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Anna Pensalfini
Anna Pensalfini
Flagship Labs
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
D Klionsky
Autophagy 12 (1), 1-222., 2016
13971*2016
A causative link between the structure of aberrant protein oligomers and their toxicity
S Campioni, B Mannini, M Zampagni, A Pensalfini, C Parrini, ...
Nature chemical biology 6 (2), 140-147, 2010
6352010
Atomic view of a toxic amyloid small oligomer
A Laganowsky, C Liu, MR Sawaya, JP Whitelegge, J Park, M Zhao, ...
Science 335 (6073), 1228-1231, 2012
6152012
Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction
JL Tomic, A Pensalfini, E Head, CG Glabe
Neurobiology of disease 35 (3), 352-358, 2009
4342009
Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer
R Kayed, A Pensalfini, L Margol, Y Sokolov, F Sarsoza, E Head, J Hall, ...
Journal of Biological Chemistry 284 (7), 4230-4237, 2009
4162009
Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques
JH Lee, DS Yang, CN Goulbourne, E Im, P Stavrides, A Pensalfini, ...
Nature neuroscience 25 (6), 688-701, 2022
3912022
Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia
IA Buhimschi, UA Nayeri, G Zhao, LL Shook, A Pensalfini, EF Funai, ...
Science translational medicine 6 (245), 245ra92-245ra92, 2014
2412014
Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease
S Kim, Y Sato, PS Mohan, C Peterhoff, A Pensalfini, A Rigoglioso, Y Jiang, ...
Molecular psychiatry 21 (5), 707-716, 2016
2212016
Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates
C Liu, M Zhao, L Jiang, PN Cheng, J Park, MR Sawaya, A Pensalfini, ...
Proceedings of the National Academy of Sciences 109 (51), 20913-20918, 2012
2112012
Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers
R Kayed, I Canto, L Breydo, S Rasool, T Lukacsovich, J Wu, R Albay, ...
Molecular neurodegeneration 5, 1-10, 2010
1872010
Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease
DJ Colacurcio, A Pensalfini, Y Jiang, RA Nixon
Free Radical Biology and Medicine 114, 40-51, 2018
1802018
Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques
A Pensalfini, R Albay III, S Rasool, JW Wu, A Hatami, H Arai, L Margol, ...
Neurobiology of disease 71, 53-61, 2014
1312014
Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-κB, and JNK pathways
C Fiorillo, M Becatti, A Pensalfini, C Cecchi, L Lanzilao, G Donzelli, ...
Free Radical Biology and Medicine 45 (6), 839-846, 2008
1092008
Insights into the molecular basis of the differing susceptibility of varying cell types to the toxicity of amyloid aggregates
C Cecchi, S Baglioni, C Fiorillo, A Pensalfini, G Liguri, D Nosi, S Rigacci, ...
Journal of cell science 118 (15), 3459-3470, 2005
1082005
New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc
C Corona, A Pensalfini, V Frazzini, SL Sensi
Cell death & disease 2 (6), e176-e176, 2011
1032011
Seladin‐1/DHCR24 protects neuroblastoma cells against Aβ toxicity by increasing membrane cholesterol content
C Cecchi, F Rosati, A Pensalfini, L Formigli, D Nosi, G Liguri, F Dichiara, ...
Journal of cellular and molecular medicine 12 (5b), 1990-2002, 2008
962008
Endosomal dysfunction induced by directly overactivating Rab5 recapitulates prodromal and neurodegenerative features of Alzheimer’s disease
A Pensalfini, S Kim, S Subbanna, C Bleiwas, CN Goulbourne, ...
Cell reports 33 (8), 2020
872020
A protective role for lipid raft cholesterol against amyloid-induced membrane damage in human neuroblastoma cells
C Cecchi, D Nichino, M Zampagni, C Bernacchioni, E Evangelisti, ...
Biochimica et Biophysica Acta (BBA)-Biomembranes 1788 (10), 2204-2216, 2009
852009
Increased susceptibility to amyloid toxicity in familial Alzheimer's fibroblasts
C Cecchi, C Fiorillo, S Baglioni, A Pensalfini, S Bagnoli, B Nacmias, ...
Neurobiology of Aging 28 (6), 863-876, 2007
712007
Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo
JH Lee, MV Rao, DS Yang, P Stavrides, E Im, A Pensalfini, C Huo, ...
Autophagy 15 (3), 543-557, 2019
632019
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학술자료 1–20