オープン アクセス

Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes

Y Chen, GB Craven, RA Kamber, A Cuesta, S Zhersh, YS Moroz, ...

Nature Chemistry 15 (11), 1616-1625, 2023

委任: State of Califonia

Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation

GB Craven, H Chu, JD Sun, JD Carelli, B Coyne, H Chen, Y Chen, X Ma, ...

Nature, 1-10, 2024

委任: Howard Hughes Medical Institute

一般公開: 82 件

[HTML] nature.com

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier, KM White, ...

Nature 583 (7816), 459-468, 2020

委任: US Department of Defense, US National Institutes of Health, Howard Hughes …

[HTML] science.org

Phase separation of signaling molecules promotes T cell receptor signal transduction

X Su, JA Ditlev, E Hui, W Xing, S Banjade, J Okrut, DS King, J Taunton, ...

Science 352 (6285), 595-599, 2016

委任: Swiss National Science Foundation, US National Institutes of Health, Howard …

The promise and peril of chemical probes

CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...

Nature Chemical Biology 11 (8), 536-541, 2015

委任: US National Institutes of Health, Cancer Research UK, UK Medical Research …

High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases

F Chen, SM Pruett-Miller, Y Huang, M Gjoka, K Duda, J Taunton, ...

Nature methods 8 (9), 753-755, 2011

委任: US National Institutes of Health, Howard Hughes Medical Institute

Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

IM Serafimova, MA Pufall, S Krishnan, K Duda, MS Cohen, RL Maglathlin, ...

Nature chemical biology 8 (5), 471-476, 2012

委任: US National Institutes of Health, Howard Hughes Medical Institute

Prolonged and tunable residence time using reversible covalent kinase inhibitors

JM Bradshaw, JM McFarland, VO Paavilainen, A Bisconte, D Tam, ...

Nature chemical biology 11 (7), 525-531, 2015

委任: US National Institutes of Health, Howard Hughes Medical Institute, Academy …

Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains

MA Puthenveedu, B Lauffer, P Temkin, R Vistein, P Carlton, K Thorn, ...

Cell 143 (5), 761-773, 2010

委任: US National Institutes of Health

Broad-spectrum kinase profiling in live cells with lysine-targeted sulfonyl fluoride probes

Q Zhao, X Ouyang, X Wan, KS Gajiwala, JC Kath, LH Jones, ...

Journal of the American Chemical Society 139 (2), 680-685, 2017

委任: US National Institutes of Health, Howard Hughes Medical Institute

Comparative flavivirus-host protein interaction mapping reveals mechanisms of dengue and Zika virus pathogenesis

PS Shah, N Link, GM Jang, PP Sharp, T Zhu, DL Swaney, JR Johnson, ...

Cell 175 (7), 1931-1945. e18, 2018

委任: US Department of Defense, US National Institutes of Health, Howard Hughes …

[HTML] acs.org

Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis

S Krishnan, RM Miller, B Tian, RD Mullins, MP Jacobson, J Taunton

Journal of the American Chemical Society 136 (36), 12624-12630, 2014

委任: US National Institutes of Health, Howard Hughes Medical Institute, Science …

[PDF] cell.com

Covalent docking of large libraries for the discovery of chemical probes

N London, RM Miller, JJ Irwin, O Eidam, L Gibold, R Bonnet, BK Shoichet, ...

Biophysical Journal 106 (2), 264a, 2014

委任: US National Institutes of Health, Howard Hughes Medical Institute, National …

Decoding mammalian ribosome-mRNA states by translational GTPase complexes

S Shao, J Murray, A Brown, J Taunton, V Ramakrishnan, RS Hegde

Cell 167 (5), 1229-1240. e15, 2016

委任: US National Institutes of Health, UK Medical Research Council, Wellcome Trust

[PDF] cell.com

RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells

U Doehn, C Hauge, SR Frank, CJ Jensen, K Duda, JV Nielsen, ...

Molecular cell 35 (4), 511-522, 2009

委任: US National Institutes of Health

Electrophilic fragment-based design of reversible covalent kinase inhibitors

RM Miller, VO Paavilainen, S Krishnan, IM Serafimova, J Taunton

Journal of the American Chemical Society 135 (14), 5298-5301, 2013

委任: US National Institutes of Health, Howard Hughes Medical Institute

Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor

A Bowers, N West, J Taunton, SL Schreiber, JE Bradner, RM Williams

Journal of the American Chemical Society 130 (33), 11219-11222, 2008

委任: US National Institutes of Health

βTrCP-and Rsk1/2-mediated degradation of BimEL inhibits apoptosis

E Dehan, F Bassermann, D Guardavaccaro, G Vasiliver-Shamis, ...

Molecular cell 33 (1), 109-116, 2009

委任: US National Institutes of Health, Howard Hughes Medical Institute

Target identification by diazirine photo‐cross‐linking and click chemistry

AL MacKinnon, J Taunton

Current protocols in chemical biology 1 (1), 55-73, 2009

委任: US National Institutes of Health, Howard Hughes Medical Institute

[HTML] jci.org