| Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β JM Nussbaum, S Schilling, H Cynis, A Silva, E Swanson, T Wangsanut, ... Nature 485 (7400), 651-655, 2012 | 512 | 2012 |
| Dipeptidyl peptidase IV inhibitor treatment stimulates β-cell survival and islet neogenesis in streptozotocin-induced diabetic rats JA Pospisilik, J Martin, T Doty, JA Ehses, N Pamir, FC Lynn, S Piteau, ... Diabetes 52 (3), 741-750, 2003 | 487 | 2003 |
| The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism M Engel, T Hoffmann, L Wagner, M Wermann, U Heiser, R Kiefersauer, ... Proceedings of the National Academy of Sciences 100 (9), 5063-5068, 2003 | 445 | 2003 |
| Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology S Schilling, U Zeitschel, T Hoffmann, U Heiser, M Francke, A Kehlen, ... Nature medicine 14 (10), 1106-1111, 2008 | 417 | 2008 |
| Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide RA Pederson, HA White, D Schlenzig, RP Pauly, CHS McIntosh, ... Diabetes 47 (8), 1253-1258, 1998 | 397 | 1998 |
| Type 2 diabetes—therapy with dipeptidyl peptidase IV inhibitors HU Demuth, CHS McIntosh, RA Pederson Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1751 (1), 33-44, 2005 | 350 | 2005 |
| On the seeding and oligomerization of pGlu-amyloid peptides (in vitro) S Schilling, T Lauber, M Schaupp, S Manhart, E Scheel, G Böhm, ... Biochemistry 45 (41), 12393-12399, 2006 | 329 | 2006 |
| Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and β-cell … JA Pospisilik, SG Stafford, HU Demuth, R Brownsey, W Parkhouse, ... Diabetes 51 (4), 943-950, 2002 | 311 | 2002 |
| Use of dipeptidyl peptidase IV effectors for lowering the blood glucose level in mammals HU Demuth, F Rosche, J Schmidt, RP Pauly, CHS McIntosh, ... US Patent 6,303,661, 2001 | 297 | 2001 |
| Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor C Parthier, M Kleinschmidt, P Neumann, R Rudolph, S Manhart, ... Proceedings of the National Academy of Sciences 104 (35), 13942-13947, 2007 | 267 | 2007 |
| Dipeptidyl peptidase IV inhibitors: how do they work as new antidiabetic agents? CH Mcintosh, HU Demuth, JA Pospisilik, R Pederson Regulatory peptides 128 (2), 159-165, 2005 | 260 | 2005 |
| Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides D Schlenzig, S Manhart, Y Cinar, M Kleinschmidt, G Hause, D Willbold, ... Biochemistry 48 (29), 7072-7078, 2009 | 239 | 2009 |
| Glucose-dependent insulinotropic polypeptide promotes β-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen … JA Ehses, VR Casilla, TIM Doty, JA Pospisilik, KD Winter, HU Demuth, ... Endocrinology 144 (10), 4433-4445, 2003 | 228 | 2003 |
| Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model O Wirths, H Breyhan, H Cynis, S Schilling, HU Demuth, TA Bayer Acta neuropathologica 118, 487-496, 2009 | 220 | 2009 |
| Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions S Schilling, T Hoffmann, S Manhart, M Hoffmann, HU Demuth FEBS letters 563 (1-3), 191-196, 2004 | 214 | 2004 |
| Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1 SA Hinke, K Kühn-Wache, T Hoffmann, RA Pederson, CHS McIntosh, ... Biochemical and biophysical research communications 291 (5), 1302-1308, 2002 | 214 | 2002 |
| Investigation of glucose-dependent insulinotropic polypeptide (1-42) and glucagon-like peptide-1-(7-36) degradation in vitro by dipeptidyl peptidase IV using matrix-assisted … RP Pauly, F Rosche, M Wermann, CHS McIntosh, RA Pederson, ... Journal of Biological Chemistry 271 (38), 23222-23229, 1996 | 207 | 1996 |
| The role of dipeptidyl peptidase IV in human T lymphocyte activation. Inhibitors and antibodies against dipeptidyl peptidase IV suppress lymphocyte proliferation and … E Schön, S Jahn, ST Kiessig, HU Demuth, K Neubert, A Barth, ... European journal of immunology 17 (12), 1821-1826, 1987 | 200 | 1987 |
| Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study JA Pospisilik, SG Stafford, HU Demuth, CHS McIntosh, RA Pederson Diabetes 51 (9), 2677-2683, 2002 | 184 | 2002 |
| Effectors of dipeptidyl peptidase IV HU Demuth, K Glund, D Schlenzig, S Kruber US Patent 6,548,481, 2003 | 176 | 2003 |
John Andrew PospisilikVan Andel Institute確認したメール アドレス: vai.org