| Fitting models to biological data using linear and nonlinear regression: a practical guide to curve fitting AC Harvey Motulsky Oxford University Press, 2004 | 3495 | 2004 |
| Strategies to address low drug solubility in discovery and development HD Williams, NL Trevaskis, SA Charman, RM Shanker, WN Charman, ... Pharmacological reviews 65 (1), 315-499, 2013 | 1793 | 2013 |
| Functional selectivity and classical concepts of quantitative pharmacology JD Urban, WP Clarke, M Von Zastrow, DE Nichols, B Kobilka, H Weinstein, ... The Journal of pharmacology and experimental therapeutics 320 (1), 1-13, 2007 | 1343 | 2007 |
| The Concise Guide to PHARMACOLOGY 2021/22: G protein‐coupled receptors SPH Alexander, A Christopoulos, AP Davenport, E Kelly, A Mathie, ... British journal of pharmacology 178, S27-S156, 2021 | 1313 | 2021 |
| Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders P Jeffrey Conn, A Christopoulos, CW Lindsley Nature reviews Drug discovery 8 (1), 41-54, 2009 | 1233 | 2009 |
| G protein-coupled receptor allosterism and complexing A Christopoulos, T Kenakin Pharmacological reviews 54 (2), 323-374, 2002 | 1034 | 2002 |
| Activation and allosteric modulation of a muscarinic acetylcholine receptor AC Kruse, AM Ring, A Manglik, J Hu, K Hu, K Eitel, H Hübner, E Pardon, ... Nature 504 (7478), 101-106, 2013 | 1002 | 2013 |
| International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology RR Neubig, M Spedding, T Kenakin, A Christopoulos Pharmacological reviews 55 (4), 597-606, 2003 | 850 | 2003 |
| Signalling bias in new drug discovery: detection, quantification and therapeutic impact T Kenakin, A Christopoulos Nature reviews Drug discovery 12 (3), 205-216, 2013 | 843 | 2013 |
| Allosteric binding sites on cell-surface receptors: novel targets for drug discovery A Christopoulos Nature reviews Drug discovery 1 (3), 198-210, 2002 | 841 | 2002 |
| Allosteric modulation of G protein–coupled receptors LT May, K Leach, PM Sexton, A Christopoulos Annu. Rev. Pharmacol. Toxicol. 47 (1), 1-51, 2007 | 830 | 2007 |
| The Concise Guide to PHARMACOLOGY 2017/18: G protein‐coupled receptors SPH Alexander, A Christopoulos, AP Davenport, E Kelly, NV Marrion, ... British journal of pharmacology 174, S17-S129, 2017 | 719 | 2017 |
| Mechanisms of signalling and biased agonism in G protein-coupled receptors D Wootten, A Christopoulos, M Marti-Solano, MM Babu, PM Sexton Nature reviews Molecular cell biology 19 (10), 638-653, 2018 | 703 | 2018 |
| G-protein–coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor E Kostenis, G Milligan, A Christopoulos, CF Sanchez-Ferrer, ... Circulation 111 (14), 1806-1813, 2005 | 551 | 2005 |
| Emerging paradigms in GPCR allostery: implications for drug discovery D Wootten, A Christopoulos, PM Sexton Nature reviews Drug discovery 12 (8), 630-644, 2013 | 542 | 2013 |
| A simple method for quantifying functional selectivity and agonist bias T Kenakin, C Watson, V Muniz-Medina, A Christopoulos, S Novick ACS chemical neuroscience 3 (3), 193-203, 2012 | 517 | 2012 |
| Phase-plate cryo-EM structure of a class B GPCR–G-protein complex YL Liang, M Khoshouei, M Radjainia, Y Zhang, A Glukhova, J Tarrasch, ... Nature 546 (7656), 118-123, 2017 | 511 | 2017 |
| Allosteric modulation of the cannabinoid CB1 receptor MR Price, GL Baillie, A Thomas, LA Stevenson, M Easson, R Goodwin, ... Molecular pharmacology 68 (5), 1484-1495, 2005 | 511 | 2005 |
| Muscarinic acetylcholine receptors: novel opportunities for drug development AC Kruse, BK Kobilka, D Gautam, PM Sexton, A Christopoulos, J Wess Nature reviews Drug discovery 13 (7), 549-560, 2014 | 482 | 2014 |
| Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs RO Dror, HF Green, C Valant, DW Borhani, JR Valcourt, AC Pan, ... Nature 503 (7475), 295-299, 2013 | 462 | 2013 |