Artikler med mandater om offentlig tilgang - Phil HewittLes mer
Tilgjengelige et eller annet sted: 17
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating …
P Godoy, NJ Hewitt, U Albrecht, ME Andersen, N Ansari, S Bhattacharya, ...
Archives of toxicology 87, 1315-1530, 2013
Mandater: Swiss National Science Foundation, US National Institutes of Health …
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
RJ Weaver, EA Blomme, AE Chadwick, IM Copple, HHJ Gerets, ...
Nature Reviews Drug Discovery 19 (2), 131-148, 2020
Mandater: UK Medical Research Council, Federal Ministry of Education and Research, Germany
Human-induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient-dependent efficiency
D Hallam, G Hilgen, B Dorgau, L Zhu, M Yu, S Bojic, P Hewitt, M Schmitt, ...
Stem cells 36 (10), 1535-1551, 2018
Mandater: UK Medical Research Council, National Centre for the Replacement, Refinement …
Performance of novel kidney biomarkers in preclinical toxicity studies
D Hoffmann, M Adler, VS Vaidya, E Rached, L Mulrane, WM Gallagher, ...
Toxicological Sciences 116 (1), 8-22, 2010
Mandater: US National Institutes of Health
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
RL Sison-Young, VM Lauschke, E Johann, E Alexandre, S Antherieu, ...
Archives of toxicology 91, 1385-1400, 2017
Mandater: European Commission
Comparative proteomic characterization of 4 human liver-derived single cell culture models reveals significant variation in the capacity for drug disposition, bioactivation …
RLC Sison-Young, D Mitsa, RE Jenkins, D Mottram, E Alexandre, ...
Toxicological Sciences 147 (2), 412-424, 2015
Mandater: UK Medical Research Council, European Commission
Delineation of the key aspects in the regulation of epithelial monolayer formation
L Aschauer, LN Gruber, W Pfaller, A Limonciel, TJ Athersuch, R Cavill, ...
Molecular and cellular biology 33 (13), 2535-2550, 2013
Mandater: UK Medical Research Council
Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data
A Krebs, T Waldmann, MF Wilks, BMA van Vugt-Lussenburg, ...
ALTEX-Alternatives to animal experimentation 36 (4), 682-699, 2019
Mandater: European Commission, Federal Ministry of Education and Research, Germany
Optimizing drug discovery by investigative toxicology: current and future trends
M Beilmann, H Boonen, A Czich, G Dear, P Hewitt, T Mow, P Newham, ...
ALTEX-Alternatives to animal experimentation 36 (2), 289-313, 2019
Mandater: European Commission
Microphysiological systems evaluation: experience of TEX-VAL tissue chip testing consortium
I Rusyn, C Sakolish, Y Kato, C Stephan, L Vergara, P Hewitt, V Bhaskaran, ...
Toxicological Sciences 188 (2), 143-152, 2022
Mandater: US National Institutes of Health
Human retinal organoids provide a suitable tool for toxicological investigations: a comprehensive validation using drugs and compounds affecting the retina
B Dorgau, M Georgiou, A Chaudhary, M Moya-Molina, J Collin, R Queen, ...
Stem Cells Translational Medicine 11 (2), 159-177, 2022
Mandater: US National Institutes of Health, UK Biotechnology and Biological Sciences …
Incorporating microglia‐like cells in human induced pluripotent stem cell‐derived retinal organoids
V Chichagova, M Georgiou, M Carter, B Dorgau, G Hilgen, J Collin, ...
Journal of cellular and molecular medicine 27 (3), 435-445, 2023
Mandater: Canadian Institutes of Health Research, UK Biotechnology and Biological …
Analysis of reproducibility and robustness of OrganoPlate® 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs
Y Kato, AY Lim, C Sakolish, A Valdiviezo, HL Moyer, P Hewitt, P Bajaj, ...
Toxicology in Vitro 85, 105464, 2022
Mandater: US National Institutes of Health
IL-2-mediated hepatotoxicity: knowledge gap identification based on the irAOP concept
LA Roser, C Sakellariou, M Lindstedt, V Neuhaus, S Dehmel, C Sommer, ...
Journal of immunotoxicology 21 (sup1), S60-S78, 2024
Mandater: Fraunhofer-Gesellschaft, European Commission, Juvenile Diabetes Research …
Immuno-inflammatory in vitro hepatotoxicity models to assess side effects of biologicals exemplified by aldesleukin
LA Roser, S Luckhardt, N Ziegler, D Thomas, PV Wagner, G Damm, ...
Frontiers in Immunology 14, 1275368, 2023
Mandater: Fraunhofer-Gesellschaft, European Commission, Juvenile Diabetes Research …
Reproducibility and robustness of a liver microphysiological system PhysioMimix LC12 under varying culture conditions and cell type combinations
AY Lim, Y Kato, C Sakolish, A Valdiviezo, G Han, P Bajaj, J Stanko, ...
Bioengineering 10 (10), 1195, 2023
Mandater: US National Institutes of Health
A rat toxicogenomics study with the calcium sensitizer EMD82571 reveals a pleiotropic cause of teratogenicity
PG Hewitt, PK Singh, A Kumar, C Gnewuch, G Liebisch, G Schmitz, ...
Reproductive Toxicology 47, 89-101, 2014
Mandater: Fraunhofer-Gesellschaft
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