| Restoring function in exhausted CD8 T cells during chronic viral infection DL Barber, EJ Wherry, D Masopust, B Zhu, JP Allison, AH Sharpe, ... Nature 439 (7077), 682-687, 2006 | 5030 | 2006 |
| The future of immune checkpoint therapy P Sharma, JP Allison Science 348 (6230), 56-61, 2015 | 4822 | 2015 |
| Enhancement of antitumor immunity by CTLA-4 blockade DR Leach, MF Krummel, JP Allison Science 271 (5256), 1734-1736, 1996 | 4785 | 1996 |
| Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients V Gopalakrishnan, CN Spencer, L Nezi, A Reuben, MC Andrews, ... Science 359 (6371), 97-103, 2018 | 4231 | 2018 |
| CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. MF Krummel, JP Allison The Journal of experimental medicine 182 (2), 459-465, 1995 | 2843 | 1995 |
| Fundamental mechanisms of immune checkpoint blockade therapy SC Wei, CR Duffy, JP Allison Cancer discovery 8 (9), 1069-1086, 2018 | 2808 | 2018 |
| Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival BC Özdemir, T Pentcheva-Hoang, JL Carstens, X Zheng, CC Wu, ... Cancer cell 25 (6), 719-734, 2014 | 2622 | 2014 |
| Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential P Sharma, JP Allison Cell 161 (2), 205-214, 2015 | 2421 | 2015 |
| Immunologic correlates of the abscopal effect in a patient with melanoma MA Postow, MK Callahan, CA Barker, Y Yamada, J Yuan, S Kitano, Z Mu, ... New England Journal of Medicine 366 (10), 925-931, 2012 | 2220 | 2012 |
| CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones FA Harding, JG McArthur, JA Gross, DH Raulet, JP Allison Nature 356 (6370), 607-609, 1992 | 2220 | 1992 |
| Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens MM Gubin, X Zhang, H Schuster, E Caron, JP Ward, T Noguchi, Y Ivanova, ... Nature 515 (7528), 577-581, 2014 | 2196 | 2014 |
| PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors MA Curran, W Montalvo, H Yagita, JP Allison Proceedings of the National Academy of Sciences 107 (9), 4275-4280, 2010 | 2162 | 2010 |
| Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma GQ Phan, JC Yang, RM Sherry, P Hwu, SL Topalian, ... Proceedings of the National Academy of Sciences 100 (14), 8372-8377, 2003 | 1958 | 2003 |
| B cells and tertiary lymphoid structures promote immunotherapy response BA Helmink, SM Reddy, J Gao, S Zhang, R Basar, R Thakur, K Yizhak, ... Nature 577 (7791), 549-555, 2020 | 1953 | 2020 |
| Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma TR Simpson, F Li, W Montalvo-Ortiz, MA Sepulveda, K Bergerhoff, F Arce, ... Journal of Experimental Medicine 210 (9), 1695-1710, 2013 | 1656 | 2013 |
| The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research MA Cheever, JP Allison, AS Ferris, OJ Finn, BM Hastings, TT Hecht, ... Clinical cancer research 15 (17), 5323-5337, 2009 | 1652 | 2009 |
| Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells SE Townsend, JP Allison Science 259 (5093), 368-370, 1993 | 1627 | 1993 |
| Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting H Matsushita, MD Vesely, DC Koboldt, CG Rickert, R Uppaluri, VJ Magrini, ... Nature 482 (7385), 400-404, 2012 | 1460 | 2012 |
| Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative … RPM Sutmuller, LM van Duivenvoorde, A van Elsas, TNM Schumacher, ... The Journal of experimental medicine 194 (6), 823-832, 2001 | 1316 | 2001 |
| Combination immunotherapy of B16 melanoma using anti–cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF … A Van Elsas, AA Hurwitz, JP Allison The Journal of experimental medicine 190 (3), 355-366, 1999 | 1299 | 1999 |
