オープンアクセス

オープンアクセスを義務付けられた論文 - Manfred Jung詳細

一般には非公開: 47 件

Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals)

M Schiedel, D Herp, S Hammelmann, S Swyter, A Lehotzky, D Robaa, ...

Journal of medicinal chemistry 61 (2), 482-491, 2018

委任: German Research Foundation, Hungarian Scientific Research Fund, European …

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The Current State of NAD⁺‐Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets

M Schiedel, D Robaa, T Rumpf, W Sippl, M Jung

Medicinal research reviews 38 (1), 147-200, 2018

委任: European Commission

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Synthesis and biological investigation of oxazole hydroxamates as highly selective histone deacetylase 6 (HDAC6) inhibitors

J Senger, J Melesina, M Marek, C Romier, I Oehme, O Witt, W Sippl, ...

Journal of medicinal chemistry 59 (4), 1545-1555, 2016

委任: German Research Foundation, National Institute of Health and Medical …

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Thiobarbiturates as Sirtuin Inhibitors: Virtual Screening, Free‐energy calculations, and biological testing

U Uciechowska, J Schemies, RC Neugebauer, EM Huda, ML Schmitt, ...

ChemMedChem: Chemistry Enabling Drug Discovery 3 (12), 1965-1976, 2008

委任: German Research Foundation

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The Discovery of a Highly Selective 5,6,7,8‐Tetrahydrobenzo[4,5]thieno[2,3‐d]pyrimidin‐4(3H)‐one SIRT2 Inhibitor that is Neuroprotective in an in vitro Parkinson …

P Di Fruscia, E Zacharioudakis, C Liu, S Moniot, S Laohasinnarong, ...

ChemMedChem 10 (1), 69-82, 2015

委任: German Research Foundation, UK Biotechnology and Biological Sciences …

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Histone deacetylase inhibitors that target tubulin

J Schemies, W Sippl, M Jung

Cancer letters 280 (2), 222-232, 2009

委任: German Research Foundation

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Discovery of Inhibitors of Schistosoma mansoni HDAC8 by Combining Homology Modeling, Virtual Screening, and in Vitro Validation

S Kannan, J Melesina, AT Hauser, A Chakrabarti, T Heimburg, ...

Journal of Chemical Information and Modeling 54 (10), 3005-3019, 2014

委任: National Institute of Health and Medical Research, France

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Structure‐based development of an affinity probe for Sirtuin 2

M Schiedel, T Rumpf, B Karaman, A Lehotzky, S Gerhardt, J Ovádi, ...

Angewandte Chemie International Edition 55 (6), 2252-2256, 2016

委任: German Research Foundation, Hungarian Scientific Research Fund

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HDAC6 as a target for antileukemic drugs in acute myeloid leukemia

B Hackanson, L Rimmele, M Benkißer, M Abdelkarim, M Fliegauf, M Jung, ...

Leukemia Research 36, 1055-1062, 2012

委任: German Research Foundation

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A continuous, fluorogenic sirtuin 2 deacylase assay: substrate screening and inhibitor evaluation

I Galleano, M Schiedel, M Jung, AS Madsen, CA Olsen

Journal of medicinal chemistry 59 (3), 1021-1031, 2016

委任: Danish Council for Independent Research, European Commission

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Mind the methyl: methyllysine binding proteins in epigenetic regulation

T Wagner, D Robaa, W Sippl, M Jung

ChemMedChem 9 (3), 466-483, 2014

委任: German Research Foundation

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Schiff bases derived from p-aminobenzyl alcohol as trigger groups for pH-dependent prodrug activation

IA Müller, F Kratz, M Jung, A Warnecke

Tetrahedron Letters 51 (33), 4371-4374, 2010

委任: German Research Foundation

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Virtual screening of PRK1 inhibitors: ensemble docking, rescoring using binding free energy calculation and QSAR model development

I Slynko, M Scharfe, T Rumpf, J Eib, E Metzger, R Schule, M Jung, W Sippl

Journal of chemical information and modeling 54, 138-150, 2013

委任: German Research Foundation

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Two-Step Synthesis of Novel, Bioactive Derivatives of the Ubiquitous Cofactor Nicotinamide Adenine Dinucleotide (NAD)

T Pesnot, J Kempter, J Schemies, G Pergolizzi, U Uciechowska, T Rumpf, ...

Journal of Medicinal Chemistry 54, 3492-3499, 2011

委任: German Research Foundation

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Structure-activity studies on N-substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic …

J Schulz-Fincke, M Hau, J Barth, D Robaa, D Willmann, A Kürner, J Haas, ...

European Journal of Medicinal Chemistry 144, 52-67, 2018

委任: German Research Foundation, European Commission

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Synthesis and biological activity of splitomicin analogs targeted at human NAD+-dependent histone deacetylases (sirtuins)

M Freitag, J Schemies, T Larsen, KE Gaghlab, F Schulz, T Rumpf, M Jung, ...

Bioorganic & medicinal chemistry 19, 3669-3677, 2011

委任: German Research Foundation

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Identification and structure–activity relationship studies of small‐molecule inhibitors of the methyllysine reader protein Spindlin1

D Robaa, T Wagner, C Luise, L Carlino, J McMillan, R Flaig, R Schüle, ...

ChemMedChem 11 (20), 2327-2338, 2016