Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021 | 13694* | 2021 |
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor Z Yue, S Jin, C Yang, AJ Levine, N Heintz Proceedings of the National Academy of Sciences 100 (25), 15077-15082, 2003 | 2664 | 2003 |
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice M Komatsu, S Waguri, M Koike, Y Sou, T Ueno, T Hara, N Mizushima, ... Cell 131 (6), 1149-1163, 2007 | 2443 | 2007 |
Molecular definitions of autophagy and related processes L Galluzzi, EH Baehrecke, A Ballabio, P Boya, JM Bravo‐San Pedro, ... The EMBO journal 36 (13), 1811-1836, 2017 | 1727 | 2017 |
Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits G Tang, K Gudsnuk, SH Kuo, ML Cotrina, G Rosoklija, A Sosunov, ... Neuron 83 (5), 1131-1143, 2014 | 1283 | 2014 |
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex Y Zhong, QJ Wang, X Li, Y Yan, JM Backer, BT Chait, N Heintz, Z Yue Nature cell biology 11 (4), 468-476, 2009 | 1154 | 2009 |
Autophagy in major human diseases DJ Klionsky, G Petroni, RK Amaravadi, EH Baehrecke, A Ballabio, P Boya, ... The EMBO journal 40 (19), e108863, 2021 | 1153 | 2021 |
The Beclin 1–VPS34 complex–at the crossroads of autophagy and beyond SF Funderburk, QJ Wang, Z Yue Trends in cell biology 20 (6), 355-362, 2010 | 944 | 2010 |
Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues V Hernández–Gea, Z Ghiassi–Nejad, R Rozenfeld, R Gordon, MI Fiel, ... Gastroenterology 142 (4), 938-946, 2012 | 718 | 2012 |
Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration M Komatsu, QJ Wang, GR Holstein, VL Friedrich Jr, J Iwata, E Kominami, ... Proceedings of the National Academy of Sciences 104 (36), 14489-14494, 2007 | 694 | 2007 |
Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience AK Friedman, JJ Walsh, B Juarez, SM Ku, D Chaudhury, J Wang, X Li, ... Science 344 (6181), 313-319, 2014 | 540 | 2014 |
Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration I Choi, Y Zhang, SP Seegobin, M Pruvost, Q Wang, K Purtell, B Zhang, ... Nature communications 11 (1), 1386, 2020 | 444 | 2020 |
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations Z Sheng, S Zhang, D Bustos, T Kleinheinz, CE Le Pichon, SL Dominguez, ... Science translational medicine 4 (164), 164ra161-164ra161, 2012 | 418 | 2012 |
Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S X Li, JC Patel, J Wang, MV Avshalumov, C Nicholson, JD Buxbaum, ... Journal of Neuroscience 30 (5), 1788-1797, 2010 | 413 | 2010 |
Autophagy in ischemic stroke P Wang, BZ Shao, Z Deng, S Chen, Z Yue, CY Miao Progress in neurobiology 163, 98-117, 2018 | 400 | 2018 |
Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease KY Hui, H Fernandez-Hernandez, J Hu, A Schaffner, N Pankratz, NY Hsu, ... Science translational medicine 10 (423), eaai7795, 2018 | 398 | 2018 |
Induction of autophagy in axonal dystrophy and degeneration QJ Wang, Y Ding, S Kohtz, N Mizushima, IM Cristea, MP Rout, BT Chait, ... Journal of Neuroscience 26 (31), 8057-8068, 2006 | 392 | 2006 |
The Sac1 Domain of SYNJ1 Identified Mutated in a Family with Early‐Onset Progressive Parkinsonism with Generalized Seizures CE Krebs, S Karkheiran, JC Powell, M Cao, V Makarov, H Darvish, ... Human mutation 34 (9), 1200-1207, 2013 | 386 | 2013 |
A novel protein complex linking the δ2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice Z Yue, A Horton, M Bravin, PL DeJager, F Selimi, N Heintz Neuron 35 (5), 921-933, 2002 | 381 | 2002 |
Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates J Lim, ML Lachenmayer, S Wu, W Liu, M Kundu, R Wang, M Komatsu, ... PLoS genetics 11 (2), e1004987, 2015 | 343 | 2015 |