| Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy K Keller, M Jung Epigenetic Therapy of Cancer: Preclinical Models and Treatment Approaches …, 2013 | 472 | 2013 |
| Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy L Morera, M Lübbert, M Jung Clinical epigenetics 8, 1-16, 2016 | 442 | 2016 |
| SIRT1 regulates HIV transcription via Tat deacetylation S Pagans, A Pedal, BJ North, K Kaehlcke, BL Marshall, A Dorr, ... PLoS biology 3 (2), e41, 2005 | 436 | 2005 |
| Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals) M Schiedel, D Herp, S Hammelmann, S Swyter, A Lehotzky, D Robaa, ... Journal of medicinal chemistry 61 (2), 482-491, 2018 | 316 | 2018 |
| Selective Sirt2 inhibition by ligand-induced rearrangement of the active site T Rumpf, M Schiedel, B Karaman, C Roessler, BJ North, A Lehotzky, ... Nature communications 6 (1), 6263, 2015 | 299 | 2015 |
| HDAC8: a multifaceted target for therapeutic interventions A Chakrabarti, I Oehme, O Witt, G Oliveira, W Sippl, C Romier, RJ Pierce, ... Trends in pharmacological sciences 36 (7), 481-492, 2015 | 298 | 2015 |
| Inhibitors of histone deacetylase as new anticancer agents M Jung Current Medicinal Chemistry 8 (12), 1505-1511, 2001 | 286 | 2001 |
| Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation M Jung, G Brosch, D Kölle, H Scherf, C Gerhäuser, P Loidl Journal of Medicinal Chemistry 42 (22), 4669-4679, 1999 | 265 | 1999 |
| Structure–Activity Studies on Suramin Analogues as Inhibitors of NAD+‐Dependent Histone Deacetylases (Sirtuins) J Trapp, R Meier, D Hongwiset, MU Kassack, W Sippl, M Jung ChemMedChem: Chemistry Enabling Drug Discovery 2 (10), 1419-1431, 2007 | 244 | 2007 |
| Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni M Marek, S Kannan, AT Hauser, M Moraes Mourão, S Caby, V Cura, ... PLoS pathogens 9 (9), e1003645, 2013 | 208 | 2013 |
| The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors A Spannhoff, AT Hauser, R Heinke, W Sippl, M Jung ChemMedChem: Chemistry Enabling Drug Discovery 4 (10), 1568-1582, 2009 | 207 | 2009 |
| Structure–activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode RC Neugebauer, U Uchiechowska, R Meier, H Hruby, V Valkov, E Verdin, ... Journal of medicinal chemistry 51 (5), 1203-1213, 2008 | 206 | 2008 |
| Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition J Trapp, A Jochum, R Meier, L Saunders, B Marshall, C Kunick, E Verdin, ... Journal of medicinal chemistry 49 (25), 7307-7316, 2006 | 206 | 2006 |
| Target-based approach to inhibitors of histone arginine methyltransferases A Spannhoff, R Heinke, I Bauer, P Trojer, E Metzger, R Gust, R Schüle, ... Journal of medicinal chemistry 50 (10), 2319-2325, 2007 | 174 | 2007 |
| Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors Y Zhang, M Jung, A Dritschilo, M Jung Radiation research 161 (6), 667-674, 2004 | 174 | 2004 |
| Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates SW Remiszewski, LC Sambucetti, P Atadja, KW Bair, WD Cornell, ... Journal of medicinal chemistry 45 (4), 753-757, 2002 | 172 | 2002 |
| Subtype selective substrates for histone deacetylases B Heltweg, F Dequiedt, BL Marshall, C Brauch, M Yoshida, N Nishino, ... Journal of medicinal chemistry 47 (21), 5235-5243, 2004 | 164 | 2004 |
| Impairment of prostate cancer cell growth by a selective and reversible LSD1 inhibitor D Willmann, S Lim, S Wetzel, E Metzger, A Jandausch, W Wilk, M Jung, ... International Journal of Cancer 128, 574-586, 2012 | 157* | 2012 |
| In vitro assays for the determination of histone deacetylase activity B Heltweg, J Trapp, M Jung Methods 36 (4), 332-337, 2005 | 156 | 2005 |
| Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo JM Gajer, SD Furdas, A Gründer, M Gothwal, U Heinicke, K Keller, ... Oncogenesis 4 (2), e137-e137, 2015 | 153 | 2015 |
Wolfgang SipplProfessor of Medicinal Chemistry確認したメール アドレス: pharmazie.uni-halle.de
