| Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment CD Funk, LB Funk, ME Kennedy, AS Pong, GA Fitzgerald The FASEB journal 5 (9), 2304-2312, 1991 | 826 | 1991 |
| The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients ME Kennedy, AW Stamford, X Chen, K Cox, JN Cumming, MF Dockendorf, ... Science translational medicine 8 (363), 363ra150-363ra150, 2016 | 469 | 2016 |
| Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects R Vassar, PH Kuhn, C Haass, ME Kennedy, L Rajendran, PC Wong, ... Journal of neurochemistry 130 (1), 4-28, 2014 | 420 | 2014 |
| Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease S Dujardin, C Commins, A Lathuiliere, P Beerepoot, AR Fernandes, ... Nature medicine 26 (8), 1256-1263, 2020 | 365 | 2020 |
| MLi-2, a potent, selective, and centrally active compound for exploring the therapeutic potential and safety of LRRK2 kinase inhibition MJ Fell, C Mirescu, K Basu, B Cheewatrakoolpong, DE DeMong, JM Ellis, ... Journal of Pharmacology and Experimental Therapeutics 355 (3), 397-409, 2015 | 281 | 2015 |
| The roles of inflammation and immune mechanisms in Alzheimer's disease LJ Van Eldik, MC Carrillo, PE Cole, D Feuerbach, BD Greenberg, ... Alzheimer's & Dementia: Translational Research & Clinical Interventions 2 (2 …, 2016 | 214 | 2016 |
| Nonselective and Gβγ-insensitive weaver K+ channels B Navarro, ME Kennedy, B Velimirović, D Bhat, AS Peterson, ... Science 272 (5270), 1950-1953, 1996 | 195 | 1996 |
| Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling. ME Kennedy, LE Limbird Journal of Biological Chemistry 268 (11), 8003-8011, 1993 | 181 | 1993 |
| Discovery of cyclic acylguanidines as highly potent and selective β-site amyloid cleaving enzyme (BACE) inhibitors: Part I Inhibitor design and validation Z Zhu, ZY Sun, Y Ye, J Voigt, C Strickland, EM Smith, J Cumming, L Wang, ... Journal of medicinal chemistry 53 (3), 951-965, 2010 | 169 | 2010 |
| Discovery of the 3-imino-1, 2, 4-thiadiazinane 1, 1-dioxide derivative verubecestat (MK-8931)–a β-site amyloid precursor protein cleaving enzyme 1 inhibitor for the treatment … JD Scott, SW Li, APJ Brunskill, X Chen, K Cox, JN Cumming, M Forman, ... Journal of medicinal chemistry 59 (23), 10435-10450, 2016 | 168 | 2016 |
| Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor JN Cumming, EM Smith, L Wang, J Misiaszek, J Durkin, J Pan, U Iserloh, ... Bioorganic & medicinal chemistry letters 22 (7), 2444-2449, 2012 | 160 | 2012 |
| Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel μM leads for the development … YS Wang, C Strickland, JH Voigt, ME Kennedy, BM Beyer, MM Senior, ... Journal of medicinal chemistry 53 (3), 942-950, 2010 | 159 | 2010 |
| Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3 TM Jelacic, ME Kennedy, K Wickman, DE Clapham Journal of Biological Chemistry 275 (46), 36211-36216, 2000 | 147 | 2000 |
| Discovery of a 3-(4-pyrimidinyl) indazole (MLi-2), an orally available and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor that reduces brain kinase activity JD Scott, DE DeMong, TJ Greshock, K Basu, X Dai, J Harris, A Hruza, ... Journal of medicinal chemistry 60 (7), 2983-2992, 2017 | 129 | 2017 |
| LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits MAS Baptista, K Merchant, T Barrett, S Bhargava, DK Bryce, JM Ellis, ... Science translational medicine 12 (540), eaav0820, 2020 | 109 | 2020 |
| GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels ME Kennedy, J Nemec, S Corey, K Wickman, DE Clapham Journal of Biological Chemistry 274 (4), 2571-2582, 1999 | 108 | 1999 |
| Discovery of an orally available, brain penetrant BACE1 inhibitor that affords robust CNS Aβ reduction AW Stamford, JD Scott, SW Li, S Babu, D Tadesse, R Hunter, Y Wu, ... ACS medicinal chemistry letters 3 (11), 897-902, 2012 | 106 | 2012 |
| Gβγ binding to GIRK4 subunit is critical for G protein-gated K+ channel activation G Krapivinsky, ME Kennedy, J Nemec, I Medina, L Krapivinsky, ... Journal of Biological Chemistry 273 (27), 16946-16952, 1998 | 103 | 1998 |
| Potent pyrrolidine-and piperidine-based BACE-1 inhibitors U Iserloh, Y Wu, JN Cumming, J Pan, LY Wang, AW Stamford, ... Bioorganic & Medicinal Chemistry Letters 18 (1), 414-417, 2008 | 102 | 2008 |
| Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor U Iserloh, J Pan, AW Stamford, ME Kennedy, Q Zhang, L Zhang, ... Bioorganic & medicinal chemistry letters 18 (1), 418-422, 2008 | 89 | 2008 |
