| De novo assembly of the goldfish (Carassius auratus) genome and the evolution of genes after whole-genome duplication Z Chen, Y Omori, S Koren, T Shirokiya, T Kuroda, A Miyamoto, H Wada, ... Science advances 5 (6), eaav0547, 2019 | 212 | 2019 |
| Folates and one-carbon metabolism in plants and fungi EA Cossins, L Chen Phytochemistry 45 (3), 437-452, 1997 | 197 | 1997 |
| Cyanide trapping of iminium ion reactive intermediates followed by detection and structure identification using liquid chromatography− tandem mass spectrometry (LC-MS/MS) D Argoti, L Liang, A Conteh, L Chen, D Bershas, CP Yu, P Vouros, E Yang Chemical research in toxicology 18 (10), 1537-1544, 2005 | 180 | 2005 |
| Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for> 200 compounds MZ Sakatis, MJ Reese, AW Harrell, MA Taylor, IA Baines, L Chen, ... Chemical Research in Toxicology 25 (10), 2067-2082, 2012 | 125 | 2012 |
| Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data HJ Einolf, L Chen, OA Fahmi, CR Gibson, RS Obach, M Shebley, J Silva, ... Clinical Pharmacology & Therapeutics 95 (2), 179-188, 2014 | 94 | 2014 |
| Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter … ME Taub, K Mease, RS Sane, CA Watson, L Chen, H Ellens, B Hirakawa, ... Drug metabolism and disposition 39 (11), 2093-2102, 2011 | 83 | 2011 |
| Distribution of folate derivatives and enzymes for synthesis of 10-formyltetrahydrofolate in cytosolic and mitochondrial fractions of pea leaves L Chen, SY Chan, EA Cossins Plant physiology 115 (1), 299-309, 1997 | 74 | 1997 |
| Considerations from the innovation and quality induction working group in response to drug-drug interaction guidances from regulatory agencies: focus on CYP3A4 mRNA in vitro … JR Kenny, D Ramsden, DB Buckley, S Dallas, C Fung, M Mohutsky, ... Drug Metabolism and Disposition 46 (9), 1285-1303, 2018 | 53 | 2018 |
| Inhibition of intestinal OATP2B1 by the calcium receptor antagonist ronacaleret results in a significant drug-drug interaction by causing a 2-fold decrease in exposure of … M Johnson, D Patel, C Matheny, M Ho, L Chen, H Ellens Drug Metabolism and Disposition 45 (1), 27-34, 2017 | 45 | 2017 |
| Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins L Salphati, X Chu, L Chen, B Prasad, S Dallas, R Evers, ... Drug Metabolism and Disposition 42 (8), 1301-1313, 2014 | 45 | 2014 |
| Evaluation of CYP2B6 induction and prediction of clinical drug–drug interactions: considerations from the IQ consortium induction working group—an industry perspective OA Fahmi, M Shebley, J Palamanda, MW Sinz, D Ramsden, HJ Einolf, ... Drug Metabolism and Disposition 44 (10), 1720-1730, 2016 | 44 | 2016 |
| Considerations from the IQ induction working group in response to drug-drug interaction guidance from regulatory agencies: focus on downregulation, CYP2C induction, and CYP2B6 … N Hariparsad, D Ramsden, J Palamanda, JG Dekeyser, OA Fahmi, ... Drug Metabolism and Disposition 45 (10), 1049-1059, 2017 | 41 | 2017 |
| Carcinogenicity assessment of daprodustat (GSK1278863), a hypoxia-inducible factor (HIF)-prolyl hydroxylase inhibitor DF Adams, MS Watkins, L Durette, J Laliberte, F Goulet, E Debien, ... Toxicologic Pathology 48 (2), 362-378, 2020 | 36 | 2020 |
| An integrated reactive metabolite evaluation approach to assess and reduce safety risk during drug discovery and development M Reese, M Sakatis, J Ambroso, A Harrell, E Yang, L Chen, M Taylor, ... Chemico-biological interactions 192 (1-2), 60-64, 2011 | 34 | 2011 |
| A 5, 10-methylenetetrahydrofolate dehydrogenase: 5, 10-methenyltetrahydrofolate cyclohydrolase protein from Pisum sativum CD Kirk, L Chen, HC Imeson, EA Cossins Phytochemistry 39 (6), 1309-1317, 1995 | 31 | 1995 |
| Generation and characterization of a breast cancer resistance protein humanized mouse model S Dallas, L Salphati, D Gomez-Zepeda, T Wanek, L Chen, X Chu, J Kunta, ... Molecular Pharmacology 89 (5), 492-504, 2016 | 25 | 2016 |
| Temporal kinetics and concentration–response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes RA Graham, LO Tyler, WL Krol, IS Silver, LO Webster, P Clark, L Chen, ... Journal of Biochemical and Molecular Toxicology 20 (2), 69-78, 2006 | 25 | 2006 |
| Prediction of the transporter-mediated drug-drug interaction potential of dabrafenib and its major circulating metabolites H Ellens, M Johnson, SK Lawrence, C Watson, L Chen, ... Drug Metabolism and Disposition 45 (6), 646-656, 2017 | 22 | 2017 |
| Considerations from the Innovation and Quality Induction Working Group in response to drug-drug interaction guidance from regulatory agencies: guidelines on model fitting and … SG Wong, D Ramsden, S Dallas, C Fung, HJ Einolf, J Palamanda, L Chen, ... Drug Metabolism and Disposition 49 (1), 94-110, 2021 | 21 | 2021 |
| A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation W Pei, L Xu, Z Chen, CC Slevin, KP Pettie, S Wincovitch, SM Burgess NPJ Regenerative medicine 5 (1), 6, 2020 | 16 | 2020 |
