The cytoprotective role of the Keap1–Nrf2 pathway L Baird, AT Dinkova-Kostova Archives of toxicology 85, 241-272, 2011 | 1144 | 2011 |
Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration KM Holmström, L Baird, Y Zhang, I Hargreaves, A Chalasani, JM Land, ... Biology open 2 (8), 761-770, 2013 | 467 | 2013 |
Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex L Baird, D Llères, S Swift, AT Dinkova-Kostova Proceedings of the National Academy of Sciences 110 (38), 15259-15264, 2013 | 408 | 2013 |
Characterizations of three major cysteine sensors of Keap1 in stress response R Saito, T Suzuki, K Hiramoto, S Asami, E Naganuma, H Suda, T Iso, ... Molecular and cellular biology, 2016 | 258 | 2016 |
Molecular mechanism of cellular oxidative stress sensing by Keap1 T Suzuki, A Muramatsu, R Saito, T Iso, T Shibata, K Kuwata, S Kawaguchi, ... Cell reports 28 (3), 746-758. e4, 2019 | 220 | 2019 |
Monitoring Keap1–Nrf2 interactions in single live cells L Baird, S Swift, D Llères, AT Dinkova-Kostova Biotechnology advances 32 (6), 1133-1144, 2014 | 181 | 2014 |
Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1–Nrf2 protein–protein interaction HC Bertrand, M Schaap, L Baird, ND Georgakopoulos, A Fowkes, ... Journal of medicinal chemistry 58 (18), 7186-7194, 2015 | 127 | 2015 |
Absolute amounts and status of the Nrf2-Keap1-Cul3 complex within cells T Iso, T Suzuki, L Baird, M Yamamoto Molecular and Cellular Biology 36 (24), 3100-3112, 2016 | 113 | 2016 |
NRF2 intensifies host defense systems to prevent lung carcinogenesis, but after tumor initiation accelerates malignant cell growth H Satoh, T Moriguchi, D Saigusa, L Baird, L Yu, H Rokutan, K Igarashi, ... Cancer research 76 (10), 3088-3096, 2016 | 97 | 2016 |
Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes T Tsujita, V Peirce, L Baird, Y Matsuyama, M Takaku, SV Walsh, JL Griffin, ... Molecular and cellular biology, 2014 | 95 | 2014 |
The spatiotemporal regulation of the Keap1–Nrf2 pathway and its importance in cellular bioenergetics AT Dinkova-Kostova, L Baird, KM Holmström, CJ Meyer, AY Abramov Biochemical society transactions 43 (4), 602-610, 2015 | 83 | 2015 |
Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus T Suzuki, S Seki, K Hiramoto, E Naganuma, EH Kobayashi, A Yamaoka, ... Nature communications 8 (1), 14577, 2017 | 82 | 2017 |
Diffusion dynamics of the Keap1–Cullin3 interaction in single live cells L Baird, AT Dinkova-Kostova Biochemical and biophysical research communications 433 (1), 58-65, 2013 | 62 | 2013 |
A homeostatic shift facilitates endoplasmic reticulum proteostasis through transcriptional integration of proteostatic stress response pathways L Baird, T Tsujita, EH Kobayashi, R Funayama, T Nagashima, ... Molecular and Cellular Biology 37 (4), e00439-16, 2017 | 48 | 2017 |
Geldanamycin-derived HSP90 inhibitors are synthetic lethal with NRF2 L Baird, T Suzuki, Y Takahashi, E Hishinuma, D Saigusa, M Yamamoto Molecular and Cellular Biology, 2020 | 33 | 2020 |
NRF2-dependent bioactivation of mitomycin C as a novel strategy to target KEAP1-NRF2 pathway activation in human cancer L Baird, M Yamamoto Molecular and cellular biology 41 (2), e00473-20, 2021 | 31 | 2021 |
A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells L Baird, K Taguchi, A Zhang, Y Takahashi, T Suzuki, TW Kensler, ... Redox Biology 66, 102845, 2023 | 13 | 2023 |
Novel NRF2‐activated cancer treatments utilizing synthetic lethality L Baird, TW Kensler, M Yamamoto IUBMB life 74 (12), 1209-1231, 2022 | 12 | 2022 |
The Keap1-Nrf2 pathway: From mechanism to medical applications L Baird, M Yamamoto Oxidative Stress, 125-147, 2020 | 10 | 2020 |
Discovery of an NRF 1‐specific inducer from a large‐scale chemical library using a direct NRF 1‐protein monitoring system T Tsujita, L Baird, Y Furusawa, F Katsuoka, Y Hou, S Gotoh, S Kawaguchi, ... Genes to Cells 20 (7), 563-577, 2015 | 10 | 2015 |