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| Development of human protein reference database as an initial platform for approaching systems biology in humans S Peri, JD Navarro, R Amanchy, TZ Kristiansen, CK Jonnalagadda, ... Genome research 13 (10), 2363-2371, 2003 | 1356 | 2003 |
| JAK/STAT signaling in hematological malignancies W Vainchenker, SN Constantinescu Oncogene 32 (21), 2601-2613, 2013 | 637 | 2013 |
| Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line: pathways that are shared with and distinct from IL-10 D Lejeune, L Dumoutier, S Constantinescu, W Kruijer, JJ Schuringa, ... Journal of Biological Chemistry 277 (37), 33676-33682, 2002 | 602 | 2002 |
| Autoantibodies neutralizing type I IFNs are present in~ 4% of uninfected individuals over 70 years old and account for~ 20% of COVID-19 deaths P Bastard, A Gervais, T Le Voyer, J Rosain, Q Philippot, J Manry, ... Science immunology 6 (62), eabl4340, 2021 | 544 | 2021 |
| New mutations and pathogenesis of myeloproliferative neoplasms W Vainchenker, F Delhommeau, SN Constantinescu, OA Bernard Blood, The Journal of the American Society of Hematology 118 (7), 1723-1735, 2011 | 544 | 2011 |
| NetPath: a public resource of curated signal transduction pathways K Kandasamy, SS Mohan, R Raju, S Keerthikumar, GSS Kumar, ... Genome biology 11, 1-9, 2010 | 540 | 2010 |
| Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia E Flex, V Petrangeli, L Stella, S Chiaretti, T Hornakova, L Knoops, ... Journal of Experimental Medicine 205 (4), 751-758, 2008 | 459 | 2008 |
| Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells X Liu, Y Sun, SN Constantinescu, E Karam, RA Weinberg, HF Lodish Proceedings of the National Academy of Sciences 94 (20), 10669-10674, 1997 | 436 | 1997 |
| The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor LJ Huang, SN Constantinescu, HF Lodish Molecular cell 8 (6), 1327-1338, 2001 | 400 | 2001 |
| X-linked recessive TLR7 deficiency in~ 1% of men under 60 years old with life-threatening COVID-19 T Asano, B Boisson, F Onodi, D Matuozzo, M Moncada-Velez, ... Science immunology 6 (62), eabl4348, 2021 | 391 | 2021 |
| Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants I Chachoua, C Pecquet, M El-Khoury, H Nivarthi, RI Albu, C Marty, ... Blood, The Journal of the American Society of Hematology 127 (10), 1325-1335, 2016 | 383 | 2016 |
| Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo PS Woll, U Kjällquist, O Chowdhury, H Doolittle, DC Wedge, S Thongjuea, ... Cancer cell 25 (6), 794-808, 2014 | 379 | 2014 |
| Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain SN Constantinescu, T Keren, M Socolovsky, H Nam, YI Henis, HF Lodish Proceedings of the National Academy of Sciences 98 (8), 4379-4384, 2001 | 342 | 2001 |
| Whole-exome sequencing identifies novel MPL and JAK2 mutations in triple-negative myeloproliferative neoplasms JD Milosevic Feenstra, H Nivarthi, H Gisslinger, E Leroy, E Rumi, ... Blood, The Journal of the American Society of Hematology 127 (3), 325-332, 2016 | 333 | 2016 |
| Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis C Marty, C Pecquet, H Nivarthi, M El-Khoury, I Chachoua, M Tulliez, ... Blood, The Journal of the American Society of Hematology 127 (10), 1317-1324, 2016 | 310 | 2016 |
| JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies W Vainchenker, A Dusa, SN Constantinescu Seminars in cell & developmental biology 19 (4), 385-393, 2008 | 296 | 2008 |
| The erythropoietin receptor: structure, activation and intracellular signal transduction SN Constantinescu, S Ghaffari, HF Lodish Trends in Endocrinology & Metabolism 10 (1), 18-23, 1999 | 296 | 1999 |
| JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor J Staerk, A Kallin, JB Demoulin, W Vainchenker, SN Constantinescu Journal of Biological Chemistry 280 (51), 41893-41899, 2005 | 265 | 2005 |
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