Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion C Bonner, J Kerr-Conte, V Gmyr, G Queniat, E Moerman, J Thévenet, ... Nature medicine 21 (5), 512-517, 2015 | 741 | 2015 |
The bile acid chenodeoxycholic acid increases human brown adipose tissue activity EPM Broeders, EBM Nascimento, B Havekes, B Brans, KHM Roumans, ... Cell metabolism 22 (3), 418-426, 2015 | 440 | 2015 |
Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a … D Montaigne, X Marechal, T Modine, A Coisne, S Mouton, G Fayad, ... The Lancet 391 (10115), 59-69, 2018 | 325 | 2018 |
Tuberculosis: the drug development pipeline at a glance B Villemagne, C Crauste, M Flipo, AR Baulard, B Déprez, N Willand European journal of medicinal chemistry 51, 1-16, 2012 | 263 | 2012 |
Synthetic EthR inhibitors boost antituberculous activity of ethionamide N Willand, B Dirié, X Carette, P Bifani, A Singhal, M Desroses, F Leroux, ... Nature medicine 15 (5), 537-544, 2009 | 215 | 2009 |
Parallel synthesis of 1, 2, 4-oxadiazoles from carboxylic acids using an improved, uronium-based, activation RF Poulain, AL Tartar, BP Déprez Tetrahedron Letters 42 (8), 1495-1498, 2001 | 178 | 2001 |
Rescue of nonsense mutations by amlexanox in human cells S Gonzalez-Hilarion, T Beghyn, J Jia, N Debreuck, G Berte, K Mamchaoui, ... Orphanet journal of rare diseases 7, 1-14, 2012 | 173 | 2012 |
Efficient propylphosphonic anhydride (® T3P) mediated synthesis of benzothiazoles, benzoxazoles and benzimidazoles X Wen, J El Bakali, R Deprez-Poulain, B Deprez Tetrahedron Letters 53 (19), 2440-2443, 2012 | 164 | 2012 |
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 N Blondiaux, M Moune, M Desroses, R Frita, M Flipo, V Mathys, ... Science 355 (6330), 1206-1211, 2017 | 153 | 2017 |
Versatile Acylation of N-Nucleophiles Using a New Polymer-Supported 1-Hydroxybenzotriazole Derivative IE Pop, BP Déprez, AL Tartar The Journal of Organic Chemistry 62 (8), 2594-2603, 1997 | 146 | 1997 |
Designing focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methods C Reynès, H Host, AC Camproux, G Laconde, F Leroux, A Mazars, ... PLoS computational biology 6 (3), e1000695, 2010 | 145 | 2010 |
Immunization of mice with lipopeptides bypasses the prerequisite for adjuvant. Immune response of BALB/c mice to human immunodeficiency virus envelope glycoprotein. F Martinon, H Gras-Masse, C Boutillon, F Chirat, B Deprez, JG Guillet, ... Journal of immunology (Baltimore, Md.: 1950) 149 (10), 3416-3422, 1992 | 138 | 1992 |
Hypothalamic bile acid-TGR5 signaling protects from obesity A Castellanos-Jankiewicz, O Guzmán-Quevedo, VS Fenelon, P Zizzari, ... Cell metabolism 33 (7), 1483-1492. e10, 2021 | 133 | 2021 |
Hydroxamates: relationships between structure and plasma stability M Flipo, J Charton, A Hocine, S Dassonneville, B Deprez, ... Journal of medicinal chemistry 52 (21), 6790-6802, 2009 | 126 | 2009 |
Orthogonal combinatorial chemical libraries B Deprez, X Williard, L Bourel, H Coste, F Hyafil, A Tartar Journal of the American Chemical Society 117 (19), 5405-5406, 1995 | 121 | 1995 |
Natural compounds: leads or ideas? Bioinspired molecules for drug discovery T Beghyn, R Deprez‐Poulain, N Willand, B Folleas, B Deprez Chemical biology & drug design 72 (1), 3-15, 2008 | 120 | 2008 |
Ethionamide boosters: synthesis, biological activity, and structure− activity relationships of a series of 1, 2, 4-oxadiazole EthR inhibitors M Flipo, M Desroses, N Lecat-Guillet, B Dirié, X Carette, F Leroux, ... Journal of Medicinal Chemistry 54 (8), 2994-3010, 2011 | 113 | 2011 |
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles J Costa-Gouveia, E Pancani, S Jouny, A Machelart, V Delorme, ... Scientific reports 7 (1), 5390, 2017 | 105 | 2017 |
Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice R Deprez-Poulain, N Hennuyer, D Bosc, WG Liang, E Enée, X Marechal, ... Nature communications 6 (1), 8250, 2015 | 105 | 2015 |
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1, 2, 4-oxadiazole EthR inhibitors M Flipo, M Desroses, N Lecat-Guillet, B Villemagne, N Blondiaux, ... Journal of medicinal chemistry 55 (1), 68-83, 2012 | 94 | 2012 |