フォロー
robert macleod
robert macleod
CSO ADARx Pharmaceuticals
確認したメール アドレス: adarx.com
タイトル
引用先
引用先
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non–small-cell lung cancer
M Fukuoka, S Yano, G Giaccone, T Tamura, K Nakagawa, JY Douillard, ...
Journal of clinical oncology 21 (12), 2237-2246, 2003
39812003
The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells
T Gutschner, M Hämmerle, M Eißmann, J Hsu, Y Kim, G Hung, A Revenko, ...
Cancer research 73 (3), 1180-1189, 2013
17582013
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells
MF Robert, S Morin, N Beaulieu, F Gauthier, IC Chute, A Barsalou, ...
Nature genetics 33 (1), 61-65, 2003
7932003
Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss
G Arun, S Diermeier, M Akerman, KC Chang, JE Wilkinson, S Hearn, ...
Genes & development 30 (1), 34-51, 2016
5982016
Targeting nuclear RNA for in vivo correction of myotonic dystrophy
TM Wheeler, AJ Leger, SK Pandey, AR MacLeod, M Nakamori, SH Cheng, ...
Nature 488 (7409), 111-115, 2012
5452012
AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer
D Hong, R Kurzrock, Y Kim, R Woessner, A Younes, J Nemunaitis, ...
Science translational medicine 7 (314), 314ra185-314ra185, 2015
4622015
MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo
M Fournel, C Bonfils, Y Hou, PT Yan, MC Trachy-Bourget, A Kalita, J Liu, ...
Molecular cancer therapeutics 7 (4), 759-768, 2008
3972008
Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding
AS Revenko, D Gao, JR Crosby, G Bhattacharjee, C Zhao, C May, ...
Blood, The Journal of the American Society of Hematology 118 (19), 5302-5311, 2011
2452011
Inhibition of tumorigenesis by a cytosine–DNA, methyltransferase, antisense oligodeoxynucleotide
S Ramchandani, AR MacLeod, M Pinard, E Von Hofe, M Szyf
Proceedings of the National Academy of Sciences 94 (2), 684-689, 1997
2361997
Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk
H Zhang, EC Löwenberg, JR Crosby, AR MacLeod, C Zhao, D Gao, ...
Blood, The Journal of the American Society of Hematology 116 (22), 4684-4692, 2010
2292010
Regulation of DNA methylation by the Ras signaling pathway
AR MacLeod, J Rouleau, M Szyf
Journal of Biological Chemistry 270 (19), 11327-11337, 1995
2251995
An essential role for DNA methyltransferase DNMT3B in cancer cell survival
N Beaulieu, S Morin, IC Chute, MF Robert, H Nguyen, AR MacLeod
Journal of Biological Chemistry 277 (31), 28176-28181, 2002
2182002
Release of methyl CpG binding proteins and histone deacetylase 1 from the estrogen receptor α (ER) promoter upon reactivation in ER-negative human breast cancer cells
D Sharma, J Blum, X Yang, N Beaulieu, AR Macleod, NE Davidson
Molecular endocrinology 19 (7), 1740-1751, 2005
2142005
STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial
MJ Reilley, P McCoon, C Cook, P Lyne, R Kurzrock, Y Kim, R Woessner, ...
Journal for immunotherapy of cancer 6 (1), 1-10, 2018
2102018
Expression of Antisense to DNA Methyltransferase mRNA Induces DNA Demethylation and Inhibits Tumorigenesis (∗)
AR MacLeod, M Szyf
Journal of Biological Chemistry 270 (14), 8037-8043, 1995
2011995
Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS
SJ Ross, AS Revenko, LL Hanson, R Ellston, A Staniszewska, N Whalley, ...
Science translational medicine 9 (394), 2017
1992017
Regulation of the DNA Methyltransferase by the Ras-AP-1 Signaling Pathway (∗)
J Rouleau, AR MacLeod, M Szyf
Journal of Biological Chemistry 270 (4), 1595-1601, 1995
1671995
Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates
JR Crosby, U Marzec, AS Revenko, C Zhao, D Gao, A Matafonov, ...
Arteriosclerosis, thrombosis, and vascular biology 33 (7), 1670-1678, 2013
1662013
Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation
FJ Reu, SI Bae, L Cherkassky, DW Leaman, D Lindner, N Beaulieu, ...
J Clin Oncol 24 (23), 3771-3779, 2006
1602006
Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16ink4A and p21WAF/Cip1 by distinct mechanisms
M Fournel, P Sapieha, N Beaulieu, JM Besterman, AR MacLeod
Journal of Biological Chemistry 274 (34), 24250-24256, 1999
1601999
現在システムで処理を実行できません。しばらくしてからもう一度お試しください。
論文 1–20