ca
F. Brad Johnson, MD, PhDProfessor of Pathology and Laboratory MedicineVerifisert e-postadresse på pennmedicine.upenn.edu
David Hoprofessor of medicine, Columbia universityVerifisert e-postadresse på cumc.columbia.edu
Sho IketaniColumbia University Medical CenterVerifisert e-postadresse på cumc.columbia.edu
James E. DiCarloVertex PharmaceuticalsVerifisert e-postadresse på vrtx.com
Raj ChariLeidos Biomedical Research, Frederick National Lab for Cancer ResearchVerifisert e-postadresse på nih.gov
Ron WeissProfessor of Biological Engineering, Massachusetts Institute of TechnologyVerifisert e-postadresse på mit.edu
Mo EbrahimkhaniAssociate professor, Department of Pathology, University of PittsburghVerifisert e-postadresse på pitt.edu
Kevin EsveltAssociate Professor, MIT Media LabVerifisert e-postadresse på mit.edu
Stephen P. GoffProfessor of Biochemistry and Molecular Biophysics, Columbia UniversityVerifisert e-postadresse på cumc.columbia.edu
Bruce CulbertsonMD/PhD candidate, Columbia UniversityVerifisert e-postadresse på cumc.columbia.edu
Yosef SaboDepartment of Medicine / ADARC, Columbia UniversityVerifisert e-postadresse på cumc.columbia.edu
Avinash BhandoolaLGI, NCI, NIHVerifisert e-postadresse på nih.gov
Richard I. MorimotoBill and Gayle Cook Professor of Biology, Dept of Molecular Biosciences, NorthwesternVerifisert e-postadresse på northwestern.edu
Ronald PlasterkVerifisert e-postadresse på tiscali.nl

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Alejandro Chavez

Associate Professor - University of California San Diego

Verifisert e-postadresse på health.ucsd.edu - Startside

Synthetic biology Genome engineering High-throughput Screening Neurodegenerative Disease


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Age-related clonal hematopoiesis associated with adverse outcomes S Jaiswal, P Fontanillas, J Flannick, A Manning, PV Grauman, BG Mar, ... New England Journal of Medicine 371 (26), 2488-2498, 2014	4634	2014
Highly efficient Cas9-mediated transcriptional programming A Chavez, J Scheiman, S Vora, BW Pruitt, M Tuttle, E PR Iyer, S Lin, ... Nature methods 12 (4), 326-328, 2015	1689	2015
Comparison of Cas9 activators in multiple species A Chavez, M Tuttle, BW Pruitt, B Ewen-Campen, R Chari, ... Nature methods 13 (7), 563-567, 2016	591	2016
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation EAA Nollen, SM Garcia, G Van Haaften, S Kim, A Chavez, RI Morimoto, ... Proceedings of the National Academy of Sciences of the United States of …, 2004	516	2004
Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform JM Rock, FF Hopkins, A Chavez, M Diallo, MR Chase, ER Gerrick, ... Nature microbiology 2 (4), 1-9, 2017	491	2017
An enhanced CRISPR repressor for targeted mammalian gene regulation NC Yeo, A Chavez, A Lance-Byrne, Y Chan, D Menn, D Milanova, ... Nature methods 15 (8), 611-616, 2018	485	2018
A critical role for TCF-1 in T-lineage specification and differentiation BN Weber, AWS Chi, A Chavez, Y Yashiro-Ohtani, Q Yang, O Shestova, ... Nature 476 (7358), 63-68, 2011	459	2011
Safeguarding CRISPR-Cas9 gene drives in yeast JE DiCarlo, A Chavez, SL Dietz, KM Esvelt, GM Church Nature biotechnology 33 (12), 1250-1255, 2015	399	2015
Cas9 gRNA engineering for genome editing, activation and repression S Kiani, A Chavez, M Tuttle, RN Hall, R Chari, D Ter-Ovanesyan, J Qian, ... Nature methods 12 (11), 1051-1054, 2015	371	2015
An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance AC Bester, JD Lee, A Chavez, YR Lee, D Nachmani, S Vora, J Victor, ... Cell 173 (3), 649-664. e20, 2018	303	2018
Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir S Iketani, H Mohri, B Culbertson, SJ Hong, Y Duan, MI Luck, ... Nature 613 (7944), 558-564, 2023	276	2023
Daisy-chain gene drives for the alteration of local populations C Noble, J Min, J Olejarz, J Buchthal, A Chavez, AL Smidler, ... Proceedings of the National Academy of Sciences 116 (17), 8275-8282, 2019	249	2019
sgRNA Scorer 2.0: A species-independent model to predict CRISPR/Cas9 activity R Chari, NC Yeo, A Chavez, GM Church ACS synthetic biology 6 (5), 902-904, 2017	232	2017
Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks R Clarke, R Heler, MS MacDougall, NC Yeo, A Chavez, M Regan, ... Molecular cell 71 (1), 42-55. e8, 2018	157	2018
A CRISPR–Cas9-based gene drive platform for genetic interaction analysis in Candida albicans RS Shapiro, A Chavez, CBM Porter, M Hamblin, CS Kaas, JE DiCarlo, ... Nature microbiology 3 (1), 73-82, 2018	155	2018
Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors S Iketani, F Forouhar, H Liu, SJ Hong, FY Lin, MS Nair, A Zask, Y Huang, ... Nature communications 12 (1), 2016, 2021	111	2021
CRISPR-based genomic tools for the manipulation of genetically intractable microorganisms RS Shapiro, A Chavez, JJ Collins Nature Reviews Microbiology 16 (6), 333-339, 2018	103	2018
High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR–Cas9 in yeast X Guo, A Chavez, A Tung, Y Chan, C Kaas, Y Yin, R Cecchi, SL Garnier, ... Nature biotechnology 36 (6), 540-546, 2018	98	2018
Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence JM Platt, P Ryvkin, JJ Wanat, G Donahue, MD Ricketts, SP Barrett, ... Genes & development 27 (12), 1406-1420, 2013	98	2013
Mutant Cas9 proteins A Chavez, F Poelwijk, GM Church US Patent 9,074,199, 2015	79	2015

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