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Steven G. Younkin
Steven G. Younkin
Professor of Neuroscience, Mayo Clinic
Verifisert e-postadresse på mayo.edu
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Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
K Hsiao, P Chapman, S Nilsen, C Eckman, Y Harigaya, S Younkin, ...
Science 274 (5284), 99-103, 1996
55111996
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
JC Lambert, CA Ibrahim-Verbaas, D Harold, AC Naj, R Sims, ...
Nature genetics 45 (12), 1452-1458, 2013
47472013
Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to …
D Scheuner, C Eckman, M Jensen, X Song, M Citron, N Suzuki, TD Bird, ...
Nature medicine 2 (8), 864-870, 1996
36671996
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
D Harold, R Abraham, P Hollingworth, R Sims, A Gerrish, ML Hamshere, ...
Nature genetics 41 (10), 1088-1093, 2009
34552009
TREM2 Variants in Alzheimer's Disease
R Guerreiro, A Wojtas, J Bras, M Carrasquillo, E Rogaeva, E Majounie, ...
New England Journal of Medicine 368 (2), 117-127, 2013
33502013
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ...
Nature genetics 51 (3), 414-430, 2019
26752019
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
P Hollingworth, D Harold, R Sims, A Gerrish, JC Lambert, ...
Nature genetics 43 (5), 429-435, 2011
23222011
An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp717) Mutants
N Suzuki, TT Cheung, XD Cai, A Odaka, L Otvos Jr, C Eckman, TE Golde, ...
Science 264 (5163), 1336-1340, 1994
22711994
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
AC Naj, G Jun, GW Beecham, LS Wang, BN Vardarajan, J Buros, ...
Nature genetics 43 (5), 436-441, 2011
22592011
Familial Alzheimer's disease–linked presenilin 1 variants elevate Aβ1–42/1–40 ratio in vitro and in vivo
DR Borchelt, G Thinakaran, CB Eckman, MK Lee, F Davenport, ...
Neuron 17 (5), 1005-1013, 1996
21281996
Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1
K Duff, C Eckman, C Zehr, X Yu, CM Prada, J Perez-Tur, M Hutton, L Buee, ...
Nature 383 (6602), 710-713, 1996
20911996
Production of the Alzheimer amyloid β protein by normal proteolytic processing
M Shoji, TE Golde, J Ghiso, TT Cheung, S Estus, LM Shaffer, XD Cai, ...
Science 258 (5079), 126-129, 1992
19881992
Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase
JL Jankowsky, DJ Fadale, J Anderson, GM Xu, V Gonzales, NA Jenkins, ...
Human molecular genetics 13 (2), 159-170, 2004
18422004
The'Arctic'APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation
C Nilsberth, A Westlind-Danielsson, CB Eckman, MM Condron, ...
Nature neuroscience 4 (9), 887-893, 2001
15892001
Genome-wide analysis of genetic loci associated with Alzheimer disease
S Seshadri, AL Fitzpatrick, MA Ikram, AL DeStefano, V Gudnason, ...
Jama 303 (18), 1832-1840, 2010
15132010
Release of excess amyloid β protein from a mutant amyloid β protein precursor
XD Cai, TE Golde, SG Younkin
Science 259 (5094), 514-516, 1993
14881993
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
E Rogaeva, Y Meng, JH Lee, Y Gu, T Kawarai, F Zou, T Katayama, ...
Nature genetics 39 (2), 168-177, 2007
14532007
Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease
T Kawarabayashi, LH Younkin, TC Saido, M Shoji, KH Ashe, SG Younkin
Journal of neuroscience 21 (2), 372-381, 2001
12952001
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
PF Chapman, GL White, MW Jones, D Cooper-Blacketer, VJ Marshall, ...
Nature neuroscience 2 (3), 271-276, 1999
12041999
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
R Sims, SJ Van Der Lee, AC Naj, C Bellenguez, N Badarinarayan, ...
Nature genetics 49 (9), 1373-1384, 2017
10122017
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