| Synthetic amyloid-β oligomers impair long-term memory independently of cellular prion protein C Balducci, M Beeg, M Stravalaci, A Bastone, A Sclip, E Biasini, L Tapella, ... Proceedings of the National Academy of Sciences 107 (5), 2295-2300, 2010 | 613 | 2010 |
| Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation B Drisaldi, RS Stewart, C Adles, LR Stewart, E Quaglio, E Biasini, L Fioriti, ... Journal of Biological Chemistry 278 (24), 21732-21743, 2003 | 287 | 2003 |
| An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo BR Fluharty, E Biasini, M Stravalaci, A Sclip, L Diomede, C Balducci, ... Journal of Biological Chemistry 288 (11), 7857-7866, 2013 | 221 | 2013 |
| Prion protein at the crossroads of physiology and disease E Biasini, JA Turnbaugh, U Unterberger, DA Harris Trends in neurosciences 35 (2), 92-103, 2012 | 202 | 2012 |
| Full atomistic model of prion structure and conversion G Spagnolli, M Rigoli, S Orioli, AM Sevillano, P Faccioli, H Wille, E Biasini, ... PLoS pathogens 15 (7), e1007864, 2019 | 131 | 2019 |
| Proteasome inhibition and aggregation in Parkinson's disease: a comparative study in untransfected and transfected cells E Biasini, L Fioriti, I Ceglia, R Invernizzi, A Bertoli, R Chiesa, G Forloni Journal of neurochemistry 88 (3), 545-553, 2004 | 93 | 2004 |
| The N-terminal, polybasic region of PrPC dictates the efficiency of prion propagation by binding to PrPSc JA Turnbaugh, U Unterberger, P Saá, T Massignan, BR Fluharty, ... Journal of Neuroscience 32 (26), 8817-8830, 2012 | 90 | 2012 |
| Regulation of HuR structure and function by dihydrotanshinone-I P Lal, L Cerofolini, VG D’Agostino, C Zucal, C Fuccio, I Bonomo, E Dassi, ... Nucleic acids research 45 (16), 9514-9527, 2017 | 87 | 2017 |
| Proteomic analysis of spinal cord of presymptomatic amyotrophic lateral sclerosis G93A SOD1 mouse T Massignan, F Casoni, M Basso, P Stefanazzi, E Biasini, M Tortarolo, ... Biochemical and biophysical research communications 353 (3), 719-725, 2007 | 86 | 2007 |
| An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity IH Solomon, N Khatri, E Biasini, T Massignan, JE Huettner, DA Harris Journal of Biological Chemistry 286 (16), 14724-14736, 2011 | 84 | 2011 |
| Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans S Yin, N Pham, S Yu, C Li, P Wong, B Chang, SC Kang, E Biasini, P Tien, ... Proceedings of the National Academy of Sciences 104 (18), 7546-7551, 2007 | 77 | 2007 |
| Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities R Chiesa, P Piccardo, E Biasini, B Ghetti, DA Harris Journal of Neuroscience 28 (49), 13258-13267, 2008 | 70 | 2008 |
| Redox regulation of cyclophilin A by glutathionylation P Ghezzi, S Casagrande, T Massignan, M Basso, E Bellacchio, L Mollica, ... Proteomics 6 (3), 817-825, 2006 | 61 | 2006 |
| Interfering with HuR–RNA interaction: design, synthesis and biological characterization of tanshinone mimics as novel, effective HuR inhibitors L Manzoni, C Zucal, DD Maio, VG D’Agostino, N Thongon, I Bonomo, ... Journal of Medicinal Chemistry 61 (4), 1483-1498, 2018 | 59 | 2018 |
| Non‐infectious aggregates of the prion protein react with several PrPSc‐directed antibodies E Biasini, ME Seegulam, BN Patti, L Solforosi, AZ Medrano, ... Journal of neurochemistry 105 (6), 2190-2204, 2008 | 58 | 2008 |
| A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity E Biasini, U Unterberger, IH Solomon, T Massignan, A Senatore, H Bian, ... Journal of Neuroscience 33 (6), 2408-2418, 2013 | 55 | 2013 |
| Pharmacological agents targeting the cellular prion protein ML Barreca, N Iraci, S Biggi, V Cecchetti, E Biasini Pathogens 7 (1), 27, 2018 | 54 | 2018 |
| Pharmacological inactivation of the prion protein by targeting a folding intermediate G Spagnolli, T Massignan, A Astolfi, S Biggi, M Rigoli, P Brunelli, ... Communications Biology 4 (1), 62, 2021 | 53 | 2021 |
| The N-terminal, polybasic region is critical for prion protein neuroprotective activity JA Turnbaugh, L Westergard, U Unterberger, E Biasini, DA Harris PloS one 6 (9), e25675, 2011 | 51 | 2011 |
| Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor α (GDI)/Rab11 pathway T Massignan, E Biasini, E Lauranzano, P Veglianese, M Pignataro, ... Molecular & Cellular Proteomics 9 (4), 611-622, 2010 | 48 | 2010 |
Roberto ChiesaLaboratory of Prion Neurobiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, MilanVerifisert e-postadresse på marionegri.it
Tania MassignanSibylla Biotech srlVerifisert e-postadresse på sibyllabiotech.itMatteo StravalaciFondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoVerifisert e-postadresse på policlinico.mi.it
Marco GobbiIstituto di Ricerche Farmacologiche Mario Negri IRCCSVerifisert e-postadresse på marionegri.it
Valentina BonettoCoordinator of the Research Center for ALS, Head of the Laboratory of Translational BiomarkersVerifisert e-postadresse på marionegri.it
Maria Letizia BarrecaDepartment of Pharmaceutical Sciences - University of PerugiaVerifisert e-postadresse på unipg.it
Manuela BassoCentre for Integrative Biology, CIBIO, Trento
