| β-Secretase as a therapeutic target for Alzheimer’s disease AK Ghosh, S Gemma, J Tang Neurotherapeutics 5, 399-408, 2008 | 271 | 2008 |
| Synthesis of N1-arylidene-N2-quinolyl-and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains S Gemma, G Kukreja, C Fattorusso, M Persico, MP Romano, M Altarelli, ... Bioorganic & medicinal chemistry letters 16 (20), 5384-5388, 2006 | 253 | 2006 |
| Multitarget compounds bearing tacrine-and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease L Ismaili, B Refouvelet, M Benchekroun, S Brogi, M Brindisi, S Gemma, ... Progress in neurobiology 151, 4-34, 2017 | 190 | 2017 |
| Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure−Activity Relationships, and Biological Studies G Campiani, E Morelli, S Gemma, V Nacci, S Butini, M Hamon, ... Journal of medicinal chemistry 42 (21), 4362-4379, 1999 | 141 | 1999 |
| Synthesis and Pharmacological Evaluation of Potent and Highly Selective D3 Receptor Ligands: Inhibition of Cocaine-Seeking Behavior and the Role of Dopamine D3/D … G Campiani, S Butini, F Trotta, C Fattorusso, B Catalanotti, F Aiello, ... Journal of medicinal chemistry 46 (18), 3822-3839, 2003 | 115 | 2003 |
| Discovery of a New Class of Potential Multifunctional Atypical Antipsychotic Agents Targeting Dopamine D3 and Serotonin 5-HT1A and 5-HT2A Receptors … S Butini, S Gemma, G Campiani, S Franceschini, F Trotta, M Borriello, ... Journal of medicinal chemistry 52 (1), 151-169, 2009 | 103 | 2009 |
| Old but gold: tracking the new guise of histone deacetylase 6 (HDAC6) enzyme as a biomarker and therapeutic target in rare diseases M Brindisi, AP Saraswati, S Brogi, S Gemma, S Butini, G Campiani Journal of medicinal chemistry 63 (1), 23-39, 2019 | 102 | 2019 |
| Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases S Maramai, S Gemma, S Brogi, G Campiani, S Butini, H Stark, M Brindisi Frontiers in neuroscience 10, 451, 2016 | 101 | 2016 |
| Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663 G Maga, S Gemma, C Fattorusso, GA Locatelli, S Butini, M Persico, ... Biochemistry 44 (28), 9637-9644, 2005 | 99 | 2005 |
| Design, synthesis, and structure–activity relationship studies of 4-quinolinyl-and 9-acrydinylhydrazones as potent antimalarial agents C Fattorusso, G Campiani, G Kukreja, M Persico, S Butini, MP Romano, ... Journal of medicinal chemistry 51 (5), 1333-1343, 2008 | 98 | 2008 |
| Modulation of the innate immune response by targeting toll-like receptors: a perspective on their agonists and antagonists S Federico, L Pozzetti, A Papa, G Carullo, S Gemma, S Butini, ... Journal of Medicinal Chemistry 63 (22), 13466-13513, 2020 | 92 | 2020 |
| Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of … G Campiani, C Fattorusso, S Butini, A Gaeta, M Agnusdei, S Gemma, ... Journal of medicinal chemistry 48 (6), 1919-1929, 2005 | 90 | 2005 |
| Development and pharmacological characterization of selective blockers of 2-arachidonoyl glycerol degradation with efficacy in rodent models of multiple sclerosis and pain M Brindisi, S Maramai, S Gemma, S Brogi, A Grillo, L Di Cesare Mannelli, ... Journal of medicinal chemistry 59 (6), 2612-2632, 2016 | 83 | 2016 |
| Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure–activity relationship studies S Gemma, L Savini, M Altarelli, P Tripaldi, L Chiasserini, SS Coccone, ... Bioorganic & Medicinal Chemistry 17 (16), 6063-6072, 2009 | 82 | 2009 |
| Polypharmacology of dopamine receptor ligands S Butini, K Nikolic, S Kassel, H Brückmann, S Filipic, D Agbaba, S Gemma, ... Progress in neurobiology 142, 68-103, 2016 | 80 | 2016 |
| Pyrrolo [1, 3] benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure− activity relationship studies, and identification of … G Campiani, S Butini, C Fattorusso, B Catalanotti, S Gemma, V Nacci, ... Journal of medicinal chemistry 47 (1), 143-157, 2004 | 79 | 2004 |
| Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking M Brindisi, S Brogi, N Relitti, A Vallone, S Butini, S Gemma, E Novellino, ... Scientific reports 5 (1), 9705, 2015 | 76 | 2015 |
| Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas T Khan, N Relitti, M Brindisi, S Magnano, D Zisterer, S Gemma, S Butini, ... Medicinal Research Reviews 40 (3), 1002-1060, 2020 | 75 | 2020 |
| Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents S Gemma, C Camodeca, M Brindisi, S Brogi, G Kukreja, S Kunjir, ... Journal of medicinal chemistry 55 (23), 10387-10404, 2012 | 72 | 2012 |
| Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors S Butini, G Campiani, M Borriello, S Gemma, A Panico, M Persico, ... Journal of medicinal chemistry 51 (11), 3154-3170, 2008 | 69 | 2008 |
