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Brandon A. Vara, Ph.D.
Brandon A. Vara, Ph.D.
University of Pennsylvania, Merck & Co (MRL)
Geverifieerd e-mailadres voor merck.com
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1, 4-Dihydropyridines as alkyl radical precursors: introducing the aldehyde feedstock to nickel/photoredox dual catalysis
A Gutiérrez-Bonet, JC Tellis, JK Matsui, BA Vara, GA Molander
ACS catalysis 6 (12), 8004-8008, 2016
2462016
Scalable thioarylation of unprotected peptides and biomolecules under Ni/photoredox catalysis
BA Vara, X Li, S Berritt, CR Walters, EJ Petersson, GA Molander
Chemical Science 9 (2), 336-344, 2018
1572018
Enantioselective small molecule synthesis by carbon dioxide fixation using a dual Brønsted acid/base organocatalyst
BA Vara, TJ Struble, W Wang, MC Dobish, JN Johnston
Journal of the American Chemical Society 137 (23), 7302-7305, 2015
1272015
O-Benzyl Xanthate Esters under Ni/Photoredox Dual Catalysis: Selective Radical Generation and Csp3–Csp2 Cross-Coupling
BA Vara, NR Patel, GA Molander
ACS catalysis 7 (6), 3955-3959, 2017
892017
C (sp 3)–C (sp 2) cross-coupling of alkylsilicates with borylated aryl bromides–an iterative platform to alkylated aryl-and heteroaryl boronates
BA Vara, M Jouffroy, GA Molander
Chemical Science 8 (1), 530-535, 2017
492017
Organocatalytic, diastereo-and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for …
BA Vara, A Mayasundari, JC Tellis, MW Danneman, V Arredondo, ...
The Journal of Organic Chemistry 79 (15), 6913-6938, 2014
492014
Enantioselective synthesis of β-fluoro amines via β-amino α-fluoro nitroalkanes and a traceless activating group strategy
BA Vara, JN Johnston
Journal of the American Chemical Society 138 (42), 13794-13797, 2016
452016
Discovery of diaminopyrimidine carboxamide HPK1 inhibitors as preclinical immunotherapy tool compounds
BA Vara, SM Levi, A Achab, DA Candito, X Fradera, CA Lesburg, ...
ACS Medicinal Chemistry Letters 12 (4), 653-661, 2021
362021
Reductive sp3–sp2 Coupling Reactions Enable Late-Stage Modification of Pharmaceuticals
KM Mennie, BA Vara, SM Levi
Organic letters 22 (2), 556-559, 2020
192020
Adaptation of a small-molecule hydrogen-bond donor catalyst to an enantioselective hetero-Diels–Alder reaction hypothesized for brevianamide biosynthesis
DJ Sprague, BM Nugent, RA Yoder, BA Vara, JN Johnston
Organic letters 17 (4), 880-883, 2015
162015
MDM2 antagonists counteract drug-induced DNA damage
AE Vilgelm, P Cobb, K Malikayil, D Flaherty, CA Johnson, D Raman, ...
EBioMedicine 24, 43-55, 2017
132017
Catal. 2016, 6, 8004–8008; d) K. Nakajima, S. Nojima, Y. Nishibayashi
JC GutiØrrez-Bonet, JK Tellis, BA Matsui, GA Vara, ACS Molander
Angew. Chem. Int. Ed 55, 14106-14110, 2016
122016
The n-dig-Cyclization (n= 5, 6) of Alkynes Involving Fixation of CO2
B Wang, S Sun, J Cheng
Synlett 29 (14), 1814-1822, 2018
62018
Activation of hepatocyte growth factor/MET signaling as a mechanism of acquired resistance to a novel YAP1/TEAD small molecule inhibitor
CJ Moure, B Vara, MM Cheng, C Sondey, E Muise, E Park, ...
Molecular Cancer Therapeutics 23 (8), 1095-1108, 2024
12024
Diaminopyrimidine carboxamide inhibitors of hpk1
A Achab, DA Candito, A Donofrio, X Fradera, S Kawamura, SM Levi, B Li, ...
US Patent App. 18/251,259, 2023
12023
Assessment of a receptor-interacting serine/threonine-protein kinase 1 (RIPK1) PET tracer feasibility:[18F] A in in vitro brain tissue based binding assay and in vivo PET …
W Li, B Vara, D Rubins, P Dockery, K Riffel, Y Wang, Z Zeng, C Sondey, ...
Journal of Nuclear Medicine 65 (supplement 2), 242075-242075, 2024
2024
Aryl ether compounds as tead modulators
J Lim, V Simov, BA Vara, CS Yeung, SE Schneider, EF DiMauro
US Patent App. 18/264,468, 2024
2024
Ripk1 inhibitors and methods of use
JL Chen, YH Chen, EF DiMauro, M Liu, JL Methot, AJ Musacchio, ...
US Patent App. 18/318,760, 2024
2024
7-phenyl substituted 2-aminoquinazoline inhibitors of hpk1
DA Candito, JL Chen, A Donofrio, X Fradera, PH Fuller, S Kawamura, B Li, ...
US Patent App. 18/250,419, 2023
2023
Spirotricycle ripk1 inhibitors and methods of uses thereof
AA Achab, ZG Brill, JLR Duque, X Fradera, JL Methot, P Siliphaivanh, ...
US Patent App. 18/049,344, 2023
2023
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